2011 Fiscal Year Final Research Report
Development of stem cell therapy for colitis and colitis-associated carcinogenesis
| Project/Area Number |
21590819
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MOTOYA Masayo (HOSOKAWA Masayo) 札幌医科大学, オホーツク医療環境研究講座, 特任助教 (60468080)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 下部消化管学(小腸,大腸) |
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| Research Abstract |
The therapeutic action of MSC remains to be clarified although mesenchymal stem cell(MSC) therapy was effective for rodent experimental colitis with low engraftment. Paracrine effects with pleiotropic gut trophic factors identified in the MSC conditioned medium were paramount importance as for its therapeutic action. MSC promoted xenografting tumor proliferation with MSC-dependent angiogenesis while MSC partially cancel azoxymethane-induced tumor initiation in systemic administration.
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[Journal Article] Myogenic lineage differentiated mesenchymal stem cells enhance recovery from dextran sulfate sodium-induced colitis in the rat2011
Author(s)
Tanaka H, Arimura Y, Yabana T, Goto A, Hosokawa M, Nagaishi K, Yamashita K, Yamamoto H, Sasaki Y, Fujimiya M, Imai K, Shinomura Y
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Journal Title
J Gastroenterol
Volume: 46
Pages: 143-152
Peer Reviewed
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[Journal Article] A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population2009
Author(s)
Asano K, Matsushita T, Umeno J, Hosono N, Takahashi A, Kawaguchi T, Matsumoto T, Matsui T, Kakuta Y, Kinouchi Y, Shimosegawa T, Hosokawa M, Arimura Y, Shinomura Y, Kiyohara Y, Tsunoda T, Kamatani N, Iida M, Nakamura Y, Kubo M
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Journal Title
Nat Genet
Volume: 41
Pages: 1325-1329
Peer Reviewed
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[Journal Article] Genetic variants in surfactant, pulmonary-associated protein D(SFTPD) and Japanese susceptibility to ulcerative colitis2009
Author(s)
Tanaka M, Arimura Y, Goto A, Hosokawa M, Nagaishi K, Yamashita K, Yamamoto H, Sonoda T, Nomura M, Motoya S, Imai K, Shinomura Y
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Journal Title
Inflamm Bowel Dis
Volume: 15
Pages: 918-925
Peer Reviewed
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[Journal Article] Enhancing epithelial engraftment of rat mesenchymal stem cells restores epithelial barrier integrity2009
Author(s)
Yabana T, Arimura Y, Tanaka H, Goto A, Tanaka M, Hosokawa M, Nagaishi K, Yamashita K, Yamamoto H, Adachi Y, Isobe M, Fujimiya M, Imai K, Shinomura Y
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Journal Title
J Pathol
Volume: 218
Pages: 350-359
Peer Reviewed
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[Presentation] Enhancing mucosal reparative response in rat DSS colitis by mesenchymal stem cell therapy2010
Author(s)
Tanaka H, Arimura Y, Yabana T, Goto A, Hosokawa M, Nagaishi K, Naishiro Y, Yamashita K, Yamamoto H, Murata M, Fujimiya M, Imai K, Shinomura Y
Organizer
4th Korea-Japan IBD Symposium
Place of Presentation
Tokyo
Year and Date
2010-01-23
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