Role of Mitochondria on Platelet Activation Contributing to the Onset of Acute Myocardial Infarction

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590911
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Tokai University
• Principal Investigator: GOTO Shinya 東海大学, 医学部, 教授 (50225653)
• Project Period (FY): 2009 – 2011
• Keywords: 血小板 / ミトコンドリア / 血栓 / アテローム血栓 / 心筋梗塞 / 電子伝達系 / 動脈血栓

Research Abstract

Platelets play crucial role in the onset of acute myocardial infarction. Platelets are active cells in view of energetic metabolism with several mitochondria. This study attempts to clarify the role of mitochondria in platelet cells for the onset of acute myocardial infarction.
Mitochondria need oxygen to express their physiological function. Platelets in arterial blood containing high oxygen concentration have higher thrombogenicity than those in venous blood. The number and localization of mitochondria was not influenced by platelet activation. Cyclic increase in intracellular concentration of calcium ion induced by platelet activation was inhibited when the function of mitochondria was blocked.

Research Products

• [Journal Article] The ATLAS ACS 2.TIMI 51 Investigators. Rivaroxaban in Patients with a Recent Acute Coronary Syndrome (2011)
  • Author(s): Mega JL, Braunwald E, Wiviott SD, Bassand JP, Bhatt DL, Bode C, Burton P, Cohen M, Cook-Bruns N, Fox KA, Goto S, Murphy SA, Plotnikov AN, Schneider D, Sun X, Verheugt FW, Gibson CM
  • Journal Title: N Engl J Med Volume: 366(1) Pages: 9-19
  • Peer Reviewed
• [Journal Article] Apixaban versus Warfarin in Patients with Atrial Fibrillation (2011)
  • Author(s): Granger CB, Alexander JH, McMurray JJ, Lopes RD, Hylek EM, Hanna M, Al-Khalidi HR, Ansell J, Atar D, Avezum A, Bahit MC, Diaz R, Easton JD, Ezekowitz JA, Flaker G, Garcia D, Geraldes M, Gersh BJ, Golitsyn S, Goto S, Hermosillo AG, Hohnloser SH, Horowitz J, Mohan P, Jansky P, Lewis BS, Lopez-Sendon JL, Pais P, Parkhomenko A, Verheugt FW, Zhu J, Wallentin L
  • Journal Title: N Engl J Med Volume: 365 Pages: 981-992
  • Peer Reviewed
• [Journal Article] The J-TRACE Investigators. One-Year Cardiovascular Event Rates in Japanese Outpatients With Myocardial Infarction (2011)
  • Author(s): Goto S, Ikeda Y, Shimada K, Uchiyama S, Origasa H, Kobayashi H
  • Journal Title: Circ J Volume: 75(11) Pages: 2598-2604
  • Peer Reviewed
• [Journal Article] Safety and Tolerability of Atopaxar in the Treatment of Patients With Acute Coronary Syndromes (2011)
  • Author(s): O' Donoghue ML, Bhatt DL, Wiviott SD, Goodman SD, Fitzgerald DJ, Angiolillo DJ, Goto S, Montalescot G, Zeymer U, Aylward PE, Guetta V, Dudek D, Ziecina R, Contant CF, Flather MD
  • Journal Title: Circulation Volume: 123 Pages: 1843-53
  • Peer Reviewed
• [Journal Article] Bhatt DL on behalf of the REACH Registry Investigators (2011)
  • Author(s): Goto S, Ikeda Y, Chan JCN, Wilson PWF, Yeo TC, Liau CS, Abola MT, Salette G, Steg PG, Bhatt DL
  • Journal Title: Heart Asia Volume: 3 Pages: 92-98
  • Peer Reviewed
• [Journal Article] Randomized Trial of Atopaxar in the Treatment of Patients With Coronary Artery Disease (2011)
  • Author(s): Wiviott SD, Flather MD, O' Donoghue ML, Goto S. Fitzgerald DJ, Cura F, Aylward P, Guetta V, Dudek D, Contant CF, Angiolillo DJ, Bhatt DL
  • Journal Title: Circulation Volume: 123 Pages: 1854-63
  • Peer Reviewed
• [Journal Article] Double-blind, placebo-controlled Phase II studies of the PAR-1 antagonist E5555 in Japanese patients with acute coronary syndrome(ACS) or high-risk coronary artery disease(CAD) (2010)
  • Author(s): Goto S, Ogawa H, Takeuchi M, Flather M, Bhatt DL
  • Journal Title: Eur Heart J Volume: 31(21) Pages: 2601-2613
  • Peer Reviewed
