2011 Fiscal Year Final Research Report
Study on clarification of action mechanism of a Kampo medicine, Hochuekkito through immunomodulating exosome
| Project/Area Number |
21590772
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kitasato University |
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Principal Investigator |
YAMADA Haruki 北里大学, 大学院・感染制御科学府, 教授 (60096691)
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| Co-Investigator(Renkei-kenkyūsha) |
KIYOHARA Hiroaki 北里大学, 大学院・感染制御科学府, 准教授 (70161601)
NAGAI Takayuki 北里大学, 大学院・感染制御科学府, 講師 (00172487)
YABE Takeshi 北里大学, 大学院・感染制御科学府, 講師 (40239835)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 漢方薬 / 補中益気湯 / 液膜小胞 / 粘膜免疫機構 / 腸上皮細胞 / プロテオーム解析 |
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| Research Abstract |
In this study, effect of oral administration of a Kampo medicine, Hochuekkito was analyzed on expression of immunologically-relevant protein molecules in exosome of mice. Analyses of mRNA expression suggest that oral administration of Hochuekkito up-regulates mRNA of NOD2, TLR9, IRAK-M(intestinal epithelia) and RANKL(Peyer's patches) of mice. Western blotting analysis of exosome from peripheral blood of mice assumes that NOD2 content in the exosome may increase by oral administration of the formula.
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