2011 Fiscal Year Final Research Report
The signaling network between endothelium and myocardium responsible for myocardial protection
| Project/Area Number |
21590930
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | angiopoietin-1 / 冠血管 / 冠静脈 / 心筋 / 内皮 / パラクラインシグナル |
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| Research Abstract |
To reveal the role of angiopoietin-1(Ang1) secreted from myocardium, we crossed Ang1flox mice withα-MHC-Cre transgenic mice to create cardiomyocyte-speicific Ang1 knockout(Ang1 CKO) mice. Ang1 CKO mice showed embryonic lethality between E12. 5 and 14. 5 with defects in(1) attachment between endocardial endothelium and ventricular traveculae,(2) development of both traveculae and compact layer, and(3) coronary vessel formation. We performed immunohistochemical analysis using CD31 antibody and found that Ang1 CKO mice exhibit the defects in coronary vein formation, namely' coronary venogenesis'.
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[Journal Article] Therapeutic activation of STAT3 by I nterleukin-11 ameliorates cardiac fibrosis after myocardial infaraction2010
Author(s)
Obana M, Maeda M, Takeda K, Hayama A, Mohri T, Yamashita T, Nakaoka Y, Takeda K, Matsumiya G, Azuma J, Fujio Y
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Journal Title
Circulation
Volume: 121
Pages: 684-691
Peer Reviewed
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[Presentation] Gab1 Negatively regulates Angiotensin II-accelerated Atherosclerosis in Apolipoprotein E Deficient Mice2011
Author(s)
Nakaoka Y, Higuchi K, Shioyama W, Taniyama Y, Arita Y, Hashimoto T, Fujio Y, Yamauchi-Takihara K, Morishita R, Hirano T, Komuro I
Organizer
第75回日本循環器学会学術集会
Place of Presentation
パシフィコ横浜(横浜市)
Year and Date
2011-08-04
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[Presentation] Gab1 is Critically involved in HGF-dependent Postnatal Angiogenesis after ischemia2011
Author(s)
Shioyama W, Nakaoka Y, Higuchi K, Minami T, Nishida K, Taniyama Y, Kidoya H, Arita Y, Hashimoto T, Fujio Y, Shirai M, Takakura N, Morishita R, Yamauchi-Takihara K, Kodama T, Hirano T, Mochizuki N, Komuro I
Organizer
日本循環器学会
Place of Presentation
京都国際会館(京都府)
Year and Date
2011-03-15
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[Presentation] Gab1 Negatively regulates Angiotensin II-accelerated Atherosclerosis in Apolipoprotein E Deficient Mice2010
Author(s)
Higuchi K, Nakaoka Y, Shioyama W, TaniyamaY, Arita Y, Hashimoto T, Fujio Y, Yamauchi-Takihara K, Morishita R, Hirano T, Komuro I
Organizer
2010 American Heart Association Scientific Sessions
Place of Presentation
米国・シカゴ
Year and Date
2010-11-15
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[Presentation] Interaction of Docking Protein Gab1 with Tyrosine Phosphatase SHP2 Regulates Hepatocyte Growth Factor-dependent ERK5 Activation and Upregulation of Kruppel-like Factor 2 in the Vascular Endothelium2009
Author(s)
Shioyama W., Nakaoka Y. Higuchi K, Minami T, Nishida K, Taniyama Y, Kidoya H, Arita Y, Hashimoto T, Fujio Y, Shirai M, Takakura N, Morishita R, Yamauchi-Takihara K, Kodama T, Hirano T, Mochizuki N, Komuro I
Organizer
American Heart Association, Scientific Sessions 2009
Place of Presentation
Orange County ConventionCenter(米国・フロリダ州オーランド)
Year and Date
2009-11-18
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[Presentation] Scaffolding Docking Protein Gab1 Has an Essential Role for HGF-dependent Endothelial Signaling and Angiogenesis after Hindlimb Ischemia2009
Author(s)
Nakaoka Y. Shioyama W., Higuchi K, Minami T, Nishida K, Taniyama Y, Kidoya H, Arita Y, Hashimoto T, Fujio Y, Shirai M, Takakura N, Morishita R, Yamauchi-Takihara K, Kodama T, Hirano T, Mochizuki N, Komuro I
Organizer
Basic Cardiovascular Sciences Conference 2009 : Molecular Mechanisms of Cardiovascular Disease
Place of Presentation
The Ritz-Carlton in Lake Las Vegas,米国ネバダ州ラスベガス)
Year and Date
2009-07-22
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