2011 Fiscal Year Final Research Report
What is the mechanism for TLRs to modify the onset and progression of NASH?
| Project/Area Number |
21590825
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKUMOTO Kazuo 山形大学, 医学部, 助教 (00466608)
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| Project Period (FY) |
2009 – 2011
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| Keywords | TLR-2 / TLR-4 / 脂肪性肝炎 / IGFBP-2 / サイトカイン / ノックアウトマウス |
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| Research Abstract |
We investigated the role of TLR-2 and TLR-4 in the onset and progression of nonalcoholic steatohepatitis. Wild type, TLR-2(-/-), and TLR-4(-/-) mice were used and experimental steatohepatitis was induced. TLR-2(-/-) group exacerbated the steatohepatitis and TLR-4(-/-) group completely attenuated it. TLR-2(-/-) group decreased the expression of IGFBP-2 and increased the expression of pro-inflammatory cytokines in the liver. Opposite results were observed in TLR-4(-/-) group. Here we showed that TLR-2 attenuated steatohepatitis and TLR-4 exacerbated it by differential expression of various kinds of cytokines.
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Research Products
(13 results)
