2011 Fiscal Year Final Research Report
Research of the pathoetiology of chronic obstructive pulmonary disease
| Project/Area Number |
21590973
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YAGI Osamitsu 東京女子医科大学, 医学部, 助教 (30439806)
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| Project Period (FY) |
2009 – 2011
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| Keywords | COPD / 炎症 / アポトーシス / 細胞老化 / DNA障害 / クララ細胞 / 肺胞上皮細胞 |
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| Research Abstract |
This study was aimed to elucidate the pathoetiologic mechanisms of chronic obstructive pulmonary disease(COPD). We found that 1) chronic inflammation, apoptosis, cell senescence, and DNA damage occur in the lungs of COPD patients ; 2) DNA damage to airway epithelial cells in mice caused cell senescence and chronic airway inflammation ; and 3) DNA-damaged airway and alveolar epithelial cells produced a large amount of proinflammatory cytokines. These findings suggest that DNA damage plays an important role in inflammation, apoptosis, cell senescence in the lungs of COPD patients.
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