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2011 Fiscal Year Final Research Report

Therapeutic angiogenesis using adipose-derived regenerative cells

Research Project

  • PDF
Project/Area Number 21590951
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionNagoya University

Principal Investigator

SHINTANI Satoshi  名古屋大学, 大学院・医学系研究科, 講師 (20309777)

Co-Investigator(Kenkyū-buntansha) MUROHARA Toyoaki  名古屋大学, 大学院・医学系研究科, 教授 (90299503)
Project Period (FY) 2009 – 2011
Keywords血管新生療法 / 脂肪由来間葉系前駆細胞 / リンパ管新生 / マクロファージ
Research Abstract

It has been known that adipose-derived regenerative cells(ADRCs) secrete multiple angiogenic growth factors. We reported that ADRCs implantation improve severe ischemia and seems to be a useful strategy of therapeutic angiogenesis. Next, we focused on VEGF-C that ADRCs released. ADRCs therapy increased lymphatic capillary density and significantly reduced tissue edema. We consider that BM derived M2 macrophages plays an important role in postnatal lymphangiogenesis.

  • Research Products

    (20 results)

All 2012 2011 2010 2009

All Journal Article (8 results) (of which Peer Reviewed: 5 results) Presentation (7 results) Book (5 results)

  • [Journal Article] ヒト皮下脂肪組織由来間葉系前駆細胞を用いた重症虚血肢に対する血管新生療法の試み:特集:血管・心筋再生はどこまできたか[治す]PADに対する再生治療Heart Veiw2011

    • Author(s)
      新谷理
    • Journal Title

      CARDIAC PRACTICE

      Volume: Vol15 No.8 Pages: 90-96

  • [Journal Article] Impact of as ingle intracoronary administration of adiponectin on myocardial ischemia/reperfusion injury in a pigmodel2010

    • Author(s)
      Kondo K, Shibata R, Unno K, Shimano M, Ishii M, Kitoh T, Shintani S, Walsh K, Ouchi N, Murohara T.
    • Journal Title

      Circ Cardiovasc Interv

      Volume: 3(2) Pages: 166-173

    • Peer Reviewed
  • [Journal Article] 血管再生療法は重症虚血肢を救えるか:CARDIAC PRACTICE2010

    • Author(s)
      室原豊明, 新谷理, 小椋康弘, 清水優樹
    • Journal Title

      CARDIAC PRACTICE

      Volume: Vol.21No.2 Pages: 27-34

  • [Journal Article] Evidence for the the rapeuticpotential of ex vivo expanded humane do the lial progenitor cells using autologous serum2010

    • Author(s)
      Shumiya T, Shibata R, Shimizu Y, Ishii M, Kubota R, Shintani S, Murohara T.
    • Journal Title

      Circ J

      Volume: 74(5) Pages: 1006-1013

    • Peer Reviewed
  • [Journal Article] Kitagawa Y Murohara T Implantation of adipose-derived regenerative cells enhances ischemia-induces angiogenesis2009

    • Author(s)
      Kondo K, Shintani S, Shibata R, Murakami H, Murakami R, Imaizumi M.
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 29 Pages: 61-66

    • Peer Reviewed
  • [Journal Article] Autologous adipose-derived regenerative cells for the rapeutic angiogenesis2009

    • Author(s)
      Murohara T, Shintani S, Kondo K.
    • Journal Title

      Curr Pharm Des

      Volume: 15(24) Pages: 2784-2790

    • Peer Reviewed
  • [Journal Article] 細胞移植によるハイブリッド血管新生療法の開発2009

    • Author(s)
      新谷理
    • Journal Title

      日本冠疾患学会雑誌

      Volume: Vol.15 No.3 Pages: 193-197

    • Peer Reviewed
  • [Journal Article] 骨髄細胞を用いた血管新生療法:循環器科2009

    • Author(s)
      新谷理, 室原豊明
    • Journal Title

      科学評論社

      Volume: Vol.66 No4 Pages: 353-358

  • [Presentation] M2 macro phages contribute to postnatal lymph angiogenesis as lymphatic endothelial progenitors2011

