Analysis of activation mechanism of cardiac p300/GATA4 pathway during heart failure

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590944
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: University of Shizuoka
• Principal Investigator: MORIMOTO Tatsuya 静岡県立大学, 薬学部, 教授 (50390779)
• Project Period (FY): 2009 – 2011
• Keywords: 心筋細胞肥大 / GATA4 / p300 / プロテオミクス / 転写因子

Research Abstract

GATA4 forms a large complex with an intrinsic histone acetyltransferase, p300 and these factors are involved in transcriptional regulation during myocardial cell hypertrophy. Moreover, noble p300/GATA4 binding partners, Cdk9, Iin1, RbAp48, and RbAp46 form a functional complex with p300/GATA4 and suppress hypertrophic responses in cardiomyocytes.

Research Products

• [Journal Article] Cyclin-dependent kinase 9 forms a complex with GATA4 and is involved in the differentiation of mouse ES cells into cardiomyocytes (2011)
  • Author(s): Kaichi S, Takaya T, Morimoto T, Sunagawa Y, Kawamura T, Ono K, Shimatsu A, Baba S, Heike T, Nakahata T, Hasegawa K
  • Journal Title: J Cell Physiol Volume: 226(1) Pages: 248-54
• [Journal Article] A natural p300-specific histone acetyltransferase inhibitor, curcumin, in addition to angiotensin converting enzyme inhibitor exerts beneficial effects on left ventricular systolic function after myocardial infarction in rats (2011)
  • Author(s): Sunagawa Y, Morimoto T, Wada H, Takaya T, Katanasaka Y, Kawamura T, Yanagi S, Marui A, Sakata R, Shimatsu A, Kimura T, Kakeya H, Fujita M, Hasegawa K
  • Journal Title: Circ J Volume: 75(9) Pages: 2151-9
• [Journal Article] Innovative preparation of curcumin for Improved oral bioavailability (2011)
  • Author(s): Sasaki H, Sunagawa Y, Takahashi K, Imaizumi A, Fukuda H, Hashimoto T, Wada H, Katanasaka Y, Kakeya K, Fujita M, Hasegawa K, Morimoto T
  • Journal Title: Biol Pharm Bull Volume: 34(5) Pages: 660-5
• [Journal Article] Cyclin-dependent kinsase-9 is a component of p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes (2010)
  • Author(s): Sunagawa Y, Morimoto T, Takaya T, Wada H, Kawamura T, Fujita M, Shimatsu A, Kita T, Hasegawa K
  • Journal Title: J Biol Chem Volume: 285(13) Pages: 9556-68
• [Journal Article] Aldosterone Signaling Associates with p300/GATA4 Transcriptional Pathway during Hypertrophic Responses in Cardiomyocytes (2010)
  • Author(s): Yoshida Y, Morimoto T, Takaya T, Kawamura T, Sunagawa Y, Wada H, Fujita M, Shimatsu A, Kita T, Hasegawa K
  • Journal Title: Circ J Volume: 74(1) Pages: 156-62
• [Journal Article] Left Ventricular Expression of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Failing Rat Hearts (2010)
  • Author(s): Takaya T, Wada H, Morimoto T, Sunagawa Y, Kawamura T, Takanabe-Mori R, Shimatsu A, Fujita Y, Sato Y, Fujita M, Kimura T, Sawamura T, Hasegawa K
  • Journal Title: Circ J Volume: 74(4) Pages: 723-9
• [Journal Article] Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice (2010)
  • Author(s): Kaichi S, Hasegawa K, Takaya T, Yokoo N, Mima T, Kawamura T, Morimoto T, Ono K, Baba S, Yamanaka S, Nakahata T, Heike T
  • Journal Title: Cardiovasc Res Volume: 88(2) Pages: 314-23
• [Journal Article] Excessive apoptosis as a downstream molecular event during the development of congenital heart diseases (2010)
  • Author(s): Kaichi S, Hasegawa K, Morimoto T
  • Journal Title: Circ J Volume: 74(11) Pages: 2297-8
• [Journal Article] Hasegawa K Novel heart failure therapy targeting transcriptional pathway in cardiomyocytes by a natural compound, curcumin (2010)
  • Author(s): Morimoto T, Sunagawa Y, Fujita M
  • Journal Title: Circ J Volume: 74(6) Pages: 1059-66
• [Journal Article] MicroRNA-1 and MicroRNA-133 in spontaneous myocardial differentiation of mouse embryonic stem cells (2009)
  • Author(s): Takaya T, Ono K, Kawamura T, Takanabe R, Kaichi S, Morimoto T, Wada H, Kita T, Shimatsu A, Hasegawa K
  • Journal Title: Circ J Volume: 73(8) Pages: 1397-8
• [Presentation] Protein Arginine Methyltransferase 5 and Methylosome Protein 50 Suppressies Hypertrophic Responses in Cardiomyocytes by Inhibition of p300/GATA4 Pathway (2011)
