2011 Fiscal Year Final Research Report
The Molecular Mechanism Underlying Atherosclerotic Plaque Rupture : Impact on Cysteinyl Cathepsin and Vascular Smooth Muscle Cell Apoptosis
| Project/Area Number |
21590952
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
CHENG Xianwu 名古屋大学, 大学院・医学系研究科, 特任講師 (30378228)
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| Co-Investigator(Renkei-kenkyūsha) |
KUZUYA Masahumi 名古屋大学, 大学院・医学系研究科, 教授
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| Project Period (FY) |
2009 – 2011
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| Keywords | プラーク破綻 / カテプシン / スタチン |
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| Research Abstract |
Although recent studies have suggested that cysteinyl cathepsins(Cats) participate in cell apoptosis, the Cat-related precise mechanism of in atherosclerotic plaque disruption remains poorly understood. Here, we focused to investigate the role of Cat in plaque rupture using a mouse carotid artery plaque rupture model. We have observed that CatS involves vascular smooth muscle cell apoptosis and contributes to plaque rupture. CatS is an important determination of atherosclerotic plaque composition and disruption, rendering CatS an attractive target for pharmaceutical prevention in atherosclerotic plaque vulnerability.
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