New Mechanisms of the Protection against the Increase in Oxidative Stress in Hypertension

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590954
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Yamaguchi University
• Principal Investigator: UMEMOTO Seiji 山口大学, 医学部附属病院, 准教授 (90263772)
• Co-Investigator(Kenkyū-buntansha): YOSHIMURA Kohichi 山口大学, 大学院・医学系研究科, 准教授 (00322248)
• Project Period (FY): 2009 – 2011
• Keywords: Oxidative stress / Toll-like receptor / Angiotensin II / Superoxide dismutase

Research Abstract

Angiotensin II(AngII) increased oxidative stress and induced vascular remodeling through AngII type 1 receptor via TLR4, whereas TLR4 directly inhibited ecSOD to promote the production of oxidative stress and vascular remodeling. PPARγwas not involved in these processes.

Research Products

• [Journal Article] Nifedipine activates PPARgamma and exerts antioxidative action through Cu/ ZnSOD independent of blood-pressure lowering in SHRSP (2010)
  • Author(s): Hashimoto R, Umemoto S, Guo F, Umeji K, Itoh S, Kishi H, Kobayashi S, Matsuzaki M
  • Journal Title: J Atheroscler Thromb. 2010 Aug 31 Volume: 17(8) Pages: 785-95
  • Peer Reviewed
• [Presentation] Toll-like receptorsignal adaptor protein MyD88 regulatesNAD(P) H oxidase-generated oxidative stress and vascular remodeling in angiotensin II-induced hypertension (2011)
  • Author(s): Nakashima T, Umemoto S, Matsuda S, Okamoto T, Murata T, Yoshimura K, FukaiT, Matsuzaki M
  • Organizer: ESC Congress 2011
  • Place of Presentation: Paris, France
  • Year and Date: 20110827-31
• [Presentation] Toll-like receptor 4 selectively activates MCP-1to induce cardiac hypertrophy and dysfunction in angiotensin II-inducedhypertension (2010)
  • Author(s): Matsuda S, Umemoto S, Yoshino H, Nakashima T, Ito S, Aoki H, YoshimuraK, Murata T, Matsuzaki M
  • Organizer: ESC Congress 2010
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 20100829-0902
• [Presentation] Toll-like receptor 4 increases oxidative stress by inhibiting the upregulation of extracellular superoxide dismutase in angiotensin II-induced hypertension (2009)
  • Author(s): Yoshino H, Umemoto S, Matsuda S, Nakashima T, Itoh S, Aoki H, YoshimuraK, Murata T, Fukai T, Matsuzaki M
  • Organizer: ESC Congress2009
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20090829-0902
• [Presentation] Angiotensin II induces cardiac systolic and diastolic dysfunction via Toll-like receptor 4 mediated upregulation of oxidative stress in murine heart (2009)
  • Author(s): Matsuda S, Umemoto S, Yoshino H, AokiH, Itoh S, Yoshimura K, Murata T, Matsuzaki M
  • Organizer: The American Society of Hypertension, Inc 24^<rd> Annual Scientific Meeting and Exposition
  • Place of Presentation: San Francisco, USA
  • Year and Date: 20090506-09
• [Presentation] Toll-like receptor 4 augments angiotensin II-inducedoxidative stress by inhibiting the upregulation of extracellular superoxide dismutase (2009)
  • Author(s): Yoshino H, Umemoto S, Matsuda S, ItohS, Aoki H, Yoshimura K, Murata T, FukaiT, Matsuzaki M
  • Organizer: The American Society of Hypertension, Inc 24^<rd> Annual Scientific Meeting and Exposition
  • Place of Presentation: San Francisco, USA
  • Year and Date: 20090506-09
• [Remarks]
  • URL: http://ds.cc.yamaguchi-u.ac.jp/.ninai/