  • Author(s): Yasufumi Katanasaka, Yukiko Nakagawa, Yoichi Sunagawa, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: American Heart Association Scientific sessions 2011
  • Place of Presentation: Orland, USA
  • Year and Date: 20111112-16
• [Presentation] SNF5/INI1 Inhibits Hypertrophic Responses by Suppressing p300/GATA4-dependent Pathways in Cardiomyocytes (2011)
  • Author(s): Yoichi Sunagawa, Sugimoto Akihisa, Yukihiro Ishibashi, Yasufumi Katanasaka, Hiromichi Wada, Akira Shimatsu, Takeshi Kimura, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: American Heart Association Scientific sessions 2011
  • Place of Presentation: Orland, USA
  • Year and Date: 20111112-16
• [Presentation] Retinoblastoma Protein(Rb)-associated Protein 48 and 46 Form a Functional Complex With p300/GATA4 and Suppress Hypertrophic Responses in Cardiomyocytes (2011)
  • Author(s): Yoichi Sunagawa, Yasufumi Katanasaka, Taishi Terada, Yuichi Watanabe, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: American Heart Association Scientific sessions 2011
  • Place of Presentation: Orland, USA
  • Year and Date: 20111112-16
• [Presentation] A p300/GATA4 Transcriptional Pathway that Induces the Development of Heart Failure (2011)
  • Author(s): Tatsuya Morimoto, Koji Hasegawa
  • Organizer: The 7th Chica-Japan Cardiovascular Forum
  • Place of Presentation: Beijing, China
  • Year and Date: 20111014-15
• [Presentation] Transducin beta-like protein 1 inhibits hypertrophic responses by recruiting HDAC3 to p300/GATA4 pathways (2011)
  • Author(s): Masatoshi Namiki, Yasufumi Katanasaka, Yoichi Sunagawa, Hidetoshi Suzuki, Sho Hirota, Taishi Terada, Yukiko Nakagawa, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: The 7th Chica-Japan Cardiovascular Forum
  • Place of Presentation: Beijing, China
  • Year and Date: 20111014-15
• [Presentation] Receptor for activated protein kinase C1 is a novel component of p300/GATA4 complex and suppresses hypertrophic responses in cardiomyocytes (2011)
  • Author(s): Hidetoshi Suzuki, Yoichi Sunagawa, Yasufumi Katanasaka, Nobuko Okamura, Taishi Terada, Masatoshi Namiki, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: The 7th Chica-Japan Cardiovascular Forum
  • Place of Presentation: Beijing, China
  • Year and Date: 20111014-15
• [Presentation] Protein arginine ethyltransferase 5 suppresses hypertrophic gene transcription in rat cardiomyocytes through the inhibition of p300/GATA4 pathway (2011)
  • Author(s): Yasufumi Katanasaka, Yukiko Nakagawa, Yoichi Sunagawa, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: The 7th Chica-Japan Cardiovascular Forum
  • Place of Presentation: Beijing, China
  • Year and Date: 20111014-15
• [Presentation] Retinoblastoma protein(Rb)-associated protein 48 and 46 are novel p300/GATA4-binding partners involved in hypertrophic responses in cardiomyocytes (2011)
  • Author(s): Yoichi Sunagawa, Yasufumi Katanasaka, Taishi Terada, Yuichi Watanabe, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: American Heart Association BCVS2011
  • Place of Presentation: New Orleans, USA
  • Year and Date: 20110718-21
• [Presentation] Protein arginine metyltransferase 5 and methylosome protein 50 are novel component of p300/GATA4 complex involved in hypertrophic responses in cardiac myocytes (2011)
  • Author(s): Yasufumi Katanasaka, Yukiko Nakagawa, Yoichi Sunagawa, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: American Heart Association BCVS2011
  • Place of Presentation: New Orleans, USA
  • Year and Date: 20110718-21
• [Presentation] Retinoblastoma Protein(Rb)-associated Protein 48 and 46 are Novel Components of p300/GATA4 Complex Required for Hypertrophic Responses in Cardiomyocytes (2011)
  • Author(s): Yoichi Sunagawa, Yasufumi Katanasaka, Taishi Terada, Yuichi Watanabe, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: The 14th Annual International Tronto Heart Summit
  • Place of Presentation: Tronto, Canada
  • Year and Date: 20110609-11
• [Presentation] Protein arginine metyltransferase 5 and methylosome protein 50 are novel component of p300/GATA4 complex involved in hypertrophic responses in cardiac myocytes (2011)
