2011 Fiscal Year Final Research Report
Immunologic Mechanisms in Acute Coronary Syndrome through TRAIL/DR5 pathway
| Project/Area Number |
21590912
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
SATO Kayoko 東京女子医科大学, 医学部, 助教 (20246482)
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| Co-Investigator(Kenkyū-buntansha) |
SAWABE Motoji 地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター (30196331)
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| Co-Investigator(Renkei-kenkyūsha) |
HAGIWARA Nobuhisa 東京女子医科大学, 医学部, 教授 (00180802)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 急性冠症候群 / 免疫・炎症 / アポトーシス |
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| Research Abstract |
Development of atherosclerosis and unstable plaque, which cause acute coronary syndrome(ACS), are highly associated with chronic inflammation and immunological mechanisms. In this study we found that, (1) in unstable plaque, there are abundant TRAIL-positive CD4 T cells, DR5-positive vascular smooth muscle cells and endothelial cells, and apoptosis of target cells induced through the TRAIL/DR5 pathway, (2) inflammatory cytokine TNFαproduced by CD4 T cells increase DR5 and destabilizes plaque, (3) monitoring of soluble TRAIL in peripheral blood is a potential immunological biomarker for assessing plaque stability and disease severity.
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