Effects of autonomic nervous activity and mechanical stress on the arrhythmogenesis in heart failure

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590920
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: INAGAKI Masashi 独立行政法人国立循環器病研究センター, 循環動態制御部, 室長 (80359273)
• Co-Investigator(Renkei-kenkyūsha): LI Meihua 独立行政法人国立循環器病研究センター, 循環動態制御部, 研究員 (60443496) ; HIDAKA Ichiro 独立行政法人国立循環器病研究センター, 循環動態制御部, 研究員 (70443497) ; HIRABAYASHI Satoko 東京大学, 大学院生 ; SEO Kinya 東京大学, 大学院生
• Project Period (FY): 2009 – 2011
• Keywords: 臨床心血管病態学 / 不整脈 / 電気生理学

Research Abstract

Using optical transmembrane potential mapping, we investigated the spatiotemporal effects of autonomic nerve stimulation and mechanical stress on the electrophysiological characteristics in heart failure rats after myocardial infarction.
1) Sympathetic nerve stimulation shortened ventricular action potential duration(APD) in heart failure rats after myocardial infarction. The shortening of APD was larger in the non-infarct area than in the infarct area. As a result, sympathetic nerve stimulation increased inhomogeneity of APD. Vagus nerve stimulation decreased the inhomogeneity of APD.
2) The volume pulse applied at the T wave of ECG induced a focal excitation. The focal excitation originated from the surrounding areas of infarction. When the volume pulse was applied after a proper coupling interval, the induced focal excitation developed to ventricular fibrillation.
3) Vagus nerve stimulation suppressed electrical remodeling in chronic heart failure.

