Maintaining an ideal body weight and stress response

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590768
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Kagoshima University
• Principal Investigator: ASAKAWA Akihiro 鹿児島大学, 医歯学総合研究科, 准教授 (10452947)
• Co-Investigator(Kenkyū-buntansha): FUJIMIY Mineko 札幌医科大学, 医学部, 教授 (10199359) ; HORIUCHI Masahisa 鹿児島大学, 医歯(薬)学総合研究科, 准教授 (50264403) ; USHIKAI Miharu 鹿児島大学, 医歯(薬)学総合研究科, 特任助教 (70232816) ; INUI Akio 鹿児島大学, 医歯(薬)学総合研究科, 教授 (80168418)
• Project Period (FY): 2009 – 2011
• Keywords: 心療内科学 / 心身相関

Research Abstract

Centrally administered urocortin 3(Ucn3) decreased gastric emptying rate and disrupted motor activity in the antrum and duodenum of conscious food-deprived mice. Chronic psychological stress disrupted the fasted motility in the antrum of conscious food-deprived rats. mRNA expression of Ucn3 in the hypothalamus was increased by chronic psychological stress. Intracerebroventricular administration of Ucn3 antiserum prevented alteration in antral motility induced by chronic psychological stress. Ucn3 and corticotrophin releasing factor-receptor 2 may be promising targets for the treatment of stress-related diseases.

