Role of SMP30 in the development of heart failure

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590935
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Fukushima Medical University
• Principal Investigator: TAKEISHI Yasuchika 福島県立医科大学, 医学部, 教授 (40272067)
• Co-Investigator(Kenkyū-buntansha): SAITOH Shu-ichi 福島県立医科大学, 医学部, 准教授 (20274962)
• Co-Investigator(Renkei-kenkyūsha): ISHIGAMI Akihito 東京都健康長寿医療センター研究所, 分子老化制御部門, 研究副部長 (50270658)
• Project Period (FY): 2009 – 2011
• Keywords: 加齢 / 心不全 / 酸化ストレス / アンジオテンシンII / アポトーシス

Research Abstract

In SMP30 knockout mice, cardiac function was more severely depressed after angiotensin II infusion compared to wild type mice. Angiotensin IIinduced increases in NADPH oxidase activity, ROS generation, c-Jun N terminal kinase activity, a ratio of Bax/Bcl, caspase activity, and numbers of TUNEL positive nuclei were greater in SMP30 knockout mice. Thus, SMP30 may have cardio-protective roles by antioxidant and anti-apoptotic effects.

Research Products

• [Journal Article] Crucial role of membrane type 1 matrix metalloproteinase(MT1-MMP) in RhoA/Rac1-dependent signaling pathways in thrombin-stimulated endothelial cells (2011)
  • Author(s): Ando K, Ishibashi T, Ohkawara H, Inoue N, Sugimoto K, Uekita H, Hu C, Okamoto Y, Takuwa Y, Takeishi Y
  • Journal Title: J Atheroscler Thromb Volume: 18 Pages: 762-773
  • Peer Reviewed
• [Journal Article] Differential regulation of diacylglycerol kinase isoform in human failing hearts (2011)
  • Author(s): Bilim O, Shishido T, Toyama S, Suzuki S, Sasaki T, Kitahara T, Sadahiro M, Takeishi Y, Kubota I
  • Journal Title: J Cardiothorac Surg Volume: 6 Pages: 65
  • Peer Reviewed
• [Journal Article] Diacylglycerol kinase inhibits ventricular tachyarrhythmias in a mouse model of heart failure-roles of canonical transient receptor potential(TRPC) channels- (2011)
  • Author(s): Hirose M, Takeishi Y, Niizeki T, Nakada T, Shimojo H, Kashihara T, Horiuchi-Hirose M, Kubota I, Mende U, Yamada M
  • Journal Title: Circ J Volume: 75 Pages: 2333-2342
  • Peer Reviewed
• [Journal Article] Involvement of membrane type 1-matrix metalloproteinase(MT1-MMP) in RAGE activation signaling pathways (2011)
  • Author(s): Kamioka M, Ishibashi T, Ohkawara H, Nagai R, Sugimoto K, Uekita H, Matsui T, Yamagishi S, Ando K, Sakamoto T, Takuwa Y, Wada I, Shiomi M, Maruyama Y, Takeishi Y
  • Journal Title: J Cell Physiol Volume: 226 Pages: 1554-1563
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• [Journal Article] Long-term clinical outcomes after deferral of percutaneous coronary intervention of intermediate coronary stenoses based on coronary pressure-derived fractional flow reserve (2011)
  • Author(s): Misaka T, Kunii H, Mizukami H, Sakamoto N, Nakazato K, Takeishi Y
  • Journal Title: J Cardiol Volume: 58 Pages: 32-37
  • Peer Reviewed
• [Journal Article] Very late stent thrombosis and neointimal plaque rupture after implantation of sirolimus-eluting stents : observations with angiography (2011)
  • Author(s): Sakamoto N, Nakazato K, Misaka T, Mizukami H, Kunii H, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Cardiovasc Intervent Ther Volume: 26 Pages: 263-268
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• [Journal Article] Impairment of FOS mRNA induction by a translation inhibitor puromycin in granulocytes from myelodysplastic syndrome patients (2011)
  • Author(s): Shikama Y, XiaoMin F, Shichishima T, Ono T, Noji H, Ikeda K, Ogawa K, Takeishi Y, Kimura J
  • Journal Title: Brit J Haematol Volume: 154 Pages: 525-527
