Investigation of the effects of CagA on phenotype using microRNA array analysis

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590788
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Osaka University
• Principal Investigator: TSUJII Masahiko 大阪大学, 医学系・研究科, 准教授 (40303937)
• Co-Investigator(Kenkyū-buntansha): IIJIMA Hideki 大阪大学, 大学院・医学系研究科, 助教 (90444520) ; NISHIDA Tsutomu 大阪大学, 大学院・医学系研究科, 助教 (20467575)
• Project Period (FY): 2009 – 2011
• Keywords: microRNA / ヘリコバクター / CagA / 胃癌

Research Abstract

In the cultured epithelial cells derived from gastric mucosa and the gastric epithelial cells of transgenic mice, H. pylori-CagA accelerated Ras expression via aberrant methylation of DNA and histone and resultant let-7 expression downregulation. These results indicated that aberrant methylation in histone and DNA and dysregulated microRNA expression play a pivotal role in CagA-related carcinogenesis.

Research Products

• [Journal Article] Search for novel target molecules for the effective treatment or prevention of colorectal cancer (2012)
  • Author(s): Tsujii M.
  • Journal Title: Digestion Volume: 85(2) Pages: 99-102
  • Peer Reviewed
• [Journal Article] Protective role of adiponectin against ethanol-induced gastric injury in mice (2012)
  • Author(s): Yamamoto S, Watabe K, Araki H, Tsujii M, et al.
  • Journal Title: Am J Physiol Gastrointest Liver Physiol Volume: 302(8) Pages: G773-80
  • Peer Reviewed
• [Journal Article] Treatment strategy for gastric non-invasive intraepithelial neoplasia diagnosed by endoscopic biopsy (2012)
  • Author(s): Nishida T, Tsutsui S, Iijima H, Tsujii M, et al.
  • Journal Title: World J Gastrointest Pathophysiol Volume: 2 Pages: 93-99
  • Peer Reviewed
• [Journal Article] Altered Oligosaccharide Structures Reduce Colitis Induction in Mice Defective in beta-1, 4-Galactosyltransferase (2012)
  • Author(s): Shinzaki S, Iijima H, Tsujii M, et al.
  • Journal Title: Gastroenterology Volume: 142 Pages: 1172-1182
  • Peer Reviewed
• [Journal Article] Deficiency of N-acetylgalactosamine in O-linked oligosaccharides of IgA is a novel biologic marker for Crohn' s disease (2012)
  • Author(s): Inoue T, Iijima H, Nishida T, Tsujii M, et al.
  • Journal Title: Inflamm Bowel Dis Volume: (in press)
  • Peer Reviewed
• [Journal Article] Schistosoma japonicum showing flat colon polyp appearance (2011)
  • Author(s): Abe T, Yunokizaki H, Iijima H, Tsujii M, et al.
  • Journal Title: Gastrointest Endosc Volume: 73 Pages: 820-822
  • Peer Reviewed
• [Journal Article] Endoscopic submucosal dissection as a treatment for gastric noninvasive neoplasia : a multicenter study by Osaka University ESD Study Group (2011)
  • Author(s): Kato M, Nishida T, Tsutsui S, Iijima H, Tsujii M, et al.
  • Journal Title: J Gastroenterol Volume: 46 Pages: 325-331
  • Peer Reviewed
• [Journal Article] Short-term outcomes of endoscopic submucosal dissection(ESD) for early gastric neoplasm : multicenter survey by osaka university ESD study group (2011)
  • Author(s): Akasaka T, Nishida T, Iijima H, Tsujii M, et al.
  • Journal Title: Dig Endosc Volume: 23 Pages: 73-77
  • Peer Reviewed
• [Journal Article] Retaining cell-cell contact enables preparation and culture of spheroids composed of pure primary cancer cells from colorectal cancer (2011)
  • Author(s): Kondo J, Endo H, Okuyama H, Tsujii M, et al.
