2011 Fiscal Year Final Research Report
Importance of NK cells and intrahepatic immune responses for the acceleration of hepatitis C after liver transplantation
| Project/Area Number |
21590834
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAMURA Masaaki 新潟大学, 医歯学総合病院, 医員 (20422602)
MATSUDA Yasunobu 新潟大学, 医歯学系, 准教授 (40334669)
SATO Yoshinobu 新潟大学, 医歯学系, 講師 (20313538)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 肝臓学 |
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| Research Abstract |
The activating receptor natural killer group 2, member D(NKG2D) and its ligands play a crucial role in immune response to infections and tumors. Among the human NKG2D ligands, ULBP1 is prevalently expressed in hepatocellular carcinoma(HCC), but loss of its expression correlates with tumor progression and early recurrence. Although we could not find any significant changes in the gene expression profiles among the recurrent hepatitis C patients and chronic hepatitis C patients yet, our results suggest that the status of intrahepatic NK cell subsets and NK cell receptor ligand expressions might be associated with the rapid progression of recurrent hepatitis C infection.
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Research Products
(19 results)
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[Journal Article] Reduced NKG2D ligand expression in hepatocellular carcinoma correlates with early recurrence2012
Author(s)
Kamimura H, Yamagiwa S, Tsuchiya A, Takamura M, Matsuda Y, Ohkoshi S, Inoue M, Wakai T, Shirai Y, Nomoto M, Aoyagi Y
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Journal Title
J. Hepatol
Volume: 56(2)
Pages: 381-8
Peer Reviewed
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[Journal Article] Failure to achieve 2-log10 viral decrease in first four weeks of peg-IFNalpha-2b plus ribavirin therapy for chronic hepatitis C with genotype 1b and high viral titer is useful in predicting non-response : evaluation of response-guided therapy2011
Author(s)
Ohkoshi S, Yamagiwa S, Yano M, Takahashi H, Aoki YH, Waguri N, Igarashi K, Sugitani S, Takahashi T, Ishikawa T, Kamimura T, Wakabayashi H, Watanabe T, Matsuda Y, Aoyagi Y
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Journal Title
Hepatogastroenterology
Volume: 58(107-108)
Pages: 965-70
Peer Reviewed
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[Journal Article] Characterization of elevated alanine aminotransferase levels during pegylated-interferonα-2b plus ribavirin treatment for chronic hepatitis C2011
Author(s)
Aoki YH, Ohkoshi S, Yamagiwa S, Yano M, Takahashi H, Waguri N, Igarashi K, Sugitani S, Takahashi T, Ishikawa T, Kamimura T, Wakabayashi H, Watanabe T, Matsuda Y, Nomoto M, Aoyagi Y
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Journal Title
Hepatol. Res
Volume: 41(2)
Pages: 118-25
Peer Reviewed
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[Journal Article] Multicentric occurrence of hepatocellular carcinoma with nonalcoholic steatohepatitis2011
Author(s)
Kawai H, Nomoto M, Suda T, Kamimura K, Tsuchiya A, Tamura Y, Yano M, Takamura M, Igarashi M, Wakai T, Yamagiwa S, Matsuda Y, Ohkoshi S, Kurosaki I, Shirai Y, Okada M, Aoyagi Y
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Journal Title
World J. Hepatol
Volume: 3(1)
Pages: 15-23
Peer Reviewed
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[Journal Article] Shear wave velocity is a useful marker for managing nonalcoholic steatohepatitis2010
Author(s)
Osaki A, Kubota T, Suda T, Igarashi M, Nagasaki K, Tsuchiya A, Yano M, Tamura Y, Takamura M, Kawai H, Yamagiwa S, Kikuchi T, Nomoto M, Aoyagi Y
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Journal Title
World J. Gastroenterol
Volume: 16(23)
Pages: 2918-25
Peer Reviewed
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[Journal Article] Loss of liver-intestine cadherin in human intrahepatic cholangiocarcinoma promotes angiogenesis by up-regulating metal-responsive transcription factor-1 and placental growth factor2010
Author(s)
Takamura M, Yamagiwa S, Wakai T, Tamura Y, Kamimura H, Kato T, Tsuchiya A, Matsuda Y, Shirai Y, Ichida T, Ajioka Y, Aoyagi Y
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Journal Title
Int. J. Oncol
Volume: 36(1)
Pages: 245-54
Peer Reviewed
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