2011 Fiscal Year Final Research Report
Development of diagnostic methods to detect unstable atherosclerotic plaques with combination of clinical and basic research.
| Project/Area Number |
21590895
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kobe University |
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Principal Investigator |
SHITE Junya 神戸大学, 医学部附属病院, 准教授 (40362793)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Tomoya 神戸大学, 大学院・医学研究科, 助教 (90437468)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 動脈硬化 / 虚血性心疾患 |
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| Research Abstract |
We investigated the diagnostic and therapeutic methods for atherosclerotic plaque rapture in clinics. We had already reported the observational research results ; coronary arterial lesions and thrombus following sirolimus-eluting stent implantation assessed by optical coherence tomography, Effect of some drugs on the stability of coronary atherosclerotic plaques. Moreover, we developed some of the new anti-inflammatory therapies against atherosclerosis in basic experiments using mouse. We united the clinical and basical research results and discovered the drug's beneficial mechanism that the drug regressed atherosclerotic lesions or stabilized the lesions in clinical research. We could not discover the new marker for predicting the atherosclerotic plaque rapture, so far.
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