Research Products

• [Journal Article] Medetomidine, anα(2)-Adrenergic Agonist, Activates Cardiac Vagal Nerve Through Modulation of Baroreflex Control (2012)
  • Author(s): Shimizu S, Akiyama T, Kawada T, Sata Y, Mizuno M, Kamiya A, Shishido T, Inagaki M, Shirai M, Sano S, Sugimachi M. 2.Shimizu S, Akiyama T, Kawada T, Sata Y, Mizuno M, Kamiya A, Shishido T, Inagaki M, Shirai M, Sano S, Sugimachi M
  • Journal Title: Circ J Volume: 76 Pages: 152-159
• [Journal Article] Adaptation of the respiratory controller contributes to the attenuation of exercise hyperpnea in endurance-trained athletes (2012)
  • Author(s): Miyamoto T, Inagaki M, Takaki H, Kawada T, Shishido T, Kamiya A, Sugimachi M
  • Journal Title: Eur J Appl Physiol Volume: 112 Pages: 237-251
• [Journal Article] 植込み型除細動器用致死性不整脈検出アルゴリズムの高速・高精度化 (2011)
  • Author(s): 阿部誠、テルマ・スガイ・ケイコ、吉澤誠、本間経康、杉田典大、清水一夫、後藤萌、稲垣正司、杉町勝、砂川賢二
  • Journal Title: 生体医工学 Volume: 49 Pages: 932-938
• [Journal Article] 重回帰分析を用いた致死性不整脈検出アルゴリズムに関する検討 (2010)
  • Author(s): 阿部誠、テルマ・スガイ・ケイコ、吉澤誠、山家智之、清水一夫、後藤萌、稲垣正司、杉町勝、砂川賢二
  • Journal Title: 生体医工学 Volume: 48 Pages: 577-583
• [Journal Article] Structural heterogeneity in the ventricular wall plays a significant role in the initiation of stretch-induced arrhythmias in perfused rabbit right ventricular tissues and whole heart preparations (2010)
  • Author(s): Seo K, Inagaki M, Nishimura S, Hidaka I, Sugimachi M, Hisada T, Sugiura S
  • Journal Title: Circ Res Pages: 176-184
• [Journal Article] Feedback control of multiple hemodynamic variables with multiple cardiovascular drugs (2009)
  • Author(s): Sugimachi M, Uemura K, Kamiya A, Shimizu S, Inagaki M, Shishido T
  • Journal Title: Conf Proc IEEE Eng Med Biol Soc Volume: 2009 Pages: 2030-2032
• [Journal Article] Macroscopic two-pump two-vasculature cardiovascular model to support treatment of acute heart failure (2009)
  • Author(s): Sugimachi M, Sunagawa K, Uemura K, Kamiya A, Shimizu S, Inagaki M, Shishido T
  • Journal Title: Conf Proc IEEE Eng Med Biol Soc Volume: 2009 Pages: 2365-2368
• [Journal Article] Preliminary study on the detection of cardiac arrhythmias based on multiple simultaneous electrograms (2009)
  • Author(s): Sugai TK, Yoshizawa M, Abe M, Shimizu K, Inagaki M, Sugimachi M, Sunagawa K.
  • Journal Title: Conf Proc IEEE Eng Med Biol Soc Volume: 2009 Pages: 2498-2501
• [Presentation] アセチルコリンエステラーゼ阻害薬(ドネペジル)とロサルタンの長期併用投与による心筋梗塞後重症心不全ラットの心機能・長期生存率の改善作用 (2012)
  • Author(s): 李梅花、鄭燦、川田徹、稲垣正司、杉町勝
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道
  • Year and Date: 20120328-31
• [Presentation] Restoration of vegal tone by donepezil, on top of losartan treatment, markedly suppresses ventricular dysfunction and improves long-term survival in chronic heart failure rats (2011)
  • Author(s): M. Li, C. Zheng, T. Kawada, M. Inagaki, H. Takaki, M. Sugimachi
  • Organizer: ESC Congress 2011
  • Place of Presentation: Paris, France
  • Year and Date: 20110827-31
• [Presentation] Early vagal stimulation markedly prevented cardiac dysfunction in rats after acute myocardial infarction in addition to suppressing arrhythmic death (2011)
  • Author(s): M. Li, M. Inagaki, C. Zheng, T. Kawada, K. Uemura, T. Shishido, M. Sugimachi
  • Organizer: ESC Congress 2011
  • Place of Presentation: Paris, France
  • Year and Date: 20110827-31
• [Presentation] Fluid restriction improves cardiac function and survival in rats with chronic heart failure (2011)
  • Author(s): C. Zheng, M. Li, T. Kawada, M. Inagaki, T. Takaki, M. Sugimachi, K. Uemura, M. Arikawa, Y. Kakinuma, T. Sato
  • Organizer: ESC Congress 2011
  • Place of Presentation: Paris, France
  • Year and Date: 20110827-31
• [Presentation] Restoration of vagal tone by donepezil, on top of losartan treatment, markedly improves long-term survival in chronic heart failure rats (2011)
  • Author(s): Meihua Li, Can Zheng, Toru Kawada, Masashi Inagaki, Toshiaki Shishido, Masaru Sugimachi
  • Organizer: 第75回日本循環器学会総会・学術集会
  • Place of Presentation: 神奈川
  • Year and Date: 20110803-04
• [Presentation] Vagal stimulation promotes activation of cardiac stem cells in acute myocardial infarction rats (2011)
  • Author(s): Meihua Li, Masashi Inagaki, Can Zheng, Toru Kawada, Kazunori Uemura, Masaru Sugimachi
  • Organizer: 第75回日本循環器学会総会・学術集会
  • Place of Presentation: 神奈川
  • Year and Date: 20110803-04
• [Presentation] アセチルコリンエステラーゼ阻害薬とアンジオテンシンII受容体拮抗約の併用投与による心筋梗塞後重症心不全ラットの心機能・長期生存率の改善作用 (2011)