  • Journal Title: Proc Natl Acad Sci USA Volume: 108 Pages: 6235-6240
  • Peer Reviewed
• [Journal Article] Association of vitamin K deficiency with bone metabolism and clinical disease activity in inflammatory bowel disease (2011)
  • Author(s): Nakajima S, Iijima H, Egawa S, Nishida T, Kanto T, Tsujii M, et al.
  • Journal Title: Nutrition Volume: 27 Pages: 1023-1028
  • Peer Reviewed
• [Journal Article] Comparative analysis of the effects of anti-IL-6 receptor mAb and anti-TNF mAb treatment on CD4+ T-cell responses in murine colitis (2011)
  • Author(s): Terabe F, Fujimoto M, Serada S, Shinzaki S, Iijima H, Tsujii M, et al.
  • Journal Title: Inflamm Bowel Dis Volume: 17 Pages: 491-502
  • Peer Reviewed
• [Journal Article] Search for molecular marker/ target molecule useful for colorectal cancer treatment (2011)
  • Author(s): Tsujii M, Iijima H, Takehara T.
  • Journal Title: Nihon Shokakibyo Gakkai Zasshi Volume: 108 Pages: 1354-1362
  • Peer Reviewed
• [Journal Article] Functional analysis of agalactosyl IgG in inflammatory bowel disease patients (2010)
  • Author(s): Nakajima S, Iijima H, Shinzaki S, Nishida T, Tsujii M, et al.
  • Journal Title: Inflamm Bowel Dis Volume: 17 Pages: 927-936
  • Peer Reviewed
• [Journal Article] Roles of double-balloon endoscopy in the diagnosis and treatment of Crohn' s disease : a multicenter experience (2010)
  • Author(s): Kondo J, Iijima H, Abe T, Tsujii M, et al.
  • Journal Title: J Gastroenterol Volume: 45 Pages: 713-720
  • Peer Reviewed
• [Journal Article] Collision tumor of a carcinoid and carcinoma in the rectum (2010)
  • Author(s): Kato M, Nishida T, Tsutsui S, Iijima H, Takemasa I, Hiramatsu N, Tsujii M, et al.
  • Journal Title: Nihon Shokakibyo Gakkai Zasshi Volume: 107 Pages: 61-69
  • Peer Reviewed
• [Journal Article] Phase I trial of gemcitabine dose escalation with concurrent radiotherapy for patients with locally advanced pancreatic cancer (2010)
  • Author(s): Nishida T, Tsutsui S, Yamamoto K, Iijima H, Tsujii M, Takeda Y, et al.
  • Journal Title: Pancreatology Volume: 10 Pages: 60-65
  • Peer Reviewed
• [Journal Article] MRTF-A/ B suppress the oncogenic properties of v-ras-and v-src-mediated transformants (2010)
  • Author(s): Yoshio T, Morita T, Tsujii M, et al.
  • Journal Title: Carcinogenesis Volume: 31 Pages: 1185-93
  • Peer Reviewed
• [Journal Article] Metastatic breast cancer mimicking primary depressed gastric cancer (2009)
  • Author(s): Abe T, Yoshidome K, Iijima H, Tsujii M, et al.
  • Journal Title: Gastrointest Endosc Volume: 70 Pages: 1241-1242
  • Peer Reviewed
• [Journal Article] Restoration of gut motility in Kit-deficient mice by bone marrow transplantation (2009)
  • Author(s): Ishii S, Tsuji S, Tsujii M, Nishida T, Watabe K, Iijima H, et al.
