2011 Fiscal Year Final Research Report

Mechanisms of the increased maternal transmission of neonatal asthma risks by exposure to air-pollution.

Research Project

Project/Area Number	21590969
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Respiratory organ internal medicine
Research Institution	Nara Medical University
Principal Investigator	HAMADA Kaoru 奈良県立医科大学, 医学部, 教授 (80228535)
Co-Investigator(Kenkyū-buntansha)	KIMURA Hiroshi 奈良県立医科大学, 医学部, 教授 (20195374) SHO Masayuki 奈良県立医科大学, 医学部, 准教授 (50364063) SUZAKI Yasue 奈良県立医科大学, 医学部, 助教 (30382302)
Project Period (FY)	2009 – 2011
Keywords	気管支喘息 / 大気汚染 / 喫煙Th2サイトカイン / エピジェネティクス
Research Abstract	Increased incidence of asthma and other allergic diseases are the worldwide problem. Air-pollution is recognized as one of the important factor for pathogenesis of asthma. We have investigated whether exposure to air-pollution such as oil fly as, formaldehyde and tobacco smoking during pregnancy can contribute to development of asthma in the offspring. Data indicated neonatal mice from mothers exposed to pollutants before delivery could express asthma manifestation by the suboptimal sensitization. As the mechanism(s), these mice showed the persistent Th2-dominant immune profile after birth. Contribution of epigenetics to this maternal transmission or transplacental effect of asthma susceptibility should be clarified.