2011 Fiscal Year Final Research Report
Indentification of regulatory factors for airway epithelial barrier and study for the role on airway inflammtion
| Project/Area Number |
21590975
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nihon University |
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Principal Investigator |
GON Yasuhiro 日本大学, 医学部, 准教授 (80339316)
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| Co-Investigator(Kenkyū-buntansha) |
RA Chisei 日本大学, 医学部, 教授 (60230851)
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| Co-Investigator(Renkei-kenkyūsha) |
HAYASHI Shinichi 日本大学, 医学部, 助教 (20445745)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 気道上皮 / 気管支喘息 / タイトジャンクション / 気道炎症 / 気道上皮細胞 |
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| Research Abstract |
The airway epithelial barrier provides defenses against inhaled antigens and pathogens, and alterations of epithelial barrier function have been proposed to play a significant role in the pathogenesis of chronic airway diseases. In this study, we demonstrated that EGFR positively regulates permeability barrier development through the Rac1/JNK-dependent pathway. We also found that heregulin activation of ErbB2/ErbB3 heterodimers is essential for the regulation of permeability barrier in the airway epithelial cells. We also found that glucocorticoids have an effects of improving epithelial barrier integrity.
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