  • Author(s): Yasufumi Katanasaka, Yukiko Nakagawa, Yoichi Sunagawa, Masatoshi Fujita, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: The 14th Annual International Tronto Heart Summit
  • Place of Presentation: Tronto, Canada
  • Year and Date: 20110609-11
• [Presentation] Heart f ailure therapy that targets nuclear signaling pathway in cardiomyocytes. from bench to bedside (2009)
  • Author(s): Tatsuya MorimotoKoji Hasegawa
  • Organizer: The 25th Annual Meeting of ISHR Japanese Section, Scientific Program
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 20091204-05
• [Presentation] A novel component of p300/GATA4 complex, Cyclin-dependent kinsase-9, is required for hypertrophic responses in cardiomyocytes (2009)
  • Author(s): Yoichi Sunagawa, Tatsuya Morimoto, Masatoshi FujitaKoji Hasegawa
  • Organizer: The 25th Annual Meeting of ISHR Japanese Section Scientific Program
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 20091204-05
• [Presentation] A natural p300-specific histone acetyltransferase inhibitor, curcumin, exerts synergistic effects with ACE inhibitor during systolic function restoration after myocardial infarction in rats (2009)
  • Author(s): Yoichi Sunagawa, Tatsuya Morimoto, Hiromichi Wada, Tomohide Takaya, Teruhisa Kawamura, Shigeki Yanagi, Akira Marui, Tadashi Ikeda, Ryuzo Sakata, Akira Shimatsu, Takeshi Kimura, Masatoshi FujitaKoji Hasegawa
  • Organizer: The 82th American Heart Association Annual Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 20091115-19
• [Presentation] Novel drug-delivery system of oral curcumin that prevents the deterioration of systolic function after myocardial infarction in rats (2009)
  • Author(s): Yoichi Sunagawa, Hiroyuki Fukuda, Hiromichi Wada, Tomohide Takaya, Akira Marui, Kazuhide Uemura, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: The 82th American Heart Association Annual Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 20091115-19
• [Presentation] Curcumin Prevents the Development of Hypertension-induced Left Ventricular Hypertrophy in Rats (2009)
  • Author(s): Yoichi Sunagawa, Tatsuya Morimoto, Teruhisa Kawamura, Tomohide Takaya, Hiromichi Wada, Kazuhide Uemura, Akira Shimatsu, Takeshi Kimura, Masatoshi FujitaKoji Hasegawa
  • Organizer: The 82th American Heart Association Annual Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 20091115-19
• [Presentation] Curcumin exerts synergistic effects with ACE inhibitor during LV systolic function restoration after rat myocardial infarction (2009)
  • Author(s): Yoichi Sunagawa, Tatsuya Morimoto, Tomohide Takaya, Masatoshi Fujita, Takeshi KimuraKoji Hasegawa
  • Organizer: The 5th China-Japan Cardiovascular Forum
  • Place of Presentation: Beijing, China
  • Year and Date: 20091011-12
• [Presentation] Cdk9 kinase activity is required for p300 phosphorylation and regulate transcriptional pathway during hypertrophic responses in cardiomyocytes (2009)
  • Author(s): Taishi Terada, Tatsuya Morimoto, Yoichi Sunagawa, Masatoshi Fujita, Takeshi KimuraKoji Hasegawa
  • Organizer: The 5th China-Japan Cardiovascular Forum
  • Place of Presentation: Beijing, China
  • Year and Date: 20091011-12
• [Presentation] A natural p300-specific histone acetyltransferase inhibitor, Curcumin, can prevent the development of heart failure in addition to ACE inhibitor after myocardial infarction in rats (2009)
  • Author(s): Tatsuya Morimoto, Masatoshi Fujita, Yoichi Sunagawa, Hiromichi Wada, Tomohide Takaya, Shigeki Yanagi, Akira Marui, Tadashi Ikeda, Akira ShimatsuKoji Hasegawa
  • Organizer: European Society of Cardiology Congress
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20090829-0902
• [Presentation] A Natural p300-specific HAT Inhibitor, Curcumin, Possesses Beneficial Effects in Addition to ACE Inhibitor after Rat Myocardial Infarction (2009)
  • Author(s): Tatsuya Morimoto, Yoichi Sunagawa, Hiromichi Wada, Tomohide Takaya, Shigeki Yanagi, Akihiro Sugimoto, Masaki Tsukashita, Akira Marui, Tadashi Ikeda, Masatoshi Fujita, Akira Shimatsu, Toru KitaKoji Hasegawa
  • Organizer: 17th Asian Pacific Congress of Cardiology
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20090520-23
• [Remarks]
  • URL: http://w3pharm.u-shizuoka-ken.ac.jp/～byoutai/