2011 Fiscal Year Final Research Report
Effect of Angiotensin II Type I Receptor Gene Polymorphism on Cardiac Events in Patients with Hypertension
| Project/Area Number |
21590894
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kwansei Gakuin University (2010-2011)
Osaka University (2009) |
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Principal Investigator |
SATO Hiroshi 関西学院大学, 人間福祉学部, 教授 (10294092)
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| Co-Investigator(Kenkyū-buntansha) |
SAKATA Yasuhiko 大阪大学, 大学院・医学系研究科, 助教 (90379206)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 臨床心血管病態学 |
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| Research Abstract |
Clinical impact of polymorphism of angiotensin receptor gene(AT1R(1166A→C)) was examined in discharged patients with acute myocardial infarction. This polymorphism related with increased risk for cardiac death especially in patients with hypertension. Furthermore, MicroRNA155, which reduces translation of ATIR, was elevated in patients with cardiac death early after discharge.
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[Journal Article] Oral treatment with nicorandil at discharge is associated with reduced mortality after acute myocardial infarction2012
Author(s)
Sakata Y, Nakatani D, Shimizu M, Suna S, Usami M, Matsumoto S, Hara M, Sumitsuji S, Kawano S, Iwakura K, Hamasaki T, Sato H, Nanto S, Hori M, Komuro I
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Journal Title
J Cardiol
Volume: 59
Pages: 14-21
Peer Reviewed
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[Journal Article] SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population2011
Author(s)
Aoki A, Ozaki K, Sato H, Takahashi A, Kubo M, Sakata Y, Onouchi Y, Kawaguchi T, Lin TH, Takano H, Yasutake M, Hsu PC, Ikegawa S, Kamatani N, Tsunoda T, Juo SH, Hori M, Komuro I, Mizuno K, Nakamura Y, Tanaka T
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Journal Title
J Hum Genet
Volume: 56(1)
Pages: 47-51
Peer Reviewed
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[Journal Article] SNPs in BRAP associated with risk of myocardial infarction in Asian populations2009
Author(s)
Ozaki K, Sato H, Inoue K, Tsunoda T, Sakata Y, Mizuno H, Lin TH, Miyamoto Y, Aoki A, Onouchi Y, Sheu SH, Ikegawa S, Odashiro K, Nobuyoshi M, Juo SH, Hori M, Nakamura Y, Tanaka T
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Journal Title
Nat Genet
Volume: 41(3)
Pages: 329-33
Peer Reviewed
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[Journal Article] Impact of Diabetes Mellitus on Rehospitalization for Heart Failure Among Survivors of Acute Myocardial Infarction in the Percutaneous Coronary Intervention Era2009
Author(s)
Nakatani D, Sakata Y, Mizuno H, Shimizu M, Suna S, Usami M, Ito H, Yasumura Y, Hirayama A, Takeda H, Hori M and Sato H
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Journal Title
Circ J
Volume: 73(4)
Pages: 662-666
Peer Reviewed
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[Presentation] Circulating microRNAs may Predict Future Cardiac Remodeling and Heart Failure in Patients after Acute Myocardial Infarction2012
Author(s)
Yasuhiko Sakata, Sen Matsumoto, Daisaku Nakatani, Sinichiro Suna, Masaya Usami, Masahiko Hara, Takayuki Kojima, Hiroshi Sato, Masatake Fukunami, Shinsuke Nanto, Masatsugu Hori, and Issei Komuro
Organizer
第76回日本循環器学会総会
Place of Presentation
Fukuoka. Japan
Year and Date
2012-03-17
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