  • Journal Title: J Gastroenterol Volume: 44 Pages: 834-841
  • Peer Reviewed
• [Presentation] Cyclooxygenase-2の癌幹細胞バイオロジー、DNA異常メチル化に及ぼす影響 (2012)
  • Author(s): 辻井正彦、近藤純平、赤坂智史、林義人、金瑛、加藤元彦、山本俊祐、井上拓也、山田拓哉、西田勉、渡部健二、飯島英樹、竹原徹郎
  • Organizer: 第8回日本消化管学会総会
  • Place of Presentation: 宮城
  • Year and Date: 2012-02-10
• [Presentation] ヘリコバクターピロリ起因性発癌におけるEZH2の重要性 (2011)
  • Author(s): 林義人、辻井正彦、赤坂智史、近藤純平、考藤達哉、竹原徹郎
  • Organizer: 日本癌学会
  • Place of Presentation: 愛知
  • Year and Date: 2011-10-05
• [Presentation] Cyclooxygenase-2はDNA異常メチル化を惹起し、癌幹細胞の機能に影響を与える (2011)
  • Author(s): 辻井正彦、井上拓也、山本俊祐、加藤元彦、林義人、赤坂智史、近藤純平、渡部健二、西田勉、飯島英樹、筒井秀作、竹原徹郎
  • Organizer: 日本癌学会
  • Place of Presentation: 愛知
  • Year and Date: 2011-10-03
• [Presentation] 炎症性腸疾患におけるIgAO結合型糖査異常の機序について (2011)
  • Author(s): 井上隆弘、飯島英樹、白石衣里, 他
  • Organizer: 第97回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-13
• [Presentation] 症性腸疾患患者におけるMannan Binding Lectinの分布とガラクトース欠損IgGの役割 (2010)
  • Author(s): 中島佐知子、飯島英樹、向井章、井上隆弘、新崎信一郎、柄川悟志、赤坂智史、林義人、近藤純平、西田勉、辻井正彦、林紀夫
  • Organizer: JDDW
  • Place of Presentation: 横浜
  • Year and Date: 20101013-16
• [Presentation] 自己免疫膵炎の治療と予後 (2010)
  • Author(s): 西田勉、筒井秀作、重川稔、柄川悟志、飯島英樹、辻井正彦、林紀夫
  • Organizer: JDDW
  • Place of Presentation: 横浜
  • Year and Date: 20101013-16
• [Presentation] 食道癌術後再建胃管腫瘍に対する内視鏡的粘膜下層剥離術の検討 (2010)
  • Author(s): 荻山秀治;筒井秀作;赤坂智史;加藤元彦;山本俊祐;林義人;西田勉;渡部健二;飯島英樹;辻井正彦;林紀夫
  • Organizer: JDDW
  • Place of Presentation: 横浜
  • Year and Date: 20101013-16
• [Presentation] 長期観察例からみた分枝型膵IPMNの手術適応に関する検討 (2010)
  • Author(s): 西田勉、筒井秀作、柄川悟志、飯島英樹、辻井正彦、林紀夫
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟
  • Year and Date: 20100421-24
• [Presentation] 進行膵癌(cStageIV)に対する治療戦略 (2010)
  • Author(s): 柄川悟志、西田勉, 重川稔、飯島英樹、筒井秀作, 辻井正彦, 林紀夫
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟
  • Year and Date: 20100421-24
• [Presentation] 長期生存に寄与する臨床的因子に基づいた胃癌化学療法 (2010)
  • Author(s): 西田勉、筒井秀作, 柄川悟志, 飯島英樹, 辻井正彦, 林紀夫
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟
  • Year and Date: 20100421-24
• [Presentation] ガラクトース転移酵素欠損マウスB細胞の腸炎保護作用 (2010)
  • Author(s): 新崎信一郎、飯島英樹、竜中法佳、黒木絵莉、向井章、井上隆弘、中島佐知子、柄川悟志、考藤達哉、辻井正彦、三善英知、林紀夫
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟
  • Year and Date: 20100421-24
• [Presentation] 炎症性腸疾患患者におけるMannan Binding Lectinの分布とガラクトース欠損IgGの役割 (2010)
  • Author(s): 中島佐知子、飯島英樹、日山智史、白石衣里、向井章、井上隆弘、新崎信一郎、赤坂智史、林義人、近藤純平、西田勉、辻井正彦
  • Organizer: 日本潰瘍学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-11-20
