The new biomarker to diagnose heart failure

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590886
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Chiba University
• Principal Investigator: HASEGAWA Hiroshi 千葉大学, 大学院・医学研究院, 助教 (50375656)
• Project Period (FY): 2009 – 2011
• Keywords: 心不全 / 虚血性心疾患 / 心腎連関 / 左室リモデリング

Research Abstract

To evaluate the factors to detect the prognosis of the patients with heart failure, blood samples, clinical factors and medicine were screened. The anti-p53 antibody was not related to the severity of the heart failure. The prescription of telmisartan was related to the inhibitory effects on the progression of intima-media thickness of the carotid artery wall. The prescription of candesartan was related to the inhibitory effects on the morning hypertension, which was one of the risk factors of cardiovascular mortality.

Research Products

• [Journal Article] Effects of Pitavastatin on Pressure Overload-Induced Heart Failure in Mice (2012)
  • Author(s): Kameda Y, Hasegawa H, Kubota A, Tadokoro H, Kobayashi Y, Komuro I, Takano H
  • Journal Title: Circ J Volume: 76 Pages: 1159-1168
• [Journal Article] Role of regulatory T cells in atheroprotective effects of granulocyte colony-stimulating factor (2012)
  • Author(s): Uchiyama R, Hasegawa H, Kameda Y, Ueda K, Kobayashi Y, Komuro I, Takano H
  • Journal Title: J Mol Cell Cardiol Volume: 52 Pages: 1038-1047
• [Journal Article] Effect of Switching from Telmisartan, Valsartan, Olmesartan, or Losartan to Candesartan on Morning Hypertension (2012)
  • Author(s): Hasegawa H, Takano H, Kameda Y, Kubota A, Kobayashi Y, Komuro I
  • Journal Title: Clin Exp Hypertens Volume: 34 Pages: 86-91
• [Journal Article] 高野博之PPAR (2012)
  • Author(s): 長谷川洋
  • Journal Title: 血管医学 Volume: (in press)
• [Journal Article] Effects of valsartan and amlodipine on home blood pressure and cardiovascular events in Japanese hypertensive patients : a subanalysis of the VART (2011)
  • Author(s): Takano H, Hasegawa H, Narumi H, Shindo S, Mizuma H, Kuwabara Y, Kobayashi Y, Komuro I
  • Journal Title: J Hum Hypertens Pages: 1-8
• [Journal Article] Therapeutic Implications of PPARgamma in Cardiovascular Diseases (2010)
  • Author(s): Hasegawa H, Takano H, Komuro I
  • Journal Title: PPAR Res 2010
• [Journal Article] Sonic hedgehog is a critical mediator of erythropoietin-induced cardiac protection in mice (2010)
  • Author(s): Ueda K, Takano H, Niitsuma Y, Hasegawa H, Uchiyama R, Oka T, Miyazaki M, Nakaya H, Komuro I
  • Journal Title: J Clin Invest Volume: 120 Pages: 2016-2029
• [Journal Article] 心不全の新しい発生機序と再生治療 (2010)
  • Author(s): 長谷川洋, 小室一成
  • Journal Title: 日本臨牀内科医会会誌 Volume: 24 Pages: 628-634
• [Journal Article] 細胞老化と炎症 (2010)
  • Author(s): 長谷川洋, 南野徹
  • Journal Title: 血管医学 Volume: 12 Pages: 31-39
• [Journal Article] 高血圧性,弁膜症性心不全 (2009)
  • Author(s): 長谷川洋, 小室一成
  • Journal Title: 医学のあゆみ Volume: 232 Pages: 309-315
• [Journal Article] 拡張障害型心不全 (2009)
  • Author(s): 長谷川洋, 小室一成
  • Journal Title: Medical Practice Volume: 26 Pages: 1924-1929
• [Presentation] Effect of Pitavastatin on Pressure (2012)
  • Author(s): Yoshihito Kameda, Hiroshi Hasegawa, Akihiko Kubota, Hiroyuki Tadokoro, Yoshio Kobayashi, Hiroyuki Takano
  • Organizer: Overload-Induced Heart Failure in Mice American College of Cardiology 2012
  • Place of Presentation: 米国シカゴ
  • Year and Date: 2012-03-26
• [Presentation] The roles of regulatory T cells in the atheroprotective effects of granulocyte colony-stimulating factor (2012)
  • Author(s): 久保田暁彦, 長谷川洋
  • Organizer: 日本循環器学会総会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2012-03-16
• [Presentation] Role of Regulatory T Cells in Atheroprotective Effects of Granulocyte Colony-Stimulating Factor (2011)
  • Author(s): Hiroshi Hasegawa, Hiroyuki Takano, Raita Uchiyama, Kazutaka Ueda, Yoshihito Kameda,Yoshio Kobayashi,Issei Komuro
  • Organizer: American Heart Association 2011
  • Place of Presentation: 米国オーランド
  • Year and Date: 2011-11-15
• [Presentation] バルサルタンおよびアムロジンの家庭血圧および心血管イベントに対する効果の検討 (VARTサブ解析) (2011)
  • Author(s): 長谷川洋
  • Organizer: 第34回日本高血圧学会総会
  • Place of Presentation: 栃木県総合文化センター
  • Year and Date: 2011-10-20
• [Presentation] Effects of telmisartan and losartan on cardiovascular protection in Japanese hypertensive patients -TALENT study- (2011)
  • Author(s): 長谷川洋
  • Organizer: 日本心臓病学会総会
  • Place of Presentation: 神戸ポートピア ホテル
  • Year and Date: 2011-09-25
• [Presentation] Effects of valsartan and amlodipine on home blood pressure and cardiovascular events in Japanese hypertensive patients (2011)
  • Author(s): H. Hasegawa, H. Takano, H. Narumi, S. Shindo, H. Mizuma, Y. Kuwabara, Y. Kobayashi, I. Komuro
  • Organizer: a subanalysis of the VART European Society of Cardiology 2011
  • Place of Presentation: パリ フランス
  • Year and Date: 2011-08-30
• [Presentation] テルミサルタンとロサルタンの心血管リモデリングに対する効果の比較-TALENT試験- (2010)
  • Author(s): 長谷川洋, et al
  • Organizer: 第33回日本高血圧学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-15
• [Presentation] Effects of telmisartan and losartran on cardiovascular remodeling in Japanese hypertensive patients (2010)
  • Author(s): Hiroshi Hasegawa, et al
  • Organizer: Euroean Society of Cardiology
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2010-08-31
• [Presentation] G-CSF therapy for acute myocardial infarction : Studies of animal experiments give valuable hints to clinical trials. (2009)
  • Author(s): Hiroshi Hasegawa, Hiroyuki Takano, Issei Komuro
  • Organizer: The 26th Annual Meetingof ISHR Japanese Section
  • Place of Presentation: 北海道大学,札幌
  • Year and Date: 2009-12-05
• [Book] 拡張型心筋症循環器疾患最新の治療2010-2011 (2010)
  • Author(s): 長谷川洋, 小室一成
  • Total Pages: 567
  • Publisher: 南江堂