2011 Fiscal Year Final Research Report
A role of adiponectin in the pathogenesis of GERD and the development of adenocarcinoma from Barrett' s esophagus
| Project/Area Number |
21590787
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka University |
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Principal Investigator |
KENJI Watabe 大阪大学, 医学系・研究科, 助教 (50379244)
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| Co-Investigator(Kenkyū-buntansha) |
TSUTSUI Shusaku 大阪大学, 医学系・研究科, 助教 (10359846)
KISO Shinnichi 大阪大学, 医学系・研究科, 助教 (40335352)
YOSHIDA Yuichi 大阪大学, 医学系・研究科, 助教 (30457014)
TSUJII Masahiko 大阪大学, 医学系・研究科, 准教授 (40303937)
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| Co-Investigator(Renkei-kenkyūsha) |
KIHARA Shinji 大阪大学, 医学系・研究科, 教授 (20332736)
HAMASAKI Toshimitsu 大阪大学, 医学系・研究科, 准教授 (40379243)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 胃炎 / 食道炎 / 食道癌 / 肥満 / アディポネクチン |
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| Research Abstract |
It has been recently demonstrated that obesity is related to the esophagitis and gastritis. Obesity is also reported to associate with adenocarcinoma arised from Barrett epithelium of the esophagus. In this study, we intended to clarify whether adiponectin(APN) secreted from adipose tissue is involved in these steps. 1) Clinical study. We analyzed medical records of participants of a routine health check-up examination. Lower serum level of APN is associated with an increased risk for erosive esophagitis as well as erosive gastritis. 2) Animal experimental study using APN knockout mice(APN-KO). We first failed to demonstrate the surgical model of reflux esophagitis due to technical reasons. We then examined the gastric injury induced by oral administration of ethanol(EtOH), and showed that severe gastric injury was induced in APN-KO accompanied by the impaired induction of PGE_2 in the injured stomach. 3) Cell culture study using rat gastric mucosal cells(RGM1). APN induced the expression level of PGE_2 in RGM1 cell treated with EtOH. RGM1 cells exhibited efficient wound repair accompanied by increased PGE_2 expression in the presence of adiponectin that is inhibited by coadministration with celecoxib, a COX-2 inhibitor. Collectively, APN showed protective effect in gastric injury induced by EtOH which may be partially mediated by the efficient wound repair of epithelial cells through increased PGE_2 expression.
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[Journal Article] Protective role of adiponectin against ethanol-induced gastric injury in mice2012
Author(s)
Yamamoto S, Watabe K, Araki H, Kamada Y, Kato M, Kizu T, Kiso S, Tsutsui S, Tsujii M, Kihara S, et al.
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Journal Title
Am J Physiol Gastrointest Liver Physiol
Volume: 302(8)
Pages: G773-780
Peer Reviewed
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[Journal Article] Association of low serum adiponectin levels with erosive esophagitis in men : an analysis of 2405 subjects undergoing physical check-ups2011
Author(s)
Kato M, Watabe K, Hamasaki T, Umeda M, Furubayashi A, Kinoshita K, Kishida O, Fujimoto T, Yamada A, Tsukamoto Y, Yamamoto S, Kamada Y, Yoshida Y, Kiso S, Tsutsui S, Kihara S, et al.
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Journal Title
J Gastroenterol
Volume: 46
Pages: 1361-1367
Peer Reviewed
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