• [Presentation] 好酸球性胃腸炎に併発した急性膵炎による膵性胸水に内視鏡的膵管ドレナージが有効であった1例 (2010)
  • Author(s): 向井香織, 西田勉, 筒井秀作, 山田拓哉、植村彰夫、宮略昌典, 薬師神崇行, 新崎信一郎, 渡部健二, 飯島英樹, 望月圭平, 松直樹、辻井正彦, 竹原徹郎、池添世理子
  • Organizer: 第93回日本消化器病学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-18
• [Presentation] 関節炎を合併した治療抵抗性の潰瘍性大腸炎にInfliximabが著効した1例 (2010)
  • Author(s): 渋川成弘, 西田勉, 筒井秀作, 山田拓哉、植村彰夫, 新崎信一郎, 宮崎昌典, 薬師神崇行、飯島英樹, 望月圭, 平松直樹, 辻井正彦、竹原徹郎
  • Organizer: 第93回日本消化器病学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-18
• [Presentation] 小腸移植10年後に出現した下痢に対し小腸内視鏡観察が有用であった1症例 (2010)
  • Author(s): 日山智史、西田勉、柄川悟志、荒木浩士、渡部健二、飯島英樹、筒井秀作、辻井正彦、林紀夫
  • Organizer: 第84回日本消化器内視鏡学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-13
• [Presentation] インフリキシマブが著効した腸管型ベーチェット病の一例 (2010)
  • Author(s): 白石衣里、西田勉、飯島英樹、柄川悟志、荒木浩士、渡部健二、筒井秀作、辻井正彦、竹原徹郎、林紀夫
  • Organizer: 第84回日本消化器内視鏡学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-13
• [Presentation] Regulation of oligosaccharide-associated enzymes by Infliximab In B cells of Crohn' s disease (2010)
  • Author(s): S. Shinzaki, H. Iijima, N. Tatsunaka, S. Egawa, S. Nakajima, T. Inoue, A. Mukai, M. Tsujii, E. Miyoshi, N. Hayashi
  • Organizer: The 4th Korea-Japan Inflammatory Bowel Disease Symposium
  • Place of Presentation: 東京
  • Year and Date: 2010-01-23
• [Presentation] NSAIDsの抗腫瘍効果 (2009)
  • Author(s): 辻井正彦
  • Organizer: 第13回壁細胞研究会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-14
• [Presentation] Novel PKA-targeting therapy based on cancer stem cell biology (2009)
  • Author(s): Tsujii M, Hayashi Y, Kondo J, Kanto T, Takehara T, Hayashi N.
  • Organizer: 第68回日本癌学会学術総
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] CagA induces hypermetylation of microRNA let-7 promoter to increase Ras expression (2009)
  • Author(s): Yoshito Hayashi, Masahiko Tsujii, Jumpei Kondo, Tatsuya Kanto, Tetsuo Takehara, Norio Hayashi
  • Organizer: 8回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] 食道偽憩室症の一例 (2009)
  • Author(s): 椿尾真弓;西田勉;山本俊祐;中島佐知子;柄川悟志;荒木浩士;渡部健二;飯島英樹;筒井秀作;辻井正彦;竹原徹郎;林紀夫
  • Organizer: 第83回日本消化器内視鏡学会近畿地方会
  • Place of Presentation: 京都
  • Year and Date: 2009-09-19
• [Presentation] 当院における内視鏡下腹腔神経叢ブロックの経験 (2009)
  • Author(s): 松本健吾;西田勉;重川稔;柄川悟志;宇田創;福武信康;荒木浩士;渡部健二;飯島英樹;筒井秀作;辻井正彦;竹原徹郎;林紀夫
  • Organizer: 第83回日本消化器内視鏡学会近畿地方会
  • Place of Presentation: 京都
  • Year and Date: 2009-09-19
• [Presentation] グライコミクスを用いた炎症性腸疾患診断・治療の可能性 (2009)
  • Author(s): 新崎信一郎、飯島英樹、柄川悟志、中島佐知子、井上隆弘、考藤達哉、三善英知、辻井正彦、林紀夫
  • Organizer: JDDW 2009
  • Place of Presentation: 京都
  • Year and Date: 2009-09-19
