2011 Fiscal Year Final Research Report
Novel dendritic cell vaccine for tuberculosis with inhibition of indoleamine 2, 3-dioxygenase.
| Project/Area Number |
21590985
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
SUDA Takafumi 浜松医科大学, 医学部, 助教 (30291397)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Yutaro 浜松医科大学, 医学部附属病院, 助教 (60436962)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGATA Toshi 浜松医科大学, 医学部, 教授 (90275024)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 樹状細胞 / ワクチン / 結核 / 細胞内寄生菌 / indoleamine 2 / 3-dioxygenase(IDO) |
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| Research Abstract |
The present study was conducted to develop a novel potent dendritic cell(DC) vaccine by inhibiting indoleamine 2, 3-dioxygenase(IDO) activity for intracellular pathogen infections, such as tuberculosis. We demonstrated that treatment with 1-methyl-L-tryptophan(1MT) decreased IL-10 production from DCs, resulting in augmentation of their antigen-presenting capacity. In addition, we also showed that serum IDO activity is a significant prognostic factor in community-acquired pneumonia and pulmonary tuberculosis.
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[Journal Article] Mouse CD11b^<high> lung dendritic cells have more potent capability to induce IgA than CD103^+lung dendritic cells in vitro2012
Author(s)
Suzuki Y, Suda T, Furuhashi K, Shibata K, Hashimoto D, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Nakamura H, Chida K
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Journal Title
Am J Respir Cell Mol Biol
Volume: (in press)
Peer Reviewed
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