Analysis of homing system for bone marrow derived cells into gastric cancer tissues through MCP-1 stimulation

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590796
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Nippon Medical School
• Principal Investigator: FUTAGAMI Seiji 日本医科大学, 医学部, 助教 (50247011)
• Co-Investigator(Kenkyū-buntansha): SAKAMOTO Choitsu 日本医科大学, 医学部, 教授 (30196092)
• Project Period (FY): 2009 – 2011
• Keywords: Bone marrow derived cells / MCP-1 / migration / CD133-/CD44-positive cell

Research Abstract

We conformed that CD133-/CD44-positive cells were migrated into the gastric cancer tissues. In addition, we found that CD133-/CD44-positive cells infiltrated in the ascites of the patients with advanced gastric cancer tissues. MCP-1 significantly inhibited the migration of these cells using migration assay.

Research Products

• [Journal Article] G-proteinβ3 subunit 825CC genotype is associated with postprandial distress syndrome with impaired gastric emptying and with the feeling of hunger in Japanese (2011)
  • Author(s): S himpuku M, Futagami S, Kawagoe T, Nagoya H, Shindo T, Horie A, Kodaka Y, Itoh T, Sakamoto C
  • Journal Title: Neurogastroenterol Motil Volume: 23 Pages: 1073-1080
  • DOI: doi:10.1111/j.1365-2982.2011.01781.x.
  • Peer Reviewed
• [Journal Article] Pathophysiology of functional dyspepsia (2011)
  • Author(s): Futagami S, Shimpuku M, Yin Y, Shindo T, Kodaka Y, Nagoya H, Nakazawa S, Fujimoto M, Izumi N, Ohishi N, Kawagoe T, Horie A, Iwakiri K, Sakamoto C
  • Journal Title: J Nihon Med Sch Volume: 78 Pages: 280-285
  • DOI: Doi:10.1272/jnms.78.280
  • Peer Reviewed
• [Journal Article] The incidence of deep vein thrombosis in Japanese patients undergoing endoscopic submucosal dissection (2011)
  • Author(s): K usunoki M, Miyake K, Shindo T, Ueki N, Kawagoe T, Gudis K, Futagami S, et al
  • Journal Title: Gastrointest Endosc Volume: 74 Pages: 798-804
  • DOI: Doi:10.1016/j.gie.2011.06.015
  • Peer Reviewed
• [Journal Article] The effects of nizatidine on transient lower esophageal sphincter relaxations(TLESRs) and acid reflux in healthy subjects (2011)
  • Author(s): Iwakiri K, Kawami N, Sano H, Tanaka Y, Umezawa M, Futagami S, et al
  • Journal Title: J Smooth Muscle Res Volume: 47 Pages: 157-166
  • DOI: Doi:10.1540/jsmr.47.157
  • Peer Reviewed
• [Journal Article] 機能性ディスペプシアの病態生理胃排出能と遺伝子多型 (2011)
  • Author(s): 新福摩弓, 二神生爾, 北村忠弘, 坂本長逸
  • Journal Title: 日本臨床生理学会雑誌 Volume: 41 Pages: 87-93
  • Peer Reviewed
• [Journal Article] Characteristics of symptomatic reflux episodes in patients with non-erosivereflux disease who have a positive symptom index on proton pump inhibitor therapy (2010)
  • Author(s): Iwakiri K, Sano H, Tanaka Y, Kawami N, Umezawa M, Futagami S, et al
  • Journal Title: Digestion Volume: 82(3) Pages: 156-61
  • DOI: DOI:10.1159/000309483
  • Peer Reviewed
• [Journal Article] Migration of eosinophils and CCR2-/CD68-double positive cells into the duodenal mucosa of patients with postinfectious functional dyspepsia (2010)
  • Author(s): Futagami S, Shindo T, Kawagoe T, Horie A, Shimpuku M, Gudakamoto C
  • Journal Title: Am J Gastroenterol Volume: 105 Pages: 1835-1842
  • DOI: doi:10.1038/ajg.2010.151
  • Peer Reviewed
• [Journal Article] Celecoxib inhibits CD133-positive cell migration via reduction of CCR2 in Helicobacter pylori-infected Mongolian gerbils (2010)
