2011 Fiscal Year Final Research Report
The effect of comorbidity, systemic inflammation and oxidative stress on the prognosis in COPD patients.
| Project/Area Number |
21590972
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUWANO Kazuyoshi 東京慈恵会医科大学, 医学部, 教授 (40205266)
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| Research Collaborator |
YUMINO Yoko 東京慈恵会医科大学, 医学部, 大学院生
NOJIRI Satoko 東京慈恵会医科大学, 医学部, 大学院生
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| Project Period (FY) |
2009 – 2011
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| Keywords | 慢性閉塞性肺疾患 / 全身性炎症 / 酸化ストレス / 基礎疾患 |
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| Research Abstract |
To evaluate the effects of comorbidities(CVD and DM) with COPD, systemic inflammation, or oxidative stress on the prognosis in COPD patients, 117 patients, over 40 years old with more than 10 pack-year were recruited. As the resilts, the frequency of COPD in patients with CVD or DM was approximately 40.0%, higher than that(16.5%) based on the NICE study. Systemic inflammation evaluated by hs-CRP or TNF-αwas reduced by statin usage. Oxidative stress evaluated by 8-OHdG increased in patients with COPD. According to the 2 year observation, the risk of common cold and the risk of hospitalization increased significantly in patients with COPD and CVD, respectively. In the analysis of COPD patients, COPD exacerbations could be reduced by statin usage, and rapid decline of pulmonary function could be reduced by tiotropium usage. The present study suggested that statin usage could improve the inflammation and QOL in the COPD patients. Comorbidity(CVD, DM, or both CVD & DM) was not associated with risk of COPD exacerbation or rapid decline of pulmonary function.
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[Presentation] The evaluation of systemic inflammation in COPD patients comorbided with cardiovascular diseases or diabetes mellitus2011
Author(s)
Yumino Y, Fujii S, Takasaka N, Kojima J, Hara H, Numata T, Ishikawa T, Kawaishi M, Saito K, Araya J, Nakayama K, Kuwano K
Organizer
European Respiratory Society Annual Congress 2011 Amsterdam
Place of Presentation
Netherland
Year and Date
20110925-28
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[Presentation] Insufficient autophagy is involved in accelerated cellular senescence in the pathophysiology of COPD2011
Author(s)
Fujii S, Hara H, Araya J, Takasaka N, Yumino Y, Kojima J, Ishikawa T, Numata T, Kawaishi M, Hirano J, Odaka M, Morikawa T, Nakayama K, Kuwano K
Organizer
European Respiratory Society Annual Congress 2011 Amsterdam
Place of Presentation
Netherland
Year and Date
20110925-28
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[Presentation] An inhibitor of HMG-CoA reductase, pitavastatin, inhibits rhinovirus infection in human tracheal epithelial cells2009
Author(s)
Nakayama K, Sasaki T, Yumino Y, Minagawa S, Nojiri S, Yoshida M, Numata T, Hara H, Kawaishi M, Araya J, Yamaya M, Kuwano K
Organizer
European Respiratory Society 2009 Annual Congress
Place of Presentation
Vienna
Year and Date
20090913-16
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[Book] Review-Nitric oxide and cancer : prognosis, prevention and therapy-VI. Therapeutic applications of nitric oxide for malignant tumor in animal models and human studies. Nitric Oxide(NO) and Cancer : Prognosis, Prevention, and Therapy2010
Author(s)
Yasuda H, Yanagihara K, Nakayama K, MioT, Sasaki T, Asada M, Yamaya M, and Fukushima M
Total Pages
400
Publisher
Springer
