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2011 Fiscal Year Final Research Report

Establishment of a simple differentiation diagnostic method of glucoprotein tumor markers by the pattern analysis in Western blotting

Research Project

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Project/Area Number 21590981
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionUniversity of Tsukuba

Principal Investigator

SATOH Hiroaki  筑波大学, 医学医療系, 教授 (00261800)

Co-Investigator(Kenkyū-buntansha) OHTSUKA Morio  筑波大学, 医学医療系, 教授 (00143173)
Project Period (FY) 2009 – 2011
Keywords癌 / 肺癌 / 腫瘍マーカー / 診断法 / 泳動パターン
Research Abstract

It is not clear whether structures of glucoprotein tumor markers such carcinoembryonic antigen (CEA) and CA19-9 differ or not in various cancers. Western blot analysis of the expression patterns in various cancers was performed using original antibody against CEA which we made. The expression pattern of them was ladder bands pattern. In serum from lung, bands larger than 150kD were observed, but they were not in serum form other cancer patients and normal control (p=0.0352). Expression patterns were evaluated in such analysis using antibody against CA19-9 in sera from pancreas and colon cancers. A clue of simple differentiation diagnostic method of glucoprotein tumor markers by the pattern analysis in Western blotting was established.

  • Research Products

    (1 results)

All 2011

All Presentation (1 results)

  • [Presentation] 泳動パターン解析による糖蛋白腫瘍マーカーの簡便な鑑別診断法の確立2011

    • Author(s)
      佐藤浩昭, 他
    • Organizer
      第52回日本肺癌学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2011-11-03

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Published: 2013-07-31  

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