2011 Fiscal Year Final Research Report
Molecular mechanism regulating mesenchymal cell dynamics during myocardial remodeling
| Project/Area Number |
21590927
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Mie University |
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Principal Investigator |
YOSHIDA Kyoko (IMANAKA kyoko) 三重大学, 大学院・医学系研究科, 准教授 (00242967)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAZAKI Hidetoshi 三重大学, 大学院・医学系研究科, 准教授 (00283987)
HARA Mari 三重大学, 医学部, 教務職員 (30176383)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 分子心臓病態学 / リモデリング / 心筋梗塞 / テネイシン / 細胞外マトリクス / 組織修復 / 間葉系幹細胞 |
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| Research Abstract |
After myocardial infarction, bone marrow derived mesenchymal stem cells are recruited to the damaged lesion and could be involved in myocardial tissue repair as well as residential fibroblasts. An extracellular matrix molecule, tenascin-C synthesized by both mesencymal stem cells and residential fibroblasts may accelerate tissue repair at least partly, by up-regulation of cytokine and chemokine production and facilitating recruitment of bone marrow derived cells.
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Research Products
(20 results)
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[Journal Article] Toward in vivo imaging of heart disease using a radiolabeled single-chain fv fragment targeting tenascin-c2011
Author(s)
Kobayashi N, Odaka K, Uehara T, Imanaka-Yoshida K, Kato Y, Oyama H, Tadokoro H, Akizawa H, Tanada S, Hiroe M, Fukumura T, Komuro I, Arano Y, Yoshida T, Irie T.
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Journal Title
Anal Chem
Volume: 83
Pages: 9123-9130
Peer Reviewed
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[Journal Article] Tenascin-c may aggravate left ventricular remodeling and function after myocardial infarction in mice2010
Author(s)
Nishioka T, Onishi K, Shimojo N, Nagano Y, Matsusaka H, Ikeuchi M, Ide T, Tsutsui H, Hiroe M, Yoshida T, Imanaka-Yoshida K
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Journal Title
Am J Physiol Heart Circ Physiol
Volume: 298
Pages: 1072-1078
Peer Reviewed
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[Journal Article] High prevalence of chronic myocarditis in dilated cardiomyopathy referred for left ventriculoplasty : Expression of tenascin c as a possible marker for inflammation2009
Author(s)
Tsukada B, Terasaki F, Shimomura H, Otsuka K, Otsuka K, Katashima T, Fujita S, Imanaka-Yoshida K, Yoshida T, Hiroe M, Kitaura Y.
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Journal Title
Hum Pathol
Volume: 40
Pages: 1015-1022
Peer Reviewed
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[Journal Article] Incremental prognostic values of serum tenascin-c levels with blood b-type natriuretic peptide testing at discharge in patients with dilated cardiomyopathy and decompensated heart failure2009
Author(s)
Fujimoto N, Onishi K, Sato A, Terasaki F, Tsukada B, Nozato T, Yamada T, Imanaka-Yoshida K, Yoshida T, Ito M, Hiroe M
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Journal Title
J Card Fail
Volume: 15
Pages: 898-908
Peer Reviewed
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