The development of novel diagnostic and therapeutic approaches aiming at avoidance of severe hypoglycemia in pancreatic diabetes

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590869
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Hirosaki University
• Principal Investigator: TANDO Yusuke 弘前大学, 医学部・附属病院, 講師 (00332495)
• Co-Investigator(Kenkyū-buntansha): YANAGIMACHI Miyuki 弘前大学, 大学院・医学研究科, 助教 (70372282)
• Project Period (FY): 2009 – 2011
• Keywords: 膵性糖尿病 / 重症低血糖 / 持続血糖モニタリング / インスリン / 膵消化酵素

Research Abstract

In order to establish novel diagnostic and therapeutic approaches aiming at avoidance of severe hypoglycemia in pancreatic diabetes, we studied daily glycemic profiles using the continuous glucose monitoring system, measured plasma levels of adiponectin, insuin and C-peptide and analyzed relevant factors in glycemic control and diabetic complications. The mean glucose concentration, the standard deviation in blood glucose values and the slope of glycemic variability per 5 minutes calculated based on the data from CGMS were predictive factors of hypoglycemia. Furthermore, increased insulin dose and the shortage of pancreatic enzyme supplementation as well as drinking alcohol were associated with a high incidence of hypoglycemia. Abstinence from alcohol and careful insulin treatment with enough digestive enzyme supplements are reconfirmed as one of the appropriate approaches to prevent severe hypoglycemia in pancreatic diabetes.

Research Products

• [Journal Article] Analysis of glycemic variability and in sulin resistance in patients with pancreatic diabetes using a continuous glucose monitoring system (2012)
  • Author(s): Kon A, Tando Y, Yanagimachi M, Tanaka H, Matsuhashi Y, Matsumoto A, Sato E, Chikazwa S, Suda T, Nakamura T
  • Journal Title: Hirosaki Med J
  • Peer Reviewed
• [Journal Article] 膵切除後の合併症とその対策-特に晩期合併症の膵内外分泌障害について (2010)
  • Author(s): 丹藤雄介、今昭人、松橋有紀、中村光男
  • Journal Title: 成人病と生活習慣病 Volume: 40 Pages: 105-109
• [Journal Article] 高齢膵機能不全患者の栄養管理と血糖コントロール (2009)
  • Author(s): 丹藤雄介、柳町幸、今昭人、近澤真司、松橋有紀、柳町幸、佐藤江里、松本敦史、田中光、中村光男
  • Journal Title: 老年消化器病 Volume: 21 Pages: 159-164
• [Presentation] 膵性糖尿病患者の高分子アディポネクチン濃度評価 (2012)
  • Author(s): 今昭人、丹藤雄介、柳町幸、佐藤江里、近澤真司、中村光男、須田俊宏
  • Organizer: 第55回日本糖尿病学会年次学術集会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2012-05-18
• [Presentation] 病態から見たCGMによる血糖変動解析 (2011)
  • Author(s): 今昭人、丹藤雄介、柳町幸、中村光男、他
  • Organizer: 第11回日本先進糖尿病治療研究会
  • Place of Presentation: いわて県民情報交流センター(盛岡市)
  • Year and Date: 2011-11-19
• [Presentation] 膵癌術後膵性糖尿病のCGMによる血糖変動解析 (2011)
  • Author(s): 今昭人、丹藤雄介、柳町幸、中村光男、他
  • Organizer: 第42回日本膵臓学会
  • Place of Presentation: ホテルニューキャッスル(弘前市)
  • Year and Date: 2011-07-29
• [Presentation] CGMによる2型糖尿病患者のインスリン抵抗性評価の試み (2011)
  • Author(s): 今昭人、丹藤雄介、柳町幸、中村光男、他
  • Organizer: 第54回日本糖尿病学会
  • Place of Presentation: 札幌市教育文化会館(札幌市)
  • Year and Date: 2011-05-19
• [Presentation] Does stopping drinking alcohol even after the onset of overt exocrine and endocrine pancreatic insufficiency improve the prognosis of patients with alcohol-induced chronic pancreatitis? (2010)
  • Author(s): Tando Y, Yanagimachi M, Matsuhashi Y, Tanaka H, Sato E, Matsumoto A, Chikazawa S, Kon A, Suda T, Nakamaura T
  • Organizer: The 41th Annual Meeting of the American Pancreatic Association
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2010-11-02
• [Presentation] Glycemic characteristics in continuously monitored patients with pancreatic diabetes treating with pancreatic enzyme replacement therapy (2010)
  • Author(s): Tando Y, Yanagimachi M, Matsuhashi Y, Tanaka H, Sato E, Matsumoto A, Chikazawa S, Kon A, Suda T, Nakamaura T
  • Organizer: Pancreas Fest 2010
  • Place of Presentation: Pittsburgh (USA)
  • Year and Date: 2010-07-29
• [Presentation] Nutritional management and diabetes control in older people with pancreatic insufficiency (2010)
  • Author(s): Tando Y, Kon A, Chikazawa S, Matsuhashi Y, Yanagimachi M, Sato E, Matsumoto A, Tanaka H, Hasegawa N, Nakamura T, Suda T
  • Organizer: Joint Meeting of the International Association of Pancrea-tology and the Japan Pancreas Society
  • Place of Presentation: Fukuoka (Japan)
  • Year and Date: 2010-06-12
• [Presentation] CGM連続血糖モニタリングで絶食輸液中の血糖管理を施行した膵性糖尿病の一例 (2009)
  • Author(s): 丹藤雄介、柳町幸、中村光男、他
  • Organizer: 第24回東北静脈経腸栄養研究会
  • Place of Presentation: 水産ビル(青森市)
  • Year and Date: 2009-12-04
• [Book] KARGER (2011)
  • Author(s): Tando Y, Matsumoto A, Matsuhashi Y, Tanaka H, Yanagimachi M, Nakamura T
  • Total Pages: 112-118
  • Publisher: Gas Biology Research in Clinical Practice