  • Author(s): Futagami S, Hamamoto T, Shimpuku M, Nagoya H, Kawagoe T, Horie A, Shindo T, Gudis K, Sakamoto C
  • Journal Title: Digestion Volume: 81 Pages: 193-203
  • DOI: DOI:10.1159/000252790
  • Peer Reviewed
• [Journal Article] The prokinetic effect of mosapride citrate combined with omeprazole therapy improves clinical symptoms and gastric emptying in PPI-resistant NERD patients with delayed gastric emptying (2010)
  • Author(s): Futagami S, Iwakiri K, Shindo T, Kawagoe T, Horie A, Shimpuku M, Tanaka Y, Kawami N, Gudis K, Sakamoto C
  • Journal Title: J Gastroenterol Volume: 45 Pages: 413-421
  • DOI: DOI:10.1007/s00535-009-0173-0
  • Peer Reviewed
• [Journal Article] Nizatidine improves clinical symptoms and gastric emptying in the patients with functional dyspepsia accompanying with impaired gastric emptying
  • Author(s): Futagami S, et al
  • Journal Title: Digestion Volume: (in press)
  • Peer Reviewed
• [Presentation] 食道癌組織におけるApurinic/apyrimidinic endonuclease-1発現意義の解析 (2012)
  • Author(s): 名児耶浩幸、二神生爾、河越哲郎、小高康裕、新福摩弓, 他
  • Organizer: 第8回日本消化管学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2012-02-10
• [Presentation] 機能性ディスペプシア患者における空腹感スコアとghrelin, preproghrelinの遺伝子多型との相関関係の解析 (2012)
  • Author(s): 二神生爾、新福摩弓、坂本長逸
  • Organizer: 第8回日本消化管学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2012-02-10
• [Presentation] Celecoxib inhibits CD133-positive cell migration via reduction of CCR2 in Helicobacter pylori-infected Mongolian gerbils (2011)
  • Author(s): Kodaka Y, Futagami S, et al
  • Organizer: Digestive Disease Week
  • Place of Presentation: Chicago, USA
  • Year and Date: 20110507-10
• [Presentation] 食道癌組織におけるapurinic/apyrimidinic endonuclease-1(APE-1)発現の解析 (2011)
  • Author(s): 名児耶浩幸、二神生爾、河越哲郎、小高康裕、新福摩弓, 他
  • Organizer: 第97回日本消化器病学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-14
• [Presentation] H. pylori陽性胃炎患者に対するCOX-2遺伝子多型を用いたハイリスク群の絞り込みの検討 (2011)
  • Author(s): 小高康裕、二神生爾、河越哲郎、名児耶浩幸、新福摩弓, 他
  • Organizer: 第97回日本消化器病学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-14
• [Presentation] 感染後FD患者における十二指腸粘膜局所の炎症細胞浸潤と胃排出能の解析 (2011)
  • Author(s): 二神生爾、新福摩弓、坂本長逸
  • Organizer: 第97回日本消化器病学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-14
• [Presentation] Nizatidine administration improves clinical symptoms and gastric emptying of the patients with functional dyspepsia accompanying with impaired gastric emptying (2011)
  • Author(s): Futagami S, Shimpuku M, Kodaka Y, et al.
  • Organizer: Digestive Disease Week
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-05-07
• [Presentation] Migration of eosinophils and CCR2-/CD68-double positive cells into the duodenal mucosa of patients with post-infectious functional dyspepsia (2011)
  • Author(s): Futagami S, Shimpuku M, Kawagoe T, Kusunoki M, et al
  • Organizer: Digestive Disease Week
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-05-07
• [Presentation] H. pylori胃癌モデルおよびヒト胃癌組織におけるCD133陽性細胞発現の検討 (2010)
  • Author(s): 二神生爾, 他
  • Organizer: 第16回日本ヘリコバクター学会
  • Place of Presentation: 京都
  • Year and Date: 2010-06-24
• [Book] FD診察Q & A (2011)
  • Author(s): 新福摩弓、二神生爾、坂本長逸
  • Total Pages: 160
  • Publisher: 日本医事新報社
• [Book] 症候群ハンドブック (2011)
  • Author(s): 二神生爾
  • Total Pages: 757
  • Publisher: 中山書店