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• [Journal Article] Suppressive effects of valsartan on microalbuminuria and CRP in patients with metabolic syndrome(Val-Mets) (2011)
  • Author(s): Shishido T, Konta T, Nishiyama S, Miyashita T, Miyamoto T, Takasaki S, Nitobe J, Watanabe T, Takeishi Y, Kubota I
  • Journal Title: Clin Exp Hypertens Volume: 33 Pages: 117-123
  • Peer Reviewed
• [Journal Article] 8-Hydroxy-2'-deoxyguanosine is a prognostic mediator for cardiac event (2011)
  • Author(s): Suzuki S, Shishido T, Ishino M, Katoh S, Sasaki T, Nishiyama S, Miyashita T, Miyamoto T, Nitobe J, Watanabe T, Takeishi Y, Kubota I
  • Journal Title: Eur J Clin Invest Volume: 41 Pages: 759-766
  • Peer Reviewed
• [Journal Article] Adaptive servo ventilation improves cardiac dysfunction and prognosis in chronic heart failure patients with Cheyne-Stokes respiration (2011)
  • Author(s): Yoshihisa A, Shimizu T, Owada T, Nakamura Y, Iwaya S, Yamauchi H, Miyata M, Hoshino Y, Sato T, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Int Heart J Volume: 52 Pages: 218-223
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• [Journal Article] Ezetimibe and vascular inflammation (2011)
  • Author(s): Ishibashi T, Takeishi Y
  • Journal Title: Curr Vasc Pharmacol Volume: 9 Pages: 99-108
  • Peer Reviewed
• [Journal Article] Pleiotropic effects of ARB in diabetes mellitus (2011)
  • Author(s): Saitoh S, Takeishi Y
  • Journal Title: Curr Vasc Pharmacol Volume: 9 Pages: 136-144
  • Peer Reviewed
• [Journal Article] Serum YKL-40 predicts adverse clinical outcomes in patients with chronic heart failure (2010)
  • Author(s): Bilim O, Takeishi Y, Kitahara T, Ishino M, Sasaki T, Suzuki S, Shishido T, Kubota I
  • Journal Title: J Card Fail Volume: 16 Pages: 873-879
  • Peer Reviewed
• [Journal Article] Advanced glycation end product mediated matrix metallo-proteinase-9 and apoptosis via renin-angiotensin system in type 2 diabetes (2010)
  • Author(s): Ishibashi T, Kawaguchi M, Sugimoto K, Uekita H, Sakamoto N, Yokoyama K, Maruyama Y, Takeishi Y
  • Journal Title: J Atheroscler Thromb Volume: 17 Pages: 578-589
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• [Journal Article] Tricuspid valvular dysplasia and its differentiation from Ebstein's anomaly (2010)
  • Author(s): Iwai-Takano M, Watanabe M, Otake H, Kobayashi A, Oikawa M, Machii H, Misaka T, Watanabe T, Takeishi Y
  • Journal Title: J Echocardiogr Volume: 8 Pages: 137-139
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• [Journal Article] Blockade of renin-angiotensin system attenuates advanced glycation end products-mediated signaling pathways (2010)
  • Author(s): Kamioka M, Ishibashi T, Sugimoto K, Uekita H, Nagai R, Sakamoto N, Ando K, Ohkawara H, Teramoto T, Maruyama Y, Takeishi Y
  • Journal Title: J Atheroscler Thromb Volume: 17 Pages: 590-600
  • Peer Reviewed
• [Journal Article] Metabolic regulation of coronary vascular tone : role of hydrogen peroxide, purinergic components, and angiotensin (2010)
  • Author(s): Kaneshiro T, Saitoh S, Machii H, Yamaguchi O, Ishibashi T, Maruyama Y, Takeishi Y
  • Journal Title: Eur J Pharmacol Volume: 645 Pages: 127-134
  • Peer Reviewed
• [Journal Article] Serum midkine as a predictor of cardiac events in patients with chronic heart failure (2010)
  • Author(s): Kitahara T, Shishido T, Suzuki S, Katoh S, Sasaki T, Ishino M, Nitobe J, Miyamoto T, Miyashita T, Watanabe T, Takeishi Y, Kubota I
  • Journal Title: J Card Fail Volume: 16 Pages: 308-313
