2011 Fiscal Year Final Research Report
Arrhythmogenic substrate and therapeutic interventions of Tdp induced by class III and IV antiarrhythmic drugs(Tridimentional mapping of the heart)
| Project/Area Number |
21590890
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
FURUSHIMA Hiroshi 新潟大学, 医歯学総合病院, 助手 (10377161)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | III群 / IV群抗不整脈薬 / 心臓立体マッピング |
|---|
| Research Abstract |
A high correlation was found between surface ECG Tp-e(from peak to end interval of T wave) and total left ventricular dispersion. In contrast, pseudo transmural Tp-e correlated with transmural recovery time(RT) dispersion. The shortest RT in the heart roughly corresponded to the peak, as did the longest RT with the end of the T wave on the surface ECG. Pacing treatment was most effective in anthopleurin-A model followed by E-4031, bepridil and amiodarone model. On the other hand, supplemental treatment of potassium showed the greatest therapeutic effect in E-4031 model. Magnesium homogenized the distribution of ventricular repolarization in anthopleurin-A model but not in the other models created by E-4031, bepridil and amiodarone.
|
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Non-linear radiofrequency catheter ablation for electrical storm due to non-ischemic ventricular tachycardia2011
Author(s)
Chinushi M, Iijima K, Izumi D, Furushima H, Sato A, Hosaka Y, Hasegawa K, Yagihara N, Watanabe H, Sanada A, Aizawa Y.
Organizer
The 75th annual scientific meeting of the Japanese Circulation Society
Place of Presentation
Yokohama
Year and Date
20110803-04
-
-
-
-
-
-
-
