2011 Fiscal Year Final Research Report
Therapeutic angiogenesis using adipose-derived regenerative cells
| Project/Area Number |
21590951
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
SHINTANI Satoshi 名古屋大学, 大学院・医学系研究科, 講師 (20309777)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MUROHARA Toyoaki 名古屋大学, 大学院・医学系研究科, 教授 (90299503)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 血管新生療法 / 脂肪由来間葉系前駆細胞 / リンパ管新生 / マクロファージ |
|---|
| Research Abstract |
It has been known that adipose-derived regenerative cells(ADRCs) secrete multiple angiogenic growth factors. We reported that ADRCs implantation improve severe ischemia and seems to be a useful strategy of therapeutic angiogenesis. Next, we focused on VEGF-C that ADRCs released. ADRCs therapy increased lymphatic capillary density and significantly reduced tissue edema. We consider that BM derived M2 macrophages plays an important role in postnatal lymphangiogenesis.
|
Research Products
(20 results)