Research Products

• [Journal Article] Ghrelin and anorexia nervosa : a psychosomatic perspective (2011)
  • Author(s): Ogiso K, Asakawa A, Amitani H, Inui A.
  • Journal Title: Nutrition Volume: 27 Pages: 988-93
  • Peer Reviewed
• [Journal Article] Ghrelin, des-acyl ghrelin and obestatin on the gastrointestinal motility (2011)
  • Author(s): Fujimiya M, Ataka K, Asakawa A, Chen CY, Kato I, Inui A.
  • Journal Title: Peptides Volume: 32 Pages: 2348-51
  • Peer Reviewed
• [Journal Article] Centrally administered urocortin 3 inhibits food intake and gastric emptying in mice (2011)
  • Author(s): Ushikai M, Asakawa A, Sakoguchi T, Tanaka C, Inui A.
  • Journal Title: Endocrine Volume: 39 Pages: 113-7
  • Peer Reviewed
• [Journal Article] Effect of exercise and high-fat diet on plasma adiponectin and nesfatin levels in mice (2011)
  • Author(s): Chaolu H, Asakawa A, Ushikai M, Li YX, Cheng KC, Li JB, Zoshiki T, Terashi M, Tanaka C, Atsuchi K, Sakoguchi T, Tsai M, Amitani H, Horiuchi M, Takeuchi T, Inui A.
  • Journal Title: Exp Therap Med Volume: 2 Pages: 369-73
  • Peer Reviewed
• [Journal Article] The role of ghrelin in energy homeostasis and its potential clinical relevance (2010)
  • Author(s): Cheng KC, Li YX, Asakawa A, Inui A.
  • Journal Title: Int J Mol Med Volume: 26 Pages: 771-8
  • Peer Reviewed
• [Journal Article] Centrally administered nesfatin-1 inhibits feeding behaviour and gastroduodenal motility in mice (2010)
  • Author(s): Atsuchi K, Asakawa A, Ushikai M, Ataka K, Tsai M, Koyama K, Sato Y, Kato I, Fujimiya M, Inui A.
  • Journal Title: Neuroreport Volume: 21 Pages: 1008-11
  • Peer Reviewed
• [Journal Article] Centrally administered neuromedin S inhibits feeding behavior and gastroduodenal motility in mice (2010)
  • Author(s): Atsuchi K, Asakawa A, Ushikai M, Ataka K, Tanaka R, Kato I, Fujimiya M, Inui A.
  • Journal Title: Horm Metab Res Volume: 42 Pages: 535-8
  • Peer Reviewed
• [Journal Article] Chronic foot-shock stress potentiates the influx of bone marrow-derived microglia into hippocampus (2010)
  • Author(s): Brevet M, Kojima H, Asakawa A, Atsuchi K, Ushikai M, Ataka K, Inui A, Kimura H, Sevestre H, Fujimiya M.
  • Journal Title: J Neurosci Res Volume: 88 Pages: 1890-7
  • Peer Reviewed
• [Journal Article] Selective serotonin reuptake inhibitors modify physiological gastrointestinal motor activities via 5-HT2c receptor and acyl ghrelin (2009)
  • Author(s): Fujitsuka N, Asakawa A, Hayashi M, Sameshima M, Amitani H, Kojima S, Fujimiya M, Inui A.
  • Journal Title: Biol Psychiatry Volume: 65 Pages: 748-59
  • Peer Reviewed
• [Journal Article] Comparison of the anorexigenic activity of CRF family peptides (2009)
  • Author(s): Tanaka C, Asakawa A, Ushikai M, Sakoguchi T, Amitani H, Terashi M, Cheng K, Chaolu H, Nakamura N, Inui A.
  • Journal Title: Biochem Biophys Res Commun Volume: 390 Pages: 887-91
  • Peer Reviewed
• [Journal Article] Alteration of antral and proximal colonic motility induced by chronic psychological stress involves central urocortin 3 and vasopressin in rats
  • Author(s): Ataka K, Nagaishi K, Asakawa A, Inui A, Fujimiya M.
  • Journal Title: Am J Physiol Gastrointest Liver Physiol Volume: (in press)
  • Peer Reviewed
• [Presentation] 摂食障害研究の新たな展開-末梢における摂食調節ペプチドからのアプローチー (2011)
  • Author(s): 浅川明弘、乾明夫
  • Organizer: 第52回日本心身医学会総会
  • Place of Presentation: 神奈川県
  • Year and Date: 2011-06-09
• [Presentation] Ghrelin family of peptides and gut motility (2010)
  • Author(s): Asakawa A, Ataka K, Fujimiya M, Inui A
  • Organizer: The 1st Asian pacific topic conference
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 20101126-27
• [Presentation] Gastric ghrelin signaling and autonomic nervous system activity in rats (2010)
  • Author(s): Asakawa A, Niijima A, Fujitsuka N, Hattori T, Sameshima M, Amitani H, Inui A.
  • Organizer: Digestive Disease Week
  • Place of Presentation: New Orleans, USA
  • Year and Date: 20100501-05
• [Presentation] New method of manometric measurement of gastroduodenal motility in conscious mice (2010)
  • Author(s): Fujimiya M, Tanaka R, Ataka K, Atsuchi K, Asakawa A, Inui A.
  • Organizer: Digestive Disease Week
  • Place of Presentation: New Orleans, USA
  • Year and Date: 20100501-05
• [Presentation] Acyl ghrelin improves selective serotonin reuptake inhibitor-induced gastrointestinal motility (2010)
  • Author(s): Asakawa A, Amitani H, Sameshima M, Hayashi M, Fujitsuka N, Inui A.
  • Organizer: 1st international congress of translational research in human nutrition
  • Place of Presentation: Clermont-Ferrand, France
  • Year and Date: 20100319-20
• [Presentation] The role of the 5-Ht2c receptor in tumor-induced anorexia and gastrointestinal motility (2010)
  • Author(s): Asakawa A, Amitani H, Sameshima M, Hayashi M, Fujitsuka N, Inui A.
  • Organizer: 1st international congress of translational research in human nutrition
  • Place of Presentation: Clermont-Ferrand, France
  • Year and Date: 20100319-20
• [Presentation] 新規Brain-Gutホルモンの摂食調節基盤PP (2010)
  • Author(s): 浅川明弘、乾明夫
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 群馬県
  • Year and Date: 2010-10-01
• [Presentation] A central serotonin 2C receptor pathway regulates gastrointestinal motor activity via ghrelin neuropeptide Y signaling, but does not require downstream activation of melanocortin 3/4 receptors in rats (2009)
  • Author(s): Asakawa A, Fujitsuka N, Hayashi M, Sameshima M, Amitani H, Fujimiya M, Inui A.
  • Organizer: 5^<th> Cachexia conference
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20091205-08
• [Presentation] Acyl ghrelin improves selective serotonin reuptake inhibitor-induced gastrointestinal motility in rats (2009)
  • Author(s): Ushikai M, Asakawa A, Amitani H, Sameshima M, Hayashi M, Fujitsuka N, Inui A.
  • Organizer: 5^<th> Cachexia conference
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20091205-08
• [Presentation] The role of the 5-Ht2c receptor in tumor-induced anorexia and gastrointestinal motility in rats (2009)
  • Author(s): Amitani H, Asakawa A, Sameshima M, Hayashi M, Fujitsuka N, Inui A.
  • Organizer: 5^<th> Cachexia conference
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20091205-08
• [Presentation] A central serotonin 2C receptor pathway regulates gastrointestinal motor activity via ghrelinneuropeptide Y signaling, but does not require downstream activation of melanocortin 3/4 receptors in rats (2009)
  • Author(s): Asakawa A, Fujitsuka N, Hayashi M, Sameshima M, Amitani H, Fujimiya M, Inui A.
  • Organizer: 2009 International symposium on ghrelin
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 20091118-20
• [Presentation] A central serotonin 2C receptor pathway regulates gastrointestinal motor activity via ghrelin-neuropeptide Y signaling, but does not require downstream activation of melanocortin 3/4 receptors in rats (2009)
  • Author(s): Asakawa A, Fujitsuka N, Hayashi M, Sameshima M, Amitani H, Kojima S, Fujimiya M, Inui A.
  • Organizer: Digestive Disease Week
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-05-31
• [Presentation] 脳-胃相関とグレリン (2009)
  • Author(s): 浅川明弘
  • Organizer: 第82回日本内分泌学会学術総会
  • Place of Presentation: 群馬県
  • Year and Date: 2009-04-23
• [Presentation] グレリンファミリーペプチドと消化管運動 (2009)
  • Author(s): 浅川明弘、藤宮峯子、乾明夫
  • Organizer: 第4回日本消化管学会
  • Place of Presentation: 東京都
  • Year and Date: 2009-02-12