  • Author(s): 李梅花、鄭燦、川田徹、稲垣正司、杉町勝
  • Organizer: 第32回日本循環制御医学会総会
  • Place of Presentation: 富山
  • Year and Date: 20110610-11
• [Presentation] GPGPUを用いた心臓電気活動シミュレーション (2011)
  • Author(s): 日高一郎、稲垣正司、杉町勝
  • Organizer: 第50回日本生体医工学会大会
  • Place of Presentation: 東京
  • Year and Date: 20110429-0501
• [Presentation] GPGPUを用いた心臓電気活動の高速シミュレーションとリアルタイムレンダリングステムの開発 (2011)
  • Author(s): 日高一郎、稲垣正司、杉町勝
  • Organizer: 第50回日本生体医工学会大会
  • Place of Presentation: 東京
  • Year and Date: 20110429-0501
• [Presentation] Masaru Sugimachi Vagus Nerve Stimulation in Heart Failure (2011)
  • Author(s): Masashi Inagaki, Meihua Li, Kazunori Uemura, Toshiaki Shishido
  • Organizer: 4th Asia Pacific Heart Rhythm Society Scientific Session
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2011-09-22
• [Presentation] Vagal Stimulation Markedly Suppressed Arrhythmic Death Prevented Cardiac Dysfunction in Rats after Acute Myocardial Infarction (2010)
  • Author(s): Meihua Li, Masashi Inagaki, Can Zheng, Toru Kawada, Kazunori Uemura, Toshiaki Shishido, Masaru Sugimachi
  • Organizer: CSDS2010
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 20100923-26
• [Presentation] 重回帰分析を用いた致死性不整脈検出アルゴリズムに関する検討 (2010)
  • Author(s): 阿部誠、テルマケイコスガイ、吉澤誠、清水一夫、後藤萌、稲垣正司、杉町勝、砂川賢二
  • Organizer: 生体医工学シンポジウム2010(JBMES2010)
  • Place of Presentation: 北海道
  • Year and Date: 20100910-11
• [Presentation] Estimated Venous Return Surface and Cardiac Output Curve Precisely Predicts New Hemodynamics after Volume Change (2010)
  • Author(s): Sugimachi, Masaru Sunagwa, Kenji Uemura, Kazunori Kamiya, Atsunori Shimizu, Shuji Inagaki, Masashi Shishido Toshiaki
  • Organizer: IEEE EMBS2010
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 20100831-0904
• [Presentation] Medetomidine, an alpha2 adrenergic agonist enhances acetylcholine release from cardiac vegal nerve endings through central action (2010)
  • Author(s): S. Shimizu, T. Akiyama, T. Kawada, M. Inagaki, A. Kamiya, T. Shishido, S. Sano, M. Shirai, M. Sugimachi
  • Organizer: ESC Congress 2010
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 20100828-0901
• [Presentation] Computer simulation of cardiac excitation using general-purpose graphics processing unit(GPGPU) (2010)
  • Author(s): 日高一郎、稲垣正司、杉町勝
  • Organizer: 第49回日本生体医工学会大会
  • Place of Presentation: 大阪
  • Year and Date: 20100625-27
• [Presentation] 未来先進治療を支えるシミュレーション技術-生体のマルチスケール・マルチフィジックスシミュレーション (2010)
  • Author(s): 稲垣正司
  • Organizer: 第31回日本循環制御医学会総会
  • Place of Presentation: 大阪
  • Year and Date: 20100528-29
• [Presentation] GPGPUを用いた心臓電気活動シミュレーションの高速化 (2010)
  • Author(s): 日高一郎、稲垣正司、杉町勝
  • Organizer: 第31回日本循環制御医学会総会
  • Place of Presentation: 大阪
  • Year and Date: 20100528-29
• [Presentation] 急性期からの迷走神経の慢性電気刺激は心筋梗塞ラットの致死性不整脈と心臓リモデリングを抑制する (2010)
  • Author(s): 李梅花、稲垣正司、鄭燦、川田徹、上村和紀、宍戸稔聡、杉町勝
  • Organizer: 第31回日本循環制御医学会総会
  • Place of Presentation: 大阪
  • Year and Date: 20100528-29
• [Presentation] Mechanisms of Stretch-Induced Arrhythmias : A Multiphysics Simulation Study of Mechanoelectric Feedback (2010)
  • Author(s): Masashi Inagaki, Satoko Hirabayashi, Kinya Seo, Toshiaki Hisada, Masaru Sugimachi
  • Organizer: 第74回日本循環器学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 20100305-07
• [Presentation] Medetomidine, anα2-Adrenergic Agonist, Directly Activates Cardiac Parasympathetic Nerve (2010)
  • Author(s): Shuji Shimizu, Tsuyoshi Akiyama, Toru Kawada, Toshiaki Shishido, Atsunori kamiya, Masashi Inagaki, Mikiyasu Shirai, Masaru Sugimachi
  • Organizer: 第74回日本循環器学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 20100305-07
• [Presentation] Kenji Preliminary Study on the Detection of Cardiac Arrhythmias based on Multiple Simultaneous Electrograms (2009)
  • Author(s): Sugai, TelmaKeiko Yoshizawa, Makoto Abe, Makoto Inagaki, Msashi Sugimachi, Masaru Shimizu, Kazuo Sunagawa
  • Organizer: IEEE EMBC2009
  • Place of Presentation: Minneapolis, USA
  • Year and Date: 20090902-07
• [Presentation] 除細動器・心臓再同期装置に組み込み可能な、心拍出量モニターシステム (2009)
  • Author(s): 上村和紀、稲垣正司、清水一夫、根本和人、杉町勝
  • Organizer: 第48回日本生体医工学大会
  • Place of Presentation: 東京
  • Year and Date: 20090423-25
• [Book] Effects of Wall Stress on the Dynamics of Ventricular Fibrillation : A Computer Simulation Study of Mechanoelectric Feedback in "Mechanosensitivity of the Heart" (2009)
  • Author(s): SHirabayashi, M Inagaki, T Hisada, and M Sugimachi
  • Publisher: Springer