2011 Fiscal Year Final Research Report
Effects of autonomic nervous activity and mechanical stress on the arrhythmogenesis in heart failure
| Project/Area Number |
21590920
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
INAGAKI Masashi 独立行政法人国立循環器病研究センター, 循環動態制御部, 室長 (80359273)
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| Co-Investigator(Renkei-kenkyūsha) |
LI Meihua 独立行政法人国立循環器病研究センター, 循環動態制御部, 研究員 (60443496)
HIDAKA Ichiro 独立行政法人国立循環器病研究センター, 循環動態制御部, 研究員 (70443497)
HIRABAYASHI Satoko 東京大学, 大学院生
SEO Kinya 東京大学, 大学院生
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| Project Period (FY) |
2009 – 2011
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| Keywords | 臨床心血管病態学 / 不整脈 / 電気生理学 |
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| Research Abstract |
Using optical transmembrane potential mapping, we investigated the spatiotemporal effects of autonomic nerve stimulation and mechanical stress on the electrophysiological characteristics in heart failure rats after myocardial infarction.
1) Sympathetic nerve stimulation shortened ventricular action potential duration(APD) in heart failure rats after myocardial infarction. The shortening of APD was larger in the non-infarct area than in the infarct area. As a result, sympathetic nerve stimulation increased inhomogeneity of APD. Vagus nerve stimulation decreased the inhomogeneity of APD.
2) The volume pulse applied at the T wave of ECG induced a focal excitation. The focal excitation originated from the surrounding areas of infarction. When the volume pulse was applied after a proper coupling interval, the induced focal excitation developed to ventricular fibrillation.
3) Vagus nerve stimulation suppressed electrical remodeling in chronic heart failure.
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Research Products
(31 results)
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[Journal Article] Medetomidine, anα(2)-Adrenergic Agonist, Activates Cardiac Vagal Nerve Through Modulation of Baroreflex Control2012
Author(s)
Shimizu S, Akiyama T, Kawada T, Sata Y, Mizuno M, Kamiya A, Shishido T, Inagaki M, Shirai M, Sano S, Sugimachi M. 2.Shimizu S, Akiyama T, Kawada T, Sata Y, Mizuno M, Kamiya A, Shishido T, Inagaki M, Shirai M, Sano S, Sugimachi M
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Journal Title
Circ J
Volume: 76
Pages: 152-159
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[Presentation] Fluid restriction improves cardiac function and survival in rats with chronic heart failure2011
Author(s)
C. Zheng, M. Li, T. Kawada, M. Inagaki, T. Takaki, M. Sugimachi, K. Uemura, M. Arikawa, Y. Kakinuma, T. Sato
Organizer
ESC Congress 2011
Place of Presentation
Paris, France
Year and Date
20110827-31
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[Presentation] Medetomidine, an alpha2 adrenergic agonist enhances acetylcholine release from cardiac vegal nerve endings through central action2010
Author(s)
S. Shimizu, T. Akiyama, T. Kawada, M. Inagaki, A. Kamiya, T. Shishido, S. Sano, M. Shirai, M. Sugimachi
Organizer
ESC Congress 2010
Place of Presentation
Stockholm, Sweden
Year and Date
20100828-0901
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