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2012 Fiscal Year Final Research Report

Quantitative analysis of microvascular architecture as visualized by magnifying endoscopy and development computer-aided diagnosis system

Research Project

  • PDF
Project/Area Number 21590882
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionFukuoka University

Principal Investigator

YAO Kenshi  福岡大学, 医学部, 准教授 (90289546)

Co-Investigator(Renkei-kenkyūsha) IWASHITA Akinori  福岡大学, 医学部, 教授 (70117068)
Project Period (FY) 2009 – 2012
Keywords上部消化管学(食道、胃、十二指腸)
Research Abstract

We developed objective endoscopic diagnostic system based on microvascular architecture as visualized by magnifying endoscopy with narrow-band imaging. We developed program for extraction of microvascular architecture by image analysis. We conducted multicenter prospective study in order to test validity of the method and then we showed that the diagnostic performance is excellent using the magnifying endoscopy. Furthermore, we found phenomenon that gastric epithelial neoplasia acquired function of lipid absorption during this study. And then, we applied this phenomenon and we developed novel endoscopic diagnosis method which enables endoscopist to detect an early gastric cancer efficiently.

  • Research Products

    (18 results)

All 2012 2011 2010 2009

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (5 results) Book (4 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results)

  • [Journal Article] Magnifying endoscopy with narrow-band imaging is useful in the differential diagnosis between low-grade adenoma and early cancer of superficial elevated gastric lesions.2012

    • Author(s)
      Maki S, Yao K, Nagahama T, Beppu T, Hisabe T, Takaki Y, Hirai F, Matsui T, Tanabe H, Iwashita A
    • Journal Title

      Gastric Cancer

    • DOI

      DOI:10.1007/s10120-012-0160-7

    • Peer Reviewed
  • [Journal Article] Nature of white opaque substance in gastric epithelial neoplasia as visualized by magnifying endoscopy with narrow-band imaging.2012

    • Author(s)
      Yao K, Iwashita A, Nambu M, Tanabe H, Nagahama T, Maki S, Ishikawa H,Matsui T, Enjoji M
    • Journal Title

      Dig Endosc

      Volume: 24 Pages: 419-425

    • DOI

      DOI:10.1111/j.1443-1661.2012.01314.x

    • Peer Reviewed
  • [Journal Article] Usefulness of magnifying narrow-band imaging endoscopy for the diagnosis of gastric and colorectal lesions.2012

    • Author(s)
      Hirata I, Nakagawa Y, Ohkubo M, Yahagi N, Yao K
    • Journal Title

      Digestion

      Volume: 85 Pages: 74-79

    • DOI

      DOI:10.1159/000334642.

    • Peer Reviewed
  • [Journal Article] How is the VS (vessel plus surface) classification system applicable to magnifying narrow-band imaging examinations of gastric neoplasias initially diagnosed as low-grade adenomas2012

    • Author(s)
      Yao K
    • Journal Title

      Gastric Cancer

      Volume: 15 Pages: 118-120

    • Peer Reviewed
  • [Journal Article] Usefulness of magnifying endoscopy with narrow-band imaging for determining the horizontal extent of early gastric cancer when there is an unclear margin bychromoendoscopy (with video).2011

    • Author(s)
      Nagahama T, Yao K, Maki S, Yasaka M, Takaki Y, Matsui T, Tanabe H,Iwashita A, Ota A
    • Journal Title

      Gastointest Endosc

      Volume: 74(6) Pages: 1259-1267

    • Peer Reviewed
  • [Journal Article] Magnifying narrowband imaging is more accurate than conventional white-light imaging in diagnosis of gastric mucosal cancer.2011

    • Author(s)
      Ezoe Y, Muto M, Uedo N, Doyama H, Yao K, Oda I, Kaneko K, Kawahara Y, Yokoi C, Sugiura Y, Ishikawa H, Takeuchi Y, Kaneko Y, Saito Y
    • Journal Title

      Gastroenterology

      Volume: 141 Pages: 2017-2025

    • DOI

      DOI:10.1053/j.gastro.2011.08.007.

    • Peer Reviewed
  • [Journal Article] Magnifying endoscopy for diagnosing and delineating early gastric cancer2009

    • Author(s)
      Yao K
    • Journal Title

      Anagnostopoulos G, Ragunath K Endoscopy

      Volume: 41 Pages: 462-467

    • DOI

      DOI:10.1055/s-0029-1214594.

    • Peer Reviewed
  • [Presentation] Improving detection of early gstric mucosal lesions: What can we learn from our Japanese colleages2011

    • Author(s)
      Yao K
    • Organizer
      UEGW 2011
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      20111022-1026
  • [Presentation] Novel clinical application of magnifying endoscopy (ME) with narrow-band imaging (NBI): Observation of fat absorption by neoplasia within the stomach.2011

    • Author(s)
      Yao K
    • Organizer
      DDW 2011
    • Place of Presentation
      Chicago, the USA
    • Year and Date
      20110507-0510
  • [Presentation] Advantage of magnifying endoscopy (ME) with narrow-band imaging(NBI) over standard endoscopy for determining the margins of lateral extent of early gastric cancer.2010

    • Author(s)
      Nagahama T
    • Organizer
      18th United European Gastroenterology Week
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      20101023-1027
  • [Presentation] The nature of white opaque substance (WOS) as visualized by magnifying endoscopy within the stomach.2010

    • Author(s)
      Yao K
    • Organizer
      18th United European GastroenterologyWeek
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      20101023-1027
  • [Presentation] New frontiers of endoscopy in gastric cancer:diagnosis focusing on detection of intra-mucosal spreading by magnifying endoscopy (ME) with narrow-band imaging (NBI).2009

    • Author(s)
      Yao K
    • Organizer
      8th International gastric cancer conference
    • Place of Presentation
      Poland
    • Year and Date
      2009-06-11
  • [Book] Zoom gastroscopy: magnifying endoscopy in the stomach (韓国語版)2012

    • Author(s)
      Yao K
    • Total Pages
      240
    • Publisher
      Koonja Publishing Co Seoul
  • [Book] 動画で学ぶ医拡大内視鏡テクニック2012

    • Author(s)
      八尾建史
    • Total Pages
      54
    • Publisher
      日本メディカルセンター
  • [Book] NBI内視鏡アトラス2011

    • Author(s)
      武藤学、八尾建史、佐野寧
    • Total Pages
      14-18、112-192
    • Publisher
      南江堂
  • [Book] 胃拡大内視鏡2009

    • Author(s)
      八尾建史
    • Total Pages
      230
    • Publisher
      日本メディカルセンター
  • [Patent(Industrial Property Rights)] 胃上皮性腫瘍(腺腫・胃癌)の診断に 有用な白色不透明物質を応用した内視鏡観 察法および診断能改善組成物2011

    • Inventor(s)
      八尾建史
    • Industrial Property Rights Holder
      学校法人福岡大学
    • Industrial Property Number
      特許,PCT/JP2011/071389 (PCT 国際出願)
    • Filing Date
      2011-09-20
    • Overseas
  • [Patent(Industrial Property Rights)] (米国仮出願)NATURE OF WHITE OPAQUE SUBSTANCE (WOS) AS VISUALIZED BY MAGNIFYING ENDOSCOPY WITHIN THE STOMACH]2010

    • Inventor(s)
      八尾建史
    • Industrial Property Rights Holder
      学校法人福岡大学
    • Industrial Property Number
      特許,US 61/405,962 (米国仮出願)
    • Filing Date
      2010-10-22
    • Overseas

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Published: 2014-08-29  

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