2011 Fiscal Year Final Research Report
Mechanism of Ventricular Fibrillation : Establishment of Novel Technique for Predicting Sudden Cardiac Death
| Project/Area Number |
21590909
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Toho University (2011)
Kyorin University (2009-2010) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAZAWA Kazuo 国立循環器病研究センター, 研究情報基盤管理室, 室長 (50198058)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 臨床心血管病態学 / 不整脈学 / 心電図学 / 心臓突然死 |
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| Research Abstract |
Sudden cardiac death(SCD) remains one of the major challenges of contemporary cardiology. Major clinical trials have demonstrated that primary prophylaxis of implantable cardioverter-defibrillators(ICD) is effective in saving lives. It is well known that SCD is caused by mainly ventricular fibrillation(VF). In this study, we seek to clarify the mechanism of VF and to establish techniques for predicting SCD. At the first year(2009), we assessed electrophysiological indices that are related to the generation of VF with computer simulation using super computer and mapping analysis from animal models. As a result, the generation of VF is more associated with repolarization abnormality than depolarization abnormality. At the second year(2010), we reanalyzed data that obtained at the first year, then, assessed which electrophysiological marker is useful to detect repolarization abnormality. T-wave alternans(TWA), i. e., alternation of T wave on the electrocardiogram appears to be the best marker to detect the abnormality. At the last year, we evaluated clinical utility of TWA and other electrophysiological makers such as late potentials by signal-averaged electrocardiography and heart rate turbulence in some settings(myocardial infarction, cardiomyopathy, etc). Our data support that TWA is the most useful technique to detect patients at risk for SCD.
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Research Products
(45 results)
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[Journal Article] For the PREVENT-SCD Investigators : Prognostic utility of T-wave alternans in a real-world population of patients with left ventricular dysfunction : the PREVENT-SCD study2012
Author(s)
Shizuta S, Ando K, Nobuyoshi M, Ikeda T, Yoshino H, Hiramatsu S, Kazatani Y, Yamashiro K, Okajima K, Kajiya T, Kobayashi Y, Kato T, Fujii S, Mitsudo K, Inoue K, Ito H, Haruna Y, Doi T, Nishio Y, Ozasa N, Nishiyama K, Kita T, Morimoto T, Kimura T
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Journal Title
Clin Res Cardiol
Volume: 101
Pages: 89-99
Peer Reviewed
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[Journal Article] Microvolt T-wave alternans : Physiologic basis, methods of measurement, and clinical utility : Consensus statement by the International Society for Holter and Noninvasive Electrocardiology2011
Author(s)
Verrier, RL, Klingenheben T, Malik M, El-Sherif N, Exner DV, Hohnloser SH, Ikeda T, Martinez JP, Narayan SM, Nieminen T, Rosenbaum DS
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Journal Title
J Am Coll Cardiol
Volume: 58
Pages: 1309-1324
Peer Reviewed
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[Journal Article] Heart rate turbulence can predict cardiac mortality following myocardial infarction in patients with diabetes mellitus2011
Author(s)
Miwa Y, Miyakoshi M, Hoshida K, Yanagisawa R, Abe A, Tsukada T, Ishiguro H, Mera H, Yusu S, Yoshino H, Ikeda T
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Journal Title
J Cardiovasc Electrophysiol
Volume: 22
Pages: 1135-1140
Peer Reviewed
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[Journal Article] Effects of landiolol, an ultra-short-acting β1-selective blocker, on electrical storm refractory to class III antiarrhythmic drugs2010
Author(s)
Miwa Y, Ikeda T, Mera H, Miyakoshi M, Hoshida K, Yanagisawa K, Ishiguro H, Tsukada T, Abe A, Yusu S, Yoshino H
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Journal Title
Circ J
Volume: 74
Pages: 856-863
Peer Reviewed
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