The role of soluble VEGF receptor in cardiovascular risk of metabolic syndrome and smoking

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590918
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Department of Clinical Research, National Hospital Organization Kyoto Medical Center
• Principal Investigator: WADA Hiromichi 独立行政法人国立病院機構(京都医療センター臨床研究センター), 展開医療研究部, 研究室長(先端医療技術開発) (20416209)
• Co-Investigator(Kenkyū-buntansha): SATOH Noriko 独立行政法人国立病院機構(京都医療センター臨床研究センター), 糖尿病研究部, 研究室長(臨床代謝栄養) (80373512)
• Project Period (FY): 2009 – 2011
• Keywords: メタボリックシンドローム / 喫煙

Research Abstract

The mechanisms that lead from obesity to atherosclerotic disease are not fully understood. Obesity involves angiogenesis in which vascular endothelial growth factor-A(VEGF-A) plays a key role. Soluble VEGF receptor-2(sVEGFR-2) acts as an endogenous inhibitor of VEGF-A. We demonstrated that serum levels of sVEGFR-2 are increased in sera from subjects with metabolic syndrome in association with insulin resistance. We also showed that the sVEGFR-2 level, as well as the body mass index, significantly increases after successful smoking cessation. A recent study reported that sVEGFR-2 also acts as an endogenous inhibitor of vascular endothelial growth factor-C(VEGF-C). We found that VEGF-C, rather than VEGF-A, is closely related to dyslipidemia and atherosclerosis.

Research Products

• [Journal Article] α1-Antitrypsin-low-density-lipoprotein serves as a marker of smoking-specific oxidative stress (2012)
  • Author(s): Wada H, Ura S, Satoh-Asahara N, Kitaoka S, Mashiba S, Akao M, Abe M, Ono K, Morimoto T, Fujita M, S himatsu A, Takahashi Y, Hasegawa K
  • Journal Title: J Atheroscler Thromb Volume: 19(1) Pages: 47-58
  • Peer Reviewed
• [Journal Article] Distinct Characteristics of Circulating Vascular Endothelial Growth Factor-A and C Levels in Human Subjects (2011)
  • Author(s): Wada H, Ura S, Kitaoka S, Satoh-Asahara N, Horie T, Ono K, Takaya T, Takanabe-Mori R, Akao M, Abe M, Morimoto T, Murayama T, Yokode M, Fujita M, Shimatsu A, Takahashi Y, Hasegawa K
  • Journal Title: PLoS ONE Volume: 6(12) Pages: e29351
  • Peer Reviewed
• [Journal Article] Soluble VEGF receptor-2 is increased in sera of subjects with metabolic syndrome in association with insulin resistance (2010)
  • Author(s): Wada H, Satoh N, Kitaoka S, Ono K, Morimoto T, Kawamura T, Nakano T, Fujita M, Kita T, Shimatsu A, Hasegawa K
  • Journal Title: Atherosclerosis Volume: 208(2) Pages: 512-7
  • Peer Reviewed
• [Presentation] Serum Levels of Vascular Endothelial Growth Factor-C are Associated with Dyslipidemia and Atheroscrelosis (2012)
  • Author(s): Shuichi Ura, Hiromichi Wada, Sh uji Kitaoka, Noriko Satoh-Asahara, Takahiro Horie, Koh Ono, Tomohide Takaya, Rieko Takanabe-Mori, Masaharu Akao, Mitsuru Abe, Tatsuya Morimoto, Masatoshi Fujita, Akira Shimatsu, Koji Hasegawa
  • Organizer: 第76回日本循環器学会年次集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-17
• [Presentation] α1-Antitrypsin-low-density-lipoprotein Serves as a Marker of Smoking-specific Oxidative Stress (2011)
  • Author(s): Hiromichi Wada, Noriko Satoh-Asahara, Shuichi Ura ; Akira Yamada ; Shuji Kitaoka, Masaharu Akao, Mitsuru Abe, Koh Ono, Tatsuya Morimoto, Masatoshi Fujita, Akira Shimatsu, Yuko Takahash i, Koji Hasegawa
  • Organizer: 第75回日本循環器学会年次集会
  • Place of Presentation: 横浜
  • Year and Date: 2011-08-04
• [Presentation] Soluble VEGF Receptor-2 is a Possible Novel Indicator of Impaired An giogenesis in Metabolic Syndrom (2010)
  • Author(s): Hiromichi Wada, Noriko Satoh, Shuji Kitaoka, Koh Ono, Tatsuya Morimoto, Teruhisa Kawamura, Tameo Nakano, Masatosh i Fujita, Toru Kita, Akira Shimatsu, Koji Hasegawa
  • Organizer: 第74回日本循環器学会年次集会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-07
• [Remarks]
  • URL: http://www.hosp.go.jp/～kyotolan/html/guide/medicalinfo/clinicalresearch/expand/translational.html