2011 Fiscal Year Final Research Report
Involvement of insulin resistance-associated ganglioside GM3 in the pathogenesis of bronchial asthma.
| Project/Area Number |
21590970
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHNO Isao 東北薬科大学, 薬学部, 教授 (00250762)
INOKUCHI Jinichi 東北薬科大学, 薬学部, 教授 (70131810)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 気管支喘息 / 肥満 / インスリン抵抗性 / ガングリオシド(GM3) |
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| Research Abstract |
To investigate the involvement of obesity and insulin resistance in the pathogenesis of bronchial asthma, we developed a murine allergic asthma model with high-fat diet-induced obesity. In wild type mice, high-fat diet-induced obesity increased airways inflammation after antigen inhalation. In contrast, the obesity did not increase the airways inflammation in the ganglioside GM3-defficient mice, which do not exhibit the feature of insulin resistance. These results demonstrate the involvement of obesity and insulin resistance in the pathogenesis of asthma.
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