2011 Fiscal Year Final Research Report
A study on the anti-cholestatic effect of phenyibutyrate
| Project/Area Number |
21590861
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 胆汁酸 / 胆汁うっ滞 / トランスポーター / 胆汁流量 |
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| Research Abstract |
Biliary transport maximum of taurocholate, a substrate of bile salt export pump was increased by 4-phenylbutyrate in rats, suggesting further increase of the amount of bile salt export pump at the canalicular membrane. In contrast, biliary transport maximum of sulfobromophthalein, a substrate of multidrug resistance protein 2 was not increased by 4-phenylbutyrate. Bile flow and biliary taurocholate excretion inhibited by lipopolysaccharide was relieved by 4-phenylbutyrate. These data suggest that 4-phenylbutyrate is effective in the treatment of intrahepatic cholestasis.
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[Journal Article] Favorable effect of 4-phenylacetate on liver functions attributable to enhanced bile salt export pump expression in ornithine transcarbamylase-deficient children2010
Author(s)
Nagasaka H, Yorifuji T, Kobayashi K, Takikawa H, Komatsu H, Inui A, Fujisawa T, Miida T, Tsukahara H, Takatani T, Hayashi H
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Journal Title
Mol Gen Metab
Volume: 100
Pages: 123-128
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