2011 Fiscal Year Final Research Report
Modification of Cardiovascular Remodeling via Heat Shock Protein and Repair of Oxidative DNA damage
| Project/Area Number |
21590883
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 血管リモデリング / 塩基除去修復 / AP endonuclease / 血管傷害モデル / 酸化ストレス / HSP72 / 温熱刺激 / 血管炎症 |
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| Research Abstract |
DNA damage is one of the major cause of atherosclerotic cardiovascular diseases. We focused on Ape 1, themajor enzyme of base excision repair system. Ape 1 was highly expressed in a damaged cardiovascular lesion, and the transfection of Ape 1 gene effectively prevented cardiovascular remodeling. Thermal treatment at 41 degree Celsius induced heat shock protein (HSP) 72 expression, and reduced oxidative stress. Ape1 and HSP 72 additively show an antiatherosclerotic action and are a potential new strategy for suppression of cardiovascular remodeling.
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