• [Journal Article] Disturbed blood flow induces erosive injury to smooth muscle cell-rich neointima and promotes thrombus formation in rabbit femoral artery (2010)
  • Author(s): Sumi, T. Yamashita, A. Matsuda, S. Goto, S. Nishihira, K. Furukoji, E. Sugimura, H. Kawahara, H. Imamura, T. Kitamura, K. Tamura, S. Asada, Y
  • Journal Title: J Thromb Haemost Volume: 8 Pages: 1394-402
  • Peer Reviewed
• [Journal Article] Lnk/Sh2b3 regulates integrin αIIbβ3 outside-in signaling in platelets leading to stabilization of developing thrombus in vivo (2010)
  • Author(s): Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, and Eto K
  • Journal Title: J Clin Invest Volume: 120 Pages: 179-90
  • Peer Reviewed
• [Journal Article] Basic Principles of Platelet Biology and Clinical Implications (2010)
  • Author(s): Angiolillo DJ, Ueno M, and Goto S
  • Journal Title: Circ J Volume: 74 Pages: 597-607
  • Peer Reviewed
• [Journal Article] Platelet thrombin receptor antagonism and atherothrombosis (2010)
  • Author(s): Angiolillo DJ, Capodanno D, and Goto S
  • Journal Title: Eur Heart J Volume: 31(1) Pages: 17-28
  • Peer Reviewed
• [Journal Article] Imaging of Structural Changes in Endothelial Cells and Thrombus Formation at the Site of FeCl3-Induced Injuries in Mice Cremasteric Arteries (2009)
  • Author(s): Kawamura Y, Takahari Y, Tamura N, Eguchi Y, Urano T, Ishida H and Goto S
  • Journal Title: J Atheroscler Thromb Volume: 16(6) Pages: 807-814
  • Peer Reviewed
• [Journal Article] Important regulatory role of activated platelet-derived procoaulant activity in the propagation of thrombi formed under arteiral blood flow conditions (2009)
  • Author(s): Tamura N, Kitajima I, Kawamura Y, Toda E, Eguchi Y, Ishida H, Goto S
  • Journal Title: Circ J Volume: 73 Pages: 540-548
  • Peer Reviewed
• [Journal Article] ADAMTS-13 attenuates thrombus formation on type I collagen surface and disrupted plaques under flow conditions (2009)
  • Author(s): Moriguchi-Goto S, Yamashita A, Tamura N, Soejima K, Takahashi M, Nakagaki T, Goto S, Asada Y
  • Journal Title: Atherosclerosis Volume: 203 Pages: 409-16
  • Peer Reviewed
• [Presentation] 教育講演:ステント後の抗血栓療法 (2011)
  • Author(s): 後藤信哉
  • Organizer: 第59回日本心臓病学会学術集会
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2011-09-23
• [Presentation] Lower Risk of Coronary Events in Japanese Outpatients with Ischemic Stroke-Results from the Effective Vascular Event Reduction after Stroke Registry (2011)
  • Author(s): Goto S
  • Organizer: The 75th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2011-08-03
• [Presentation] ROLE OF MITOCHONDRIA IN THE PROCESS OF PLATELET ACTIVATION AND THROMBUS FORMATION UNDER BLOOD FLOW CONDITIONS (2011)
  • Author(s): Tamura N, and Goto S
  • Organizer: ISTH 2011
  • Place of Presentation: ICC京都(京都市)
  • Year and Date: 2011-07-28
• [Presentation] Risk and benefit of anti-thrombotic therapy : Still ignore the bleeding risk? (2011)
  • Author(s): Goto S
  • Organizer: ISTH 2011
  • Place of Presentation: ICC京都(京都市)
  • Year and Date: 2011-07-25
• [Presentation] 血管内治療における抗血小板薬の役割 (2011)
  • Author(s): 後藤信哉
  • Organizer: 第10回日本頸部脳血管治療学会
  • Place of Presentation: 千里ライフサイエンスセンター(大阪市)
  • Year and Date: 2011-06-11
• [Book] How can we avoid stroke crisis in the Asia-Pacific region? (2011)
  • Author(s): Goto S, et al
  • Total Pages: 1-81
  • Publisher: Chameleon Communications International
• [Book] 抗血栓療法ハンドブック (2011)
  • Author(s): 後藤信哉
  • Total Pages: 1-107
  • Publisher: 中外医学社
• [Book] そこが知りたい抗血栓療法 (2011)
  • Author(s): 後藤信哉
  • Total Pages: 1-255
  • Publisher: Medical View
• [Patent(Industrial Property Rights)] 特許 (2011)
  • Inventor(s): 広渡祐史、岡本奈美、後藤信哉
  • Industrial Property Rights Holder: 東ソー株式会社/学校法人東海大学
  • Industrial Property Number: 特許取得、特許第4693563
  • Acquisition Date: 2011-03-04