2011 Fiscal Year Final Research Report
A study of motilin-induced gastric migrating motor complex.-A novel approach for using newly established animal model-
| Project/Area Number |
21590785
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Saitama University |
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Principal Investigator |
SAKAI Takafumi 埼玉大学, 大学院・理工学研究科, 教授 (40235114)
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| Co-Investigator(Kenkyū-buntansha) |
ADACHI Akihito 埼玉大学, 大学院・理工学研究科, 准教授 (20351588)
SAKATA Ichiro 埼玉大学, 大学院・理工学研究科, 助教 (80610831)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 上部消化管学(食道、胃、十二指腸) |
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| Research Abstract |
The suncus stomach and duodenum showed clear migrating phase III contractions(intervals of 80-150min)as found in humans and dogs. Exogenous motilin administration induced gastric phase III contractions, and motilin injection also increased the gastric motility index in a dose-dependent manner. Treatment of motilin antagonist inhibited the occurrence of phaseIII. Also, During the fasted state, cyclic MMC, consisting of phase I, II, and III were observed in both sham-operated and vagotomized suncus, but the duration and motility index(MI)of the phase II was significantly decreased in vagotomized suncus. In vagotomized suncus, feeing did not interrupt phase I of the MMC, and exogenous motilin induced strong phase III-like contractions as well as the fasted state.
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[Journal Article] Potentiation of ghrelin signaling attenuates cancer anorexia-cachexia and prolongs survival2011
Author(s)
Fujituka N, Asakawa A, Uezono Y, Minami K, Yamaguchi T, Niijima A, Yada T, Maejima Y, Sedbazar U, Sakai T, Hattori T, Kase Y, Inui A
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Journal Title
DOI
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[Journal Article] Fragments of Genomic DNA Released by Injured Cells Activate Innate Immunity and Suppress Endocrine Function in the Thyroid2011
Author(s)
Kawashima A, Tanigawa K, Akama T, Wu H, Sue M, Yoshihara A, Ishido Y, Kobiyama K, Takeshita F, Ishii K, Hirano H, Kimura H, Sakai T, Ishii N, Suzuki K
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Journal Title
Endocrinology
Volume: 152(4)
Pages: 1702-1712
DOI
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[Presentation] Motilin and ghrelin synergistically regulates migrating motor complex(MMC)of the gastrointestinal(GI)motility in the Suncus murinus(house musk shrew)2011
Author(s)
Mondal A, Xie Z, Miyano Y, Tsutsui C, Kawamoto Y, Aizawa S, Tanaka T, Oda S, Sakata I, Sakai T
Organizer
The 5th meeting of the Society of Gastrointestinal Intervention
Place of Presentation
Seoul, Korea
Year and Date
20111014-15
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[Presentation] Ghrelin stimulates gastric contraction in a specific physiological condition in vivo and in vitro in the house musk shrew(Suncus murinus)2010
Author(s)
Xie Z, Sakahara S, Hoshino S, Ishida Y, Suzuki A, Koike K, Miyano Y, Kodaira Y, Takahashi T, Oda S, Sakai T
Organizer
a ghrelin-and motilin-producing laboratory animal. 2010 Digestive Disease Week
Place of Presentation
New Orleans
Year and Date
20100501-05
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[Presentation] Proposal of a new model animal, house musk shrew(Suncus murinus), for study of the ghrelin/motilin family-stimulatory effect of ghrelin on gastric contraction in IMC2009
Author(s)
K Koike, S Sakahara, Z Xie, Y Ishida, S Hoshino, C Tsutsui, H Kaiya, T Takahashi, S Oda, T Sakai
Organizer
2009 International Symposium on Ghrelin
Place of Presentation
東京
Year and Date
20091118-20
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[Presentation] Establishment of a new model animal, the house musk shrew(Suncus murinus), for study of precise mechanisms of motilin-induced gastrointestinal contractions in vivo and in vitro2009
Author(s)
S Sakahara, C Tsutsui, T Yanaka, Y Ishida, K Koike, Z Xie, A Suzuki, H Kaiya, T Takahashi, T Hirata, T Sakai
Organizer
Neurogastroenterology and Motility
Place of Presentation
Chicago
Year and Date
20090827-30
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