2011 Fiscal Year Final Research Report
Therapeutic angiogenesis using adipose-derived regenerative cells
| Project/Area Number |
21590951
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
SHINTANI Satoshi 名古屋大学, 大学院・医学系研究科, 講師 (20309777)
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| Co-Investigator(Kenkyū-buntansha) |
MUROHARA Toyoaki 名古屋大学, 大学院・医学系研究科, 教授 (90299503)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 血管新生療法 / 脂肪由来間葉系前駆細胞 / リンパ管新生 / マクロファージ |
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| Research Abstract |
It has been known that adipose-derived regenerative cells(ADRCs) secrete multiple angiogenic growth factors. We reported that ADRCs implantation improve severe ischemia and seems to be a useful strategy of therapeutic angiogenesis. Next, we focused on VEGF-C that ADRCs released. ADRCs therapy increased lymphatic capillary density and significantly reduced tissue edema. We consider that BM derived M2 macrophages plays an important role in postnatal lymphangiogenesis.
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