2011 Fiscal Year Final Research Report
Serial changes in platelet activation biomarkers and the effects of anti-platelet therapy in percutaneous coronary intervention
Project/Area Number |
21590903
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
|
Research Institution | Kumamoto University |
Principal Investigator |
KAIKITA Koichi 熊本大学, 医学部附属病院, 講師 (30346978)
|
Research Collaborator |
ONO Takamichi 熊本大学, 医学教育部, 学生
|
Project Period (FY) |
2009 – 2011
|
Keywords | 循環器・高血圧 / 遺伝子 |
Research Abstract |
We investigated the effects of CYP2C19 gene variants on platelet function tests and biomarkers of coagulation activation and inflammation in patients undergoing elective percutaneous coronary intervention(PCI). Only on-clopidogrel residual platelet aggregation was associated with the CYP2C19-reduced function allele in patients treated with clopidgrel. These platelet function tests may be useful for identifying carriers of CYP2C19 reduced-function gene variants and monitoring the efficacy of dual antiplatelet therapy in patients undergoing elective PCI.
|
-
[Journal Article] Determination of Cut-off Levels for On-clopidogrel Platelet Aggregation Based on Functional CYP2C19 Gene Variants in Patients Undergoing Elective Percutaneous Coronary Intervention2011
Author(s)
Ono T, Kaikita K, Hokimoto S, Iwashita S, Yamamoto K, Miyazaki Y, Horio E, Sato K, Tsujita K, Abe T, Deguchi M, Tayama S, Sumida H, Sugiyama S, Yamabe H, Nakamura S, Nakagawa K, Ogawa H
-
Journal Title
Thromb Res
Volume: 128
Pages: e130-6
Peer Reviewed
-
-
[Journal Article] Impact of CYP2C19 polymorphism on residual platelet reactivity in patients with coronary heart disease during antiplatelet therapy2010
Author(s)
Yamamoto K, Hokimoto S, Chitose T, Morita K, Ono T, Kaikita K, Tsujita K, Abe T, Deguchi M, Miyagawa H, Saruwatari J, Sumida H, Sugiyama S, Nakagawa K, Ogawa H
-
Journal Title
J Cardiol
Volume: 57
Pages: 194-201
Peer Reviewed
-
-
-
-
[Presentation] Impact of CYP2C19 Polymorphism on Residual Platelet Reactivity in Patients with Coronary Heart Disease during Antiplatelet Therapy2011
Author(s)
Yamamoto K, Hokimoto S, Chitose T, Ono T, Izumiya Y, Tsujita K, Kaikita K, Sumida H, Sugiyama S, Nakagawa K, Ogawa H
Organizer
第75回日本循環器学会総会・学術集会
Place of Presentation
パシフィコ横浜、横浜
Year and Date
20110803-04
-
[Presentation] Besides CYP2C19 Polymorphism, Genetic Variation of CYP3A5 is Associated with Higher Ontreatment Platelet Reactivity in Patients Undergoing Coronary Stenting2011
Author(s)
Yamamoto K, Hokimoto S, Chitose T, Ono T, Izumiya Y, Tsujita K, Tayama S, Kaikita K, Sumida H, Sugiyama S, Nakagawa K, OgawaH
Organizer
第75回日本循環器学会総会・学術集会
Place of Presentation
パシフィコ横浜、横浜
Year and Date
20110803-04
-
[Presentation] Determination of Optimal Cut-Off Value in On-Clopidogrel Platelet Aggregation by VerifyNow P2Y12 System Based on Functional CYP2C19 Gene Variants2011
Author(s)
Ono T, Kaikita K, Sato K, Horio E, Chitose T, Yamamoto K, Tsujita K, Tayama S, Hokimoto S, Sumida H, Sugiyama S, Yamabe H, Morita K, Nakagawa K, Ogawa H
Organizer
第75回日本循環器学会総会・学術集会
Place of Presentation
パシフィコ横浜、横浜
Year and Date
20110803-04
-
-
[Presentation] Optimal Cut-off Levels for On-clopidogrel platelet Aggregation Based on Functional CYP2C19 Gene Variants in Patients Undergoing Elective Percutaneous Coronary Intervention2011
Author(s)
Kaikita K, Ono T, Hokimoto S, Yamamoto K, Tsujita K, Tayama S, Sumida H, Sugiyama S, Nakazawa K, Nakamura S, Ogawa H
Organizer
第20回日本心血管インターベンション治療学会/CVIT2011
Place of Presentation
大阪国際会議場、大阪
Year and Date
20110721-24
-
[Presentation] Determination of Optimal Cut-Off Value in On-Clopidogrel Platelet Aggregation by VerifyNow P2Y12 System Based on Functional CYP2C19 Gene Variants2011
Author(s)
Ono T, Kaikita K, Hokimoto S, Yamamoto K, Miyazaki Y, Sakamoto K, Tsujita K, Iwashita S, Sumida H, Sugiyama S, Yamabe H, Ogawa H
Organizer
American College of Cardiology 2011
Place of Presentation
ニューオーリンズ、米国
Year and Date
20110402-05
-
-
[Presentation] Functional CYP2C19 Gene Variants are Associated With Both On-clopidogrel Platelet Adhesiveness and Aggregation in Japanese Patients With Coronary Artery Disease2010
Author(s)
Kaikita K, Ono T, Hokimoto S, Tsujita K, Miyazaki Y, Sato K, Horio E, Sumida H, Sugiyama S, Ogawa H
Organizer
American Heart Association Scientific Sessions 2010
Place of Presentation
Chicago, Illinois
Year and Date
20101113-17
-