2011 Fiscal Year Final Research Report
Mechanisms of abnormal iron metabolism in metabolic syndrome and its implications for new therapeutic strategies
| Project/Area Number |
21590959
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MASUYAMA Tohru 兵庫医科大学, 医学部, 教授 (70273670)
KAWABATA Masaaki 兵庫医科大学, 医学部, 非常勤講師 (70411999)
NAITO Yoshiro 兵庫医科大学, 医学部, 講師 (10446049)
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| Project Period (FY) |
2009 – 2011
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| Keywords | メタボリックシンドローム / 鉄代謝 / 多血症 / インスリン抵抗性 / 高血圧 |
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| Research Abstract |
High body iron levels are found in type 2 diabetes mellitus(DM). Iron excess leads to tissue injury through free radical formation. We investigated the effect of iron restriction on diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty(OLETF) rats, a model of type 2 DM. In OLETF given high salt-high fat diet, iron restriction reduced systolic blood pressure, urinary excretion of protein and renal glomerular injury. Iron restriction suppressed oxidative stress and renin-angiotensin system in the kidney and attenuated renal hypoxia in the HFS+IR group compared to the HFS group. Iron restriction may be beneficial in prevention of nephropathy in type 2 DM.
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