    • Author(s)
      Shimizu Y, Shintani S, Shibata R, Izumi Y, Ogura Y, Ishii M, Murohara T.
    • Organizer
      2011 American Heart Association
    • Place of Presentation
      Orland
    • Year and Date
      2011-11-14
  • [Presentation] Im plantation of adipose-derived regenerative cells enhances lymph angiogenesis and improves secondary lymph edema2011

    • Author(s)
      Shimizu Y, Shintani S, Shibata R, Izumi Y, Ogura Y, Ishii M, Murohara T.
    • Organizer
      2011 American Heart Association
    • Place of Presentation
      Orland
    • Year and Date
      2011-11-14
  • [Presentation] The rape tic lymph angiogenesis with implantation of adipose-derived regenerative cells2011

    • Author(s)
      Shimizu Y, Shintani S, Shibata R, Izumi Y, Ogura Y, Ishii M, Murohara T.
    • Organizer
      2011 European Society of Cardiology
    • Place of Presentation
      Paris
    • Year and Date
      2011-08-30
  • [Presentation] 皮下脂肪組織由来間葉系前駆細胞移植による血管新生療法.新たな細胞供給源を求めて2011

    • Author(s)
      新谷理、室原豊明
    • Organizer
      第27回日本医工学治療学会学術大会
    • Place of Presentation
      岡山
    • Year and Date
      2011-04-24
  • [Presentation] Implantation of Adipose-Derived Regenerative Cells Enhances Is chemia-induced Neovascularization. Role of SDF-1-mediated Endothelial Progenitor Cell Mobilization2009

    • Author(s)
      Shintani S, Kondo K, Kitagawa Y, Murohara T
    • Organizer
      7^<th> International Federation of Adipose Therapeutics & Science(IFATS)
    • Place of Presentation
      Daegu Korea
    • Year and Date
      2009-10-16
  • [Presentation] 細胞移植による血管新生療法.新たな細胞供給源を求めて2009

    • Author(s)
      新谷理、近藤和久、室原豊明
    • Organizer
      第30回日本動脈アフェレシス学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2009-09-12
  • [Presentation] 脂肪組織由来間葉系前駆細胞移植による血管再生療法2009

    • Author(s)
      新谷理、近藤和久、室原豊明
    • Organizer
      第41回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      下関
    • Year and Date
      2009-07-17
  • [Book] 血管内皮前駆細胞とVEGF「血管再生治療」浅原孝之編2012

    • Author(s)
      新谷理
    • Total Pages
      93-96
    • Publisher
      診断と治療社
  • [Book] EarlyEPCとlate EPCとは「循環器再生医学の現状と展望」室原豊明編2011

    • Author(s)
      新谷理、泉雄介、室原豊明
    • Total Pages
      201-205
    • Publisher
      メディカルレビュー社
  • [Book] 自己骨髄単核球細胞移植による血管新生療法の開発「循環器再生医学の現状と展望」室原豊明編2011

    • Author(s)
      新谷理、室原豊明
    • Total Pages
      63-69
    • Publisher
      メディカルレビュー社
  • [Book] 重症ASOに対する血管新生療法の開発「閉塞性動脈硬化症診療マスターブック」朔啓二郎編2010

    • Author(s)
      新谷理、近藤和久、小椋康弘、清水優樹、室原豊明
    • Total Pages
      140-148
    • Publisher
      新興医学出版社
  • [Book] 閉塞性動脈硬化症「薬学生のための新臨床医学.症候および疾患とその治療」市田公美、細山田真編2009

    • Author(s)
      嶋野祐之、新谷理、室原豊明
    • Total Pages
      138-142
    • Publisher
      廣川書店

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Published: 2013-07-31  

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