  • Peer Reviewed
• [Journal Article] Aging impairs myocardium-induced dilation in coronary arterioles : role of hydrogen peroxide and angiotensin (2010)
  • Author(s): Machii H, Saitoh S, Kaneshiro T, Takeishi Y
  • Journal Title: Mech Ageing Dev Volume: 131 Pages: 710-717
  • Peer Reviewed
• [Journal Article] Prognostic study of cardiac and renal events in Japanese patients with chronic kidney disease and cardiovascular risk using myocardial perfusion SPECT : J-ACCESS 3 study design (2010)
  • Author(s): Nakamura S, Yuhei K, Hase H, Hatta T, Nishimura S, Moroi M, Nakagawa S, Kasai T, Kusuoka H, Takeishi Y, Nakajima K, Momose M, Takehana K, Nanasato M, Yoda S, Nishina H, Matsumoto N, Nishimura T
  • Journal Title: Ther Apher Dial Volume: 14 Pages: 379-385
  • Peer Reviewed
• [Journal Article] A long-term remission of renal amyloidosis with nephrotic syndrome after autologous peripheral blood stem-cell transplantation (2010)
  • Author(s): Ogawa K, Ikeda K, Furukawa M, Harada-Shirado K, Mashimo Y, Takahashi H, Matsumoto H, Kimura S, Shichishima-Nakamura A, Ohkawara H, Hashimoto Y, Asahi K, Noji H, Ohto H, Takeishi Y
  • Journal Title: Fukushima J Med Sci Volume: 56 Pages: 151-156
  • Peer Reviewed
• [Journal Article] Hematopoietic stem cell transplantation in the department of hematology (2010)
  • Author(s): Ogawa K, Noji H, Furukawa M, Harada-Shirado K, Mashimo Y, Takahashi H, Matsumoto H, Kimura S, Shichishima-Nakamura A, Ohkawara H, Ikeda K, Ohto H, Takeishi Y
  • Journal Title: Fukushima J Med Sci Volume: 56 Pages: 107-114
  • Peer Reviewed
• [Journal Article] Preventive effects of pravastatin on thrombin-triggered vascular responses via Akt/eNOS and RhoA/Rac1 pathways in vivo (2010)
  • Author(s): Ohkawara H, Ishibashi T, Saitoh S, Inoue N, Sugimoto K, Kamioka M, Uekita H, Kaneshiro T, Ando K, Takuwa Y, Maruyama Y, Takeishi Y
  • Journal Title: Cardiovasc Res Volume: 88 Pages: 492-501
  • Peer Reviewed
• [Journal Article] Hydrogen peroxide generated from cardiac myocytes impacts metabolic dilation in coronary arterioles (2010)
  • Author(s): Otake A, Saitoh S, Takeishi Y
  • Journal Title: Int Heart J Volume: 51 Pages: 125-128
  • Peer Reviewed
• [Journal Article] High serum level of neopterin is a risk factor of patients with heart failure (2010)
  • Author(s): Sasaki T, Takeishi Y, Suzuki S, Niizeki T, Kitahara T, Katoh S, Ishino M, Shishido T, Kubota I
  • Journal Title: Int J Cardiol Volume: 145 Pages: 318
  • Peer Reviewed
• [Journal Article] Low concentration of serum haptoglobin has impact on understanding complex pathophysiology in patients with acquired bone marrow failure syndromes (2010)
  • Author(s): Shichishima T, Ikeda K, Takahashi N, Kameoka J, Tajima K, Murai K, Tamai Y, Shichishima-Nakamura A, Akutsu K, Noji H, Okamoto M, Kimura H, Harigae H, Oyamada T, Kamesaki T, Takeishi Y, Sawada K
  • Journal Title: Int J Hematol Volume: 91 Pages: 602-610
  • Peer Reviewed
• [Journal Article] The nitric oxide synthase family and left ventricular diastolic function (2010)
  • Author(s): Takeishi Y
  • Journal Title: Circ J Volume: 74 Pages: 2556-2557
  • Peer Reviewed
• [Journal Article] Survival of a refractory ventricular fibrillation by cooperative treatments (2010)
  • Author(s): Tase C, Ohno Y, Hasegawa A, Tsukada Y, Shimada J, Ikegami Y, Sakamoto N, Takeishi Y
  • Journal Title: Fukushima J Med Sci Volume: 56 Pages: 139-143
  • Peer Reviewed
• [Journal Article] Flow mediated dilatation identifies impaired endothelial function in patients with sleep apnea syndrome (2010)
