2011 Fiscal Year Final Research Report
Clinical application of newly developed h-chymase assay method : changes in acute coronary syndrome and association with coronary risk factors
| Project/Area Number |
21590916
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 心臓病態学 |
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| Research Abstract |
Chymase assay method was established using the specific chymase inhibitor with modified angiotensinI(AngI). Analysis in circulating mononuclear leukocyte(CML) of the patients post myocardial infarction(MI) revealed significant increase in acute phase(1-2 days) and the level of increase was positively correlated with the MI severity. In the analysis of stable angina patient chymase activity in CML was significantly higher in male and positively correlated with white blood cell number, c-reactive protein, HOMA index, degree of chronic kidney disease(CKD), suggesting that mild inflammatory status, glucose intolerance or CKD facilitate chymase levels in CML. In collaborative work with Ryuku University acute venous infusion of free fatty acid significantly increased serine protease dependent Ang II forming activity in CML, which was associated with endothelial dysfunction. In collaborative work with Kagawa University unilateral urethral clipping was associated with increased chymase activity only in the affected kidney and increased renal Ang IIlevels.
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Research Products
(19 results)
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[Journal Article] Blood glucose level and survival in streptozotocin-treated human chymase transgenic mice2011
Author(s)
Rafiq. K., Sherajee. S. J., Fan. Y.-Y., Nakano.D., Hitomi. H., Nishiyama. A., Fujisawa. Y., Takahashi. Y., Matsuura. J., Hase. N., Urata. H.
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Journal Title
Chinese Journal of Physiology
Volume: 54
Pages: 30-35
Peer Reviewed
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[Journal Article] Dell' ltalia L. J., Husain A.、Mast cell chymase limits the cardiac efficacy of Ang I. converting enzyme inhibitor therapy in rodents2010
Author(s)
Wei C. C., Hase N., Inoue Y., Bradley E. W., Yahiro E., Li M., Naqvi N., Powell P. C., Shi K., Takahashi Y., Saku K., Urata H.
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Journal Title
The Journal of clinical investigation
Volume: 120
Pages: 1229-1239
Peer Reviewed
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[Journal Article] Free fatty acid causes leukocyte activation and resultant endothelial dysfunction through enhanced angiotensin II production in mononuclear and polymorphonuclear cells2010
Author(s)
Azekoshi, Yoko ; Yasu, Takanori ; Watanabe, Saiko ; Tagawa, Tatsuya ; Abe, Satomi ; Yamakawa, Ken ; Uehara, Yoshinari ; Momomura, Shinichi ; Urata, Hidenori ; Ueda, Shinichiro
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Journal Title
Hypertension
Volume: 56
Pages: 136-142
Peer Reviewed
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[Journal Article] Contribution of chymase-dependent angiotensin II formation to the progression of tubulointerstitial fibrosis in obstructed kidneys in hamsters2009
Author(s)
Fan Y. Y., Nishiyama A., Fujisawa Y., Kobori H., Nakano D., Matsuura J., Hase N., Hitomi H., Kiyomoto H., Urata H., Kohno M.
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Journal Title
Journal of Pharmacological Sciences
Volume: 111
Pages: 82-90
Peer Reviewed
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[Presentation] Higher chymase dependent angiotensin II-forming activity in the circulating mononuclear leukocyte is a significant contributing factor for atrial fibrillation2010
Author(s)
Okamura K., Inoue Y., Uehara Y., Maruyama S., Sumi S., Furuyama S., Kodama S., Andoh C., Niimura H., Tojo H., Miyoshi K., Tsuchiya Y., Miura S., Yamanouchi Y., Saku K., Urata H.
Organizer
ACC 2010 59th Annual Scientific Session
Year and Date
2010-03-16
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[Presentation] Higher Chymase Dependent Angiotensin II-Forming Activity in the Circulating Mononuclear Leukocyte is a Significant Contributing Factor for Atrial Fibrillation2010
Author(s)
Okamura K., Inoue Y., Uehara Y., Matsumoto K., Maruyama S., Sumi S., Fukuda Y., Furuyama S., Kodama S., Andoh C., Niimura H., Kubota K., Tohjoh H., Miyoshi K., Miura S., Yamanouchi Y., Saku K., Urata H.
Organizer
第74回日本循環器学会総会・学術集会
Year and Date
2010-03-07
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[Presentation] Increased chymase-dependent Angiotensin II forming activity of circulating mononuclear leukocyte in patients with coronary artery disease2009
Author(s)
Inoue Y., Okamura K., Ide H., Maruyama S., Sumi S., Furuyama S., Kodama S., Ando C., Niimura H., Tojo H., Miyoshi K., Yamanouchi Y., Urata H.
Organizer
ESH2009 19th European Meeting on Hypertension
Year and Date
2009-06-14
