2011 Fiscal Year Final Research Report
Clinical significance of HCV core region, to antiviral therapy and clinicopatological features.
| Project/Area Number |
21590866
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Okinaka Memorial Institute for Medical Research |
|---|
Principal Investigator |
AKUTA Norio 財団法人冲中記念成人病研究所, 研究員 (20469638)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 肝臓学 |
|---|
| Research Abstract |
Clinical significance of HCV core region, to antiviral therapy and clinicopatological features, was investigated. Substitutions of amino acid 70 and 91 of HCV genotype 1b could predict the response to peginterferon/ribavirin combination therapy and new therapy with Telaprevir. Furthermore, those also affected clinical outcome, including hepatocarcinogenesis, glucose metabolism, and lipid metabolism.
|
Research Products
(18 results)
