2012 Fiscal Year Final Research Report
Development of therapeutic modality for fungus associated asthmaby dendritic cell vaccine
| Project/Area Number |
21590968
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nagasaki University |
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Principal Investigator |
MATSUSE Hiroto 長崎大学, 医歯薬学総合研究科, 准教授 (60336154)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUSHIMA Chizu 長崎大学, 病院, 准教授 (50380978)
KOHNO Shigeru 長崎大学, 医歯薬学総合研究科, 教授 (80136647)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 気管支喘息 / 真菌 / アレルギー / 樹状細胞 |
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| Research Abstract |
Aspergillus fumigatus potentially exacerbates eosinophilic allergic airway inflammation by adding neutrophilic inflammation and airway hypersecretion. Corticosteroids are effective for eosinophilic inflammation, while they can rarely inhibit neutrophilic inflammation and airway hypersecretion. Plasmacytoid dendritic cells can inhibit allergic airway inflammation through the induction of immuneregulatory IL10. Thus they could be a new therapeutic modality for treating fungus associated severe asthma.
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