  • Author(s): Yoshihisa A, Owada T, Hoshino Y, Miyata M, Misaka T, Sato T, Suzuki S, Sakamoto N, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Ishibashi T, Takeishi Y
  • Journal Title: Fukushima J Med Sci Volume: 56 Pages: 115-120
  • Peer Reviewed
• [Journal Article] Factors correlated with plasma renin activity in general Japanese population (2009)
  • Author(s): Abiko H, Konta T, Hao Z, Takasaki S, Suzuki K, Ichikawa K, Ikeda A, Shibata Y, Takeishi Y, Kawata S, Kato T, Kubota I
  • Journal Title: Clin Exp Nephrol Volume: 13 Pages: 130-137
  • Peer Reviewed
• [Journal Article] Diacylglycerol kinase inhibits Gaq-induced atrial remodeling in transgenic mice (2009)
  • Author(s): Hirose M, Takeishi Y, Niizeki T, Shimojo H, Nakada T, Kubota I, Nakayama J, Mende U, Yamada M
  • Journal Title: Heart Rhythm Volume: 6 Pages: 78-84
  • Peer Reviewed
• [Journal Article] Genetic polymorphisms of paraoxonase-1 are associated with chronic kidney disease in Japanese women (2009)
  • Author(s): Ichikawa K, Konta T, Emi M, Toriyama S, Takasaki S, Ikeda A, Shibata Y, Takabatake N, Takeishi Y, Kato T, Kawata S, Kubota I
  • Journal Title: Kidney Int Volume: 76 Pages: 183-189
  • Peer Reviewed
• [Journal Article] In a non-diabetic Japanese population, the combination of macroalbuminuria and increased urine beta 2-microglobulin predicts a decline of renal function (2009)
  • Author(s): Ikeda A, Konta T, Takasaki S, Hao Z, Suzuki K, Sato H, Shibata Y, Takeishi Y, Kato T, Kawata S, Kubota I
  • Journal Title: Nephrol Dial Transpl Volume: 24 Pages: 841-847
  • Peer Reviewed
• [Journal Article] Combination of conventional biomarkers for risk stratification in chronic heart failure (2009)
  • Author(s): Niizeki T, Takeishi Y, Kitahara T, Suzuki S, Sasaki T, Ishino M, Kubota I
  • Journal Title: J Cardiol Volume: 53 Pages: 179-187
  • Peer Reviewed
• [Journal Article] RhoA and Rac1 changes in the atherosclerotic lesions of WHHLMI rabbits (2009)
  • Author(s): Ohkawara H, Ishibashi T, Shiomi M, Sugimoto K, Uekita H, Kamioka M, Takuwa Y, Teramoto T, Maruyama Y, Takeishi Y
  • Journal Title: J Atheroscler Thromb Volume: 16 Pages: 846-856
  • Peer Reviewed
• [Journal Article] Role of LOX-1 in monocyte adhesion-triggered redox, Akt/eNOS and Ca2+signaling pathways in endothelial cells (2009)
  • Author(s): Sakamoto N, Ishibashi T, Sugimoto K, Sawamura T, Sakamoto T, Inoue N, Saitoh S, Kamioka M, Uekita H, Ohkawara H, Suzuki K, Teramoto T, Maruyama Y, Takeishi Y
  • Journal Title: J Cell Physiol Volume: 220 Pages: 706-715
  • Peer Reviewed
• [Journal Article] LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells (2009)
  • Author(s): Sugimoto K, Ishibashi T, Sawamura T, Inoue N, KamiokaM, Uekita H, Ohkawara H, Sakamoto T, Sakamoto N, Okamoto Y, Takuwa Y, Kakino A, Fujita Y, Tanaka T, Teramoto T, Maruyama Y, Takeishi Y
  • Journal Title: Cardiovasc Res Volume: 84 Pages: 127-136
  • Peer Reviewed
• [Journal Article] Mast cells contribute to flow restoration by bone marrow cell transplantation in rats with ischemic limbs (2009)
  • Author(s): Tajima H, Iwai-Takano M, Yaoita H, Ogawa K, Yamaki T, Takeishi Y, Maruyama Y
  • Journal Title: Int Heart J Volume: 50 Pages: 247-257
  • Peer Reviewed
• [Journal Article] A novel polymorphism in CDC6 is associated with the decline in lung function of ex-smokers in COPD (2009)
  • Author(s): Takabatake N, Toriyama S, Igarashi A, Tokairin Y, Takeishi Y, Konta T, Inoue S, Abe S, Shibata Y, Kubota I
  • Journal Title: Biochem Bioph Res Co Volume: 381 Pages: 554-559
