2011 Fiscal Year Final Research Report
Carcinogenic effect of nitric oxide generated luminally at gastro-esophageal junction of human
| Project/Area Number |
21590783
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 消化器内科学 |
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| Research Abstract |
At the human gastro-esophageal junction, nitric oxide (NO)is generated luminally during several hours after the ingestion of dietary nitrate. The present study demonstrated that exogenous luminal nitric oxide could be involved in the pathogenesis of reflux esophagitis and Barrett's esophagus, a precursor lesion of esophageal adenocarcinoma, and that the action caused by the NO presented the prominent gender difference. Since gender differences consistently exist in carcinogenesis at gastro-esophageal junction in human, understanding the mechanism by which action of NO on the esophageal epithelium could induce the gender difference should provide valuable information regarding the pathogenesis of esophageal adenocarcinoma.
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