• [Presentation] 早期胃癌におけるプローブ型超音波内視鏡による深達度診断 (2009)
  • Author(s): 山本俊祐、西田勉、筒井秀作、加藤元彦、林義人、荻山秀治、山田拓哉、渡部健二、飯島英樹、辻井正彦、竹原徹郎、林紀夫
  • Organizer: JDDW 2009
  • Place of Presentation: 京都
  • Year and Date: 2009-09-19
• [Presentation] 炎症性腸疾患におけるIgG糖鎖異常血清学的マーカーとしての有用性に関する検討 (2009)
  • Author(s): 新崎信一郎、飯島英樹、向井章、井上隆弘、中島佐知子、柄川悟志、考藤達哉、三善英知、辻井正彦、林紀夫
  • Organizer: 日本臨床検査医学会
  • Place of Presentation: 札幌
  • Year and Date: 2009-08-26
• [Presentation] 炎症性腸疾患患者の診断および治療に対するIgG糖鎖構造解析の有用性 (2009)
  • Author(s): 飯島英樹、新崎信一郎、黒木絵莉、柄川悟志、中島佐知子、井上隆弘、向井章、考藤達哉、三善英知、辻井正彦、林紀夫
  • Organizer: 第46回消化器免疫学会
  • Place of Presentation: 松山
  • Year and Date: 2009-07-23
• [Presentation] 炎症性腸疾患におけるVitamin KとRANKLの骨密度および疾患活動性との関連 (2009)
  • Author(s): 中島佐知子, 飯島英樹, 向井章, 井上隆弘, 新崎信一郎, 柄川悟志, 赤坂智史, 林義人, 近藤純平, 西田勉, 筒井秀作, 辻井正彦, 林紀夫
  • Organizer: 大阪骨代謝研究会
  • Place of Presentation: 大阪
  • Year and Date: 2009-06-22
• [Presentation] Hypermethylation of Let-7 Promoter Is Involved in cagA-Induced RAS Upregulation in Gastric Epithelial Cells (2009)
  • Author(s): Y. Hayashi, S. T. Masahiko Tsujii, Ying Jin, Takahiro Inoue, Jumpei Kondo, Sachiko Nakajima, Toshiyuki, S. I. Yoshio, Shinichiro Shinzaki, Satoshi Egawa, Tsutomu Nishida, Kenji Watabe, Hideki Iijima, Shusaku Tsutsui, , T. T. Sunao Kawano, Norio Hayashi
  • Organizer: 米国DDW
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-05-30
• [Presentation] Clinical Factors Influence Accurate Endosonographic Assessment with Miniprobe for Early Gastric Cancer (2009)
  • Author(s): S. Yamamoto, T. Nishida, S. Tsutsui, M. Kato, Y. Hayashi, T. Yamada, H. Ogiyama, T. Yoshio, H. Iijima, M. Tsujii, N. Hayashi
  • Organizer: 米国DDW
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-05-30
• [Presentation] Restoration of Gut Motility in Kit-Deficient Mice By Bone Marrow (2009)
  • Author(s): S. Ishii, S. Tsuji, M. Tsujii, T. Nishida, K. Watabe, H. Iijima, T. Takehara, S. Kawano, N. Hayashi
  • Organizer: 米国DDW
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-05-30
• [Presentation] Deficiency of Galactosyltransferase, Indispensable Enzyme for IgG Galactosylation, Ameliorates Murine Dextran (2009)
  • Author(s): S. Shinzaki, H. Iijima, S. Egawa, S. Nakajima, T. Inoue, Y. Jin, Y. Hayashi, J. Kondo, S. Ishii, T. Nishida, T. Kanto, E. Miyoshi, M. Tsujii, N. Hayashi
  • Organizer: 米国DDW
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-05-30
• [Presentation] Novel PKA-Targeting Therapy Based On Cancer Stem Cell Biology (2009)
