2011 Fiscal Year Final Research Report
Role of splicing variants in heart failure
| Project/Area Number |
21590945
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
ASAKURA Masanori 独立行政法人国立循環器病研究センター, 臨床研究部, 室長 (80443505)
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| Co-Investigator(Kenkyū-buntansha) |
KITAKAZE Masafumi 独立行政法人国立循環器病研究センター, 臨床研究部, 部長 (20294069)
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| Co-Investigator(Renkei-kenkyūsha) |
ASANUMA Hiroshi 京都府立医科大学, 大学院・医学研究科循環器内科学, 准教授 (20416217)
TAKASHIMA Seiji 大阪大学, 大学院・医学系研究科分子心血管医学, 特任准教授 (90379272)
MINAMINO Tetsuo 大阪大学, 大学院・医学系研究科循環器内科学, 講師 (30379234)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 循環器・高血圧 / マイクロアレイ / 遺伝子 / 心不全 / スプライシング |
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| Research Abstract |
Number of patients with chronic heart failure is increasing in Japan. It is important to detect novel targets for heart failure. Alternative splicing is known to play important roles in the regulations of several diseases such as cancer and neurodegenerative diseases. However, the role of alternative splicing in the pathogenesis of heart failure remains unclear. In this study, we analyzed global expression levels of splicing variants in heart failure using exon arrays. We identified 46 genes with significant changes in splicing pattern but without changes in expression level. Out of 46 candidate genes responsible for heart failure, we narrowed our focus to Mtus1 gene. Our functional analyses revealed that Mtus1A variant is a novel inhibitory factor for cardiac hypertrophy.
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[Journal Article] Identification of Genes related to Heart Failure Using Global Gene Expression Profiling of Human Failing Myocardium2010
Author(s)
Min KD, Asakura M, Liao Y, Nakamaru K, Okazaki H, Takahashi T, Fujimoto K, Ito S, Takahashi A, Asanuma H, Yamasaki S, Minamino T, Sanada S, Seguchi O, Nakano A, Ando Y, Otsuka T, Furukawa H, Isomura T, Takashima S, Mochizuki N, Kitakaze M
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Journal Title
Biochem Biophys Res Commun
Volume: 393(1)
Pages: 55-60
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