2011 Fiscal Year Final Research Report
Therapeutic approaches targeting colonic myofibroblasts-derived IL-24 in inflammatory bowel disease.
| Project/Area Number |
21590809
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
ANDO Akira 滋賀医科大学, 大学院・医学系研究科, 教授 (90252395)
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| Project Period (FY) |
2009 – 2011
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| Keywords | サイトカイン / 炎症性腸疾患 / 粘膜免疫 |
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| Research Abstract |
we demonstrated that IL-24 expression is enhanced in the inflamed mucosa of active IBD patients. Colonic SEMFs-derived IL-24 appears to play a protective role in the pathophysiology of IBD via a stimulation of STAT3 activation in cells mediating the innate immune response.
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