2011 Fiscal Year Final Research Report
Cardiac remodeling and treatment due to brain-heart axis related with adiponectin expression in the heart
| Project/Area Number |
21590941
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | BDNF / 肥満 / 食事制限 |
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| Research Abstract |
Brain-derived neurotrophic factor(BDNF), a member of the neurotrophin family of neurotrophic factors, has important functions in the peripheral and central nervous system of vertebrates. BDNF was originally isolated from the brain, but it is also expressed in the non-neural tissues. BDNF is expressed in cardiac muscle and may modulate cardiac function. Caloric restriction(CR) is beneficial for myocardial ischemia through BDNA signaling pathway. Moreover, CR in the obesity is improves myocardial damage and is closely related with the increase of hyppocampal BDNF mRNA. However, the relation between BDNF and heart disease is controversial. My data showed that cardiac and hyppocampal expression of BDNF can be induced by food restriction in obesity and that induced BDNF signaling can be beneficial in cardiac dysfunction. Moreover, physical activity became increased by CR after 3 months.
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