  • Peer Reviewed
• [Journal Article] Regulation of coronary vascular tone via redox modulation in the α1-adrenergic-angiotensin-endothelin axis of the myocardium (2009)
  • Author(s): Yamaguchi O, Kaneshiro T, Saitoh S, Ishibashi T, Maruyama Y, Takeishi Y
  • Journal Title: Am J Physiol-Heart C Volume: 296 Pages: H226-H232
  • Peer Reviewed
• [Journal Article] Participation of mast cells in angiogenesis in the border zone of myocardial infarction in rats (2009)
  • Author(s): Yamaki T, Iwai-Takano M, Yaoita H, Ogawa K, Tajima H, Takeishi Y, Maruyama Y
  • Journal Title: J Med Ultrason Volume: 36 Pages: 119-127
  • Peer Reviewed
• [Journal Article] Role of Toll-like receptor mediated signaling pathway in ischemic heart (2009)
  • Author(s): Takeishi Y, Kubota I
  • Journal Title: Front Biosci Volume: 14 Pages: 2553-2558
  • Peer Reviewed
• [Journal Article] Maturity-dependent fractionation of neutrophil progenitors : A new method to examine in vivo expression profiles of differentiation-regulating genes
  • Author(s): Hu H, Shikama Y, Shichishima T, Ikeda K, Akutsu K, Ono T, Kimura H, Ogawa K, Noji H, Takeishi Y, Kimura J
  • Journal Title: Exp Hematol Volume: (in press)
  • Peer Reviewed
• [Presentation] Senescence marker protein 30 inhibits angiotensin II-induced cardiac remodeling (2011)
  • Author(s): Misaka T, Suzuki S, Miyata M, Kobayashi A, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Orlando, USA
  • Year and Date: 20110000
• [Presentation] Distinct prognostic factors in patients with chronic heart failure and chronic kidney disease (2011)
  • Author(s): Sato T, Misaka T, Ohwada T, Yamauchi H, Yoshihisa A, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Orlando, USA
  • Year and Date: 20110000
• [Presentation] Overnight use of adaptive servo ventilation reduces cardiac overload and improves renal function in patients with chronic heart failure and Cheyne-Stokes respiration (2011)
  • Author(s): Yoshihisa A, Suzuki S, Miyata M, Sato T, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitho S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Orlando, USA
  • Year and Date: 20110000
• [Presentation] Comparisons of prognostic factors between chronic heart failure patients with and without atrial fibrillation (2011)
  • Author(s): Sato T, Misaka T, Nakamura Y, Owada T, Yoshihisa A, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Orlando, USA
  • Year and Date: 20110000
• [Presentation] Cardiac-specific overexpression of high mobility group box 1(HMGB1) attenuates cardiac dysfunction induced by pressure overload (2011)
  • Author(s): Funayama A, Netsu S, Ishino M, Otaki Y, Honda S, Hasegawa H, Kadowaki S, Narumi T, Nishiyama S, Takahashi H, Arimoto T, Miyashita T, Miyamoto T, Watanabe T, Woo C, Abe J, Kuwahara K, Nakao K, Takeishi Y, Kubota I
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Orlando, USA
  • Year and Date: 20110000
• [Presentation] Senescence marker protein-30 deficiency impairs myocardium-induced dilation in coronary arterioles associated with reactive oxygen species in aging (2011)
  • Author(s): Mizukami H, Saitoh S, Yamada S, Machii H, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Orlando, USA
  • Year and Date: 20110000
• [Presentation] The importance of serial renal function measurements in chronic heart failure (2011)
  • Author(s): Sato T, Nakamura Y, Shimizu T, Misaka T, Yoshihisa A, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Orlando, USA
  • Year and Date: 20110000