  • Author(s): M. Tsujii, J. Kondo, Y. Jin, T. Nishida, Y. Hayashi, S. Ishii, Y. Hayashi, T. Yoshio, S. Egawa, S. Shinzaki, T. Inoue, S. Nakajima, K. Watabe, H. Iijima, S. Tsutsui, N. Hayashi
  • Organizer: 米国DDW
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-05-30
• [Presentation] Oligosaccharide Alterations in IgG in Inflammatory Bowel Disease Is Not Associated with MBL Lectin (2009)
  • Author(s): H. Iijima, S. Nakajima, S. Shinzaki, S. Egawa, T. Inoue, Y. Hayashi, J. Kondo, S. Ishii, T. Yoshio, T. Nishida, T. Kanto, E. Miyoshi, M. Tsujii, N. Hayashi
  • Organizer: DDW
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-05-30
• [Presentation] Postoperative Pneumonia Associated with ESD Is Increased in Elderly Patients with Upper Gastrointestinal (2009)
  • Author(s): H. Ogiyama, T. Nishida, S. Tsutsui, T. Yamada, T. Michida, S. Kitamura, M. Ichiba, M. Komori, O. Nishiyama, F. Nakanishi, S. Zushi, M. Yura, H. Iijima, M. Tsujii
  • Organizer: 米国DDW
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-05-30
• [Presentation] Correlation Between Vitamin K Deficiency and Clinical Activity Index in Patients with Inflammatory Bowel (2009)
  • Author(s): S. Nakajima, H. Iijima, T. Inoue, S. Shinzaki, S. Egawa, Y. Hayashi, J. Kondo, S. Ishii, T. Yoshio, K. Watabe, T. Nishida, M. Tsujii, S. Tsutsui, N. Hayashi
  • Organizer: 米国DDW
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-05-30
• [Presentation] 早期胃癌におけるプローブ型超音波内視鏡による深達度診断 (2009)
  • Author(s): 山本俊祐、筒井秀作、西田勉、加藤元彦、林義人、山田拓哉、荻山秀治、由雄敏之、飯島英樹、辻井正彦、林紀夫
  • Organizer: 第77回日本消化器内視鏡学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-05-21
• [Presentation] 炎症性腸疾患におけるIgG糖鎖異常ーガラクトース転移酵素欠損マウスを用いた解析 (2009)
  • Author(s): 新崎信一郎、飯島英樹、井上隆弘、中島佐知子、柄川悟志、石井修二、考藤達哉、三善英知、辻井正彦、林紀夫
  • Organizer: 第95回日本消化器病学会
  • Place of Presentation: 札幌
  • Year and Date: 2009-05-07
• [Presentation] 炎症性腸疾患患者における低カルボキシル化オステオカルシン(ucOC)の骨密度および疾患活動性との相関 (2009)
  • Author(s): 中島佐知子、飯島英樹、井上隆弘、新崎信一郎、柄川悟志、林義人。近藤純平、石井修二、西田勉、筒井秀作、辻井正彦、林紀夫
  • Organizer: 第95回日本消化器病学会
  • Place of Presentation: 札幌
  • Year and Date: 2009-05-07
• [Presentation] 消化器癌悪性腹水に対するtriamcinolone腹腔内投与の症状緩和効果 (2009)
  • Author(s): 林義人、西田勉、筒井秀作、山本貴洋、飯島英樹、辻井正彦、竹原徹朗、林紀夫
  • Organizer: 第95回日本消化器病学会
  • Place of Presentation: 札幌
  • Year and Date: 2009-05-07
• [Presentation] 胃良性・悪性境界病変に対する内視鏡的粘膜下層剥離術の妥当性 (2009)
  • Author(s): 加藤元彦, 西田勉、山田拓哉, 荻山秀治, 由雄敏之, 山本俊祐, 林義人, 渡部健二, 飯島英樹, 筒井秀作, 辻井正彦, 林紀夫
  • Organizer: 第95回日本消化器病学会
  • Place of Presentation: 札幌
  • Year and Date: 2009-05-07