2011 Fiscal Year Final Research Report

The role of salt sensitivity in the development of heart failure with preserved ejection fraction and the relation of intrinsic steroids

Research Project

Project/Area Number	21590893
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Circulatory organs internal medicine
Research Institution	Osaka University
Principal Investigator	SAKATA Yasushi 大阪大学, 医学系・研究科, 講師 (00397671)
Co-Investigator(Kenkyū-buntansha)	YAMAMOTO Kazuhiro 鳥取大学, 医学部, 教授 (90303966) MANO Toshiaki 大阪大学, 医学部附属病院, 講師 (90379165)
Project Period (FY)	2009 – 2011
Keywords	心不全 / 拡張機能 / 食塩感受性
Research Abstract	The production of CTS was enhanced in hypertensive HFPEF model. Ouabain activated p42/ 44 MAPKs and enhanced collagen production through the elevation of cytosolic Ca^<2+> concentration via NCX entry mode. SEA0400, the potent inhibitor of NCX entry mode, prevented the development of LV fibrosis and stiffening and the transition to HFPEF with the improvement of survival rate in the animal models. Thus, CTS and the subsequently activated Ca^<2+> entry mode of NCX may play an important role in the development of LV fibrosis and hypertensive HFPEF, and the blockade of the entry mode of NCX is likely a new therapeutic strategy for this phenotype of heart failure.