• [Presentation] Aging impairs endothelium dependent dilation via thiol-oxidation in coronary arterioles in SMP 30 deficiency mice (2011)
  • Author(s): Yamada S, Saitoh S, Mizukami H, Machii H, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Orlando, USA
  • Year and Date: 20110000
• [Presentation] Over expressed phoshodiesterase 3A regulates cardiac function and protects hearts from ischemia/reperfusion injury (2011)
  • Author(s): Oikawa M, Lim S, Jeon K, Knight W, Miller C, Cai Y, Blaxall B, Abe J, Takeishi Y, Yan C
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Orlando, USA
  • Year and Date: 20110000
• [Presentation] Deficiency of senescence marker protein 30 exacerbates angiotensin II-induced cardiac remodeling (2011)
  • Author(s): Misaka T, Suzuki S, Miyata M, Kobayashi A, Saitoh S, Ishigami A, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology
  • Place of Presentation: Paris, France
  • Year and Date: 20110000
• [Presentation] Senescence marker protein-30 deficiency impairs myocardium induced dilation in coronary arterioles associated with reactive oxygen species in aging (2011)
  • Author(s): Mizukami H, Saitoh S, Yamada S, Machii H, Suzuki H, Takeishi Y
  • Organizer: The 28th Annual Meeting of the International Society for Heart Research Japanese Section
  • Place of Presentation: Tokyo
  • Year and Date: 20110000
• [Presentation] MT1-MMP controls Akt-dependent Fox01 activation in TNF-α-induced signaling pathways of endothelial cell apoptosis and haemostasis (2010)
  • Author(s): Ohkawara H, Ishibashi T, Ando K, Sugimoto K, Sakamoto N, Uekita H, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Chicago, Illinois, USA
  • Year and Date: 20101100
• [Presentation] Aging impairs myocardium-induced dilation in coronary arterioles : role of hydrogen peroxide and angiotensin (2010)
  • Author(s): Machii H, Saitoh S, Kaneshiro T, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Chicago, USA
  • Year and Date: 20100000
• [Presentation] Age-associated metabolic regulation in coronary vascular tone (2010)
  • Author(s): Machii H, Saitoh S, Kaneshiro T, Ishibashi T, Takeishi Y
  • Organizer: 20th World Congress of the International Society for Heart Research(ISHR)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20100000
• [Presentation] Cardiac myocyte modulates coronary vascular tone through H2O2, ADP, and Angiotensin (2010)
  • Author(s): Machii H, Saitoh S, Kaneshiro T, Ishibashi T, Takeishi Y
  • Organizer: 20th World Congress of the International Society for Heart Research(ISHR)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20100000
• [Book] C.慢性心不全の治療11.鉄欠乏状態の慢性心不全患者において、鉄欠乏性貧血治療薬ferric carboxymaltoseの静注は症状を改善するか? EBM循環器疾患の治療 (2012)
  • Author(s): 及川雅啓,斎藤修一,竹石恭知
  • Total Pages: 219-222
  • Publisher: 中外医学社
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  • Total Pages: 357-361
  • Publisher: 南江堂
• [Book] 心硬化症候群症候群ハンドブック (2011)
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  • Total Pages: 174
  • Publisher: 中山書店
• [Book] III救急外来から入院1.病態・血行動態をどのように把握するか血液マーカー徹底ガイド心不全Q & A-プレホスピタルから慢性期まで- (2010)
  • Author(s): 義久精臣,小林淳,竹石恭知
  • Total Pages: 72-78
  • Publisher: 総合医学社
• [Book] I.症候編1.全身的に見られる症候チアノーゼ今日の診断指針第6版 (2010)
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• [Book] II.疾患の病因と病態3. Toll-like receptorと心臓リモデリングAnnual Review循環器 (2009)
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• [Book] 3.不整脈,失神:心臓電気生理検査で異常が出ないときは、睡眠時無呼吸症を疑え循環器検査のグノーティ・セアウトンー過信せず侮らず、謙虚で緻密な検査とは (2009)
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