2011 Fiscal Year Final Research Report
Comparison between imtravascular imaging and pathological findings of vulnerable plaque and assessment of the mechanism of plaque stabilization.
| Project/Area Number |
21590913
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 血管内イメージングのデバイス / 不安定プラーク |
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| Research Abstract |
We compared the pathological findings to the imaging assessed by tissue characterization by intravascular ultrasound(IVUS) of the vulnerable plaque of WHHL-MI rabbit and concluded that tissue characterization by IVUS was compatible to the pathological findings. The vulnerable plaques of WHHL-MI rabbits treated by pitavastatin were compared to those without treatment by serial IVUS assessment. There were no significant changes in plaque volume and components during the treatment between groups ; however, the fibrous contents significantly increased and lipid contents significantly decreased in the inner part(near the vessel lumen) of the plaques during the study period and between the groups. This findings suggested that the plaque stabilization shown by the pathology is represented by the changes in the inner components of the plaque assessed by the tissue characterization by IVUS.
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