2011 Fiscal Year Final Research Report
Clarification of the molecular mechanism in the defect of pancreatic exocytosis in IRF2^<-/->mice-Searching for a new target of the treatment of acute pancreatitis
| Project/Area Number |
21590872
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Akita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHNISHI Hirohide 秋田大学, 大学院・医学系研究科, 教授 (00313023)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 胆道学 / 膵臓学 |
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| Research Abstract |
The alteration in the pancreas of IRF2 knock-out mice resulted from the defect of regulated exocytosis. Zymogen granules accumulated throughout the cytoplasm and mild acute pancreatitis was proceeding in the acinar cells of Irf2^<-/-> pancreas. However, IRF2 did not regulate the SNARE proteins directly, which plays a pivotal role in the dock and fusion between zymogen granules and apical plasma membrane. So, it is urgently needed to clarify the target gene of IRF2 and molecular mechanisms regulating the pancreatic exocytosis.
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