The clinical significance of chronic kidney disease and its biomarker in the oldest old

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590775
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Keio University
• Principal Investigator: ARAI Yasumichi 慶應義塾大学, 医学部, 助教 (20255467)
• Co-Investigator(Kenkyū-buntansha): HIROSE Nobuyoshi 慶應義塾大学, 医学部, 講師 (90142421)
• Co-Investigator(Renkei-kenkyūsha): TAKAYAMA Michiyo 慶應義塾大学, 医学部, 助教 (60265824) ; TAKAYAMA Midori 慶應義塾大学, 理工学部, 准教授 (10308025) ; IINUMA Toshimitsu 日本大学, 歯学部, 講師 (10246902)
• Project Period (FY): 2009 – 2011
• Keywords: 超高齢者 / 慢性腎臓病 / 動脈硬化 / シスタチンC

Research Abstract

To examine the clinical implication of chronic kidney disease(CKD) and its biomarker in the older adults, we established a cohort of 542 community-living seniors aged 85 years or older. In the cross-sectional analysis, we found that estimated gulomerular filtration ratios(eGFR) based on creatinine or cystatin C were associated with micro albuminuria, anemia, and parathyroid hormone ; however, only eGFR based on cystatin C was associated with carotid plaque, suggesting usefulness of cystatin C in detecting individuals at high risk for acardiovascular disease in this population.

Research Products

• [Journal Article] Maximum Occlusal Force and Physical Performance in the Oldest Old : The Tokyo Oldest Old Survey on Total Health(TOOTH) (2012)
  • Author(s): Iinuma, Arai Y, Fukumoto M, et al
  • Journal Title: J Am Geriatr Soc Volume: 60 Pages: 68-76
  • Peer Reviewed
• [Journal Article] 超高齢期におけるビタミンD欠乏症と生活習慣の関連についての検討 (2011)
  • Author(s): 高山美智代、住谷智恵子、新井康通
  • Journal Title: 未病と抗老化 Volume: 20 Pages: 113-116
  • Peer Reviewed
• [Journal Article] The Tokyo Oldest Old Survey on Total Health(TOOTH): a longitudinal cohort study of multidimensional components of health and well-being (2010)
  • Author(s): Arai Y, Iinuma T, Takayama M, et al
  • Journal Title: BMC Geriatr Volume: 9(10) Pages: 35
  • Peer Reviewed
• [Journal Article] Vitamin D deficiency and lifestyle factors in the oldest old (2010)
  • Author(s): Sumiya C, Arai Y, Takayama M, et al
  • Journal Title: J Am Geriatr Soc Volume: 58(11) Pages: 2242-2244
  • Peer Reviewed
• [Presentation] Overview of human longevity research (2012)
  • Author(s): Arai Y
  • Organizer: 2^<nd> International Congress on Gerontology and Geriatric Medicine
  • Place of Presentation: New Delhi
  • Year and Date: 2012-02-27
• [Presentation] 超高齢者における動脈硬化危険因子と頸動脈内中膜肥厚度の関連についての検討 (2011)
  • Author(s): 新井康通、住谷智恵子、高山美智代
  • Organizer: 第52回日本老年医学会学術集会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 20110624-26
• [Presentation] Cystatin C and Carotid Plaques in the community-living Women age 85 Years or Older (2011)
  • Author(s): Arai Y, Abe Y, Takayama M, et al
  • Organizer: 第43回日本動脈硬化学会総会・学術集会
  • Place of Presentation: ロイトン札幌(札幌)
  • Year and Date: 2011-07-16
• [Presentation] 都心部在住超高齢者における骨折と機能・QOL・虚弱との関連 (2010)
  • Author(s): 高山美智代、新井康通
  • Organizer: 第52回日本老年医学会学術集会
  • Place of Presentation: 神戸国際会議場(兵庫)
  • Year and Date: 20100624-26
• [Presentation] 超高齢期におけるビタミンD欠乏症の臨床的意義と生活習慣の関連について (2010)
  • Author(s): 住谷智恵子、高山美智代、新井康通
  • Organizer: 第52回日本老年医学会学術集会
  • Place of Presentation: 神戸国際会議場(兵庫)
  • Year and Date: 20100624-26
• [Presentation] 超高齢期における体重減少と精神的および身体的健康指標の関連について (2010)
  • Author(s): 新井康通、高山美智代
  • Organizer: 第52回日本老年医学会学術集会
  • Place of Presentation: 神戸国際会議場(兵庫)
  • Year and Date: 20100624-26
• [Presentation] Waist circumference and cardiovascular risk factors among the oldest old in Tokyo (2010)
  • Author(s): Arai Y, Takayama M, et al
  • Organizer: 第42回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 長良川国際会議場(岐阜)
  • Year and Date: 2010-07-16
• [Presentation] The relationship between GOHAI andhealth conditions of the oldest old (2009)
  • Author(s): Fukumoto M, Saito K, Iinuma T, Arai Y, et al
  • Organizer: The 19^<th> IAGG World Congress of Gerontology and Geriatrics
  • Place of Presentation: Paris
  • Year and Date: 2009-07-06
• [Presentation] Relationship between quality of life and clinical and psychological parameters among the oldest old in Tokyo (2009)
  • Author(s): Takayama M, Arai Y, et al
  • Organizer: The 19^<th> IAGG World Congress of Gerontology and Geriatrics
  • Place of Presentation: Paris
  • Year and Date: 2009-07-05
• [Presentation] The relationship between oral functions and mental status (2009)
  • Author(s): Iinuma T, Saito K, Fukumoto M, Arai Y, et al
  • Organizer: The 19^<th> IAGG World Congress of Gerontology and Geriatrics
  • Place of Presentation: Paris
  • Year and Date: 2009-07-05
• [Remarks] (1)慶應義塾大学医学部老年内科ホームページに本研究の成果の一部を公開している。
  • URL: http://www.keio-med.jp/rounen/
• [Remarks] (2)日経メディカルオンラインにて本研究成果が紹介された。
  • URL: http://medical.nikkeibp.co.jp/leaf/all/gakkai/jas2011/201107/520753.html
• [Remarks] (3)ラジオ日経にて超高齢者調査の一部が紹介された。
• [Remarks] (4)本研究成果は超高齢者のプライマリーケアを担当する開業医にとって貴重であり、地区医師会の勉強会で結果を報告した(新宿区医師会、渋谷区医師会)
• [Remarks] (5)本研究成果は一般の高齢者の健康維持にも有用であり、セミナー、卓話を行った。(東京日本橋東ロータリークラブ例会)