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2011 Fiscal Year Final Research Report

The establishment of therapeutic strategy for pulmonary fibrosis and pulmonary hypertension in targeting endothelial-mesenchymal transition

Research Project

  • PDF
Project/Area Number 21590987
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionNagoya University

Principal Investigator

HASHIIMO Naozumi  名古屋大学, 医学部附属病院, 助教 (30378020)

Co-Investigator(Kenkyū-buntansha) HASEGAWA Yoshinori  名古屋大学, 大学院・医学系研究科, 教授 (20270986)
IMAIZUMI Kazuyoshi  藤田保健衛生大学, 大学院・医学研究科, 教授 (50362257)
Project Period (FY) 2009 – 2011
Keywords呼吸器病学
Research Abstract

Current evidence suggests that the pathogenesis of pulmonary fibrosis might be due to the heterogeneity of fibroblast origins. In this study, persistent tissue hypoxia might be involved in active fibrosis in an in vivo model of BLM-induced lung injury/fibrosis, likely due to endothelial-mesenchymal transition. These findings indicate that persistent tissue hypoxia as tissue microenvironment may promote secondary EMT and lung fibrosis. These also indicate the clue to understand the underlying mechanism of lung fibrosis, leading the new therapeutic strategy.

  • Research Products

    (10 results)

All 2012 2011

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (4 results)

  • [Journal Article] Quercetin protects against pulmonary oxidant stress via heme oxygenase-1 induction in lung epithelial cells2012

    • Author(s)
      Hayashi Y, Matsushima M, Nakamura T, Shibasaki M, Hashimoto N, Imaizumi K, Shimokata K, Hasegawa Y, KawabeT.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 417(1) Pages: 169-174

    • Peer Reviewed
  • [Journal Article] Acute exacerbation of IPF following diagnostic broncho alveolar lavage procedures2012

    • Author(s)
      Sakamoto K, Taniguchi H, Kondoh Y, Wakai K, Kimura T, Kataoka K, Hashimoto N, Nishiyama O, Hasegawa Y.
    • Journal Title

      Respir Med

      Pages: 436-42

    • Peer Reviewed
  • [Journal Article] Mesenchymal Stem Cells Stably Transduced with a Dominant CCL2 Greatly Attenuate Bleomycin-Induced Mesenchymal Stem Cells Stably Transduced with a Dominant-Negative Inhibitor ofCCL2 Greatly Attenuate Bleomycin-Induced Lung Damage2011

    • Author(s)
      Saito S, Nakayama T, Hashimoto N, Miyata Y, Egashira K, Nakao N, Nishiwaki S, Hasegawa M, Hasegawa Y, Naoe T.
    • Journal Title

      Am J Pathol

      Volume: 179(3) Pages: 1088-94

    • Peer Reviewed
  • [Journal Article] Involvement of the transcription factor twist in phenotype alteration throughe pithelial-mesenchymal transition in lung cancercells2011

    • Author(s)
      Nakashima H, Hashimoto N, Aoyama D, Kohnoh T, Sakamoto K, Kusunose M, Imaizumi K, Takeyama Y, Sato M, Kawabe T, Hasegawa Y.
    • Journal Title

      Mol Carcinog

    • DOI

      DOI:10.1002/mc.20802

    • Peer Reviewed
  • [Journal Article] Capsaicinoids regulate airway anion transporters through Rho kinaseandc AMP-dependent mechanisms2011

    • Author(s)
      Hibino Y, Morise M, Ito Y, Mizutani T, Matsuno T, Ito S, Hashimoto N, Sato M, Kondo M, Imaizumi K, and Hasegawa Y
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 45(4) Pages: 684-91

    • Peer Reviewed
  • [Journal Article] Attenuation of TGF-ss-Stimulated Collagen Production in Fibroblasts by Quercetin-InducedHO-1.2011

    • Author(s)
      Nakamura T, Matsushima M, Hayashi Y, Shibasaki M, Imaizumi K, Hashimoto N, Shimokata K, Hasegawa Y, Kawabe T.
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 44(5) Pages: 614-20

    • Peer Reviewed
  • [Presentation] Inhibition of TGFbeta induced epithelial mesenchymal transition in lung cancer by modulation of PTEN c-terminal tail2011

    • Author(s)
      Naozumi Hashimoto
    • Organizer
      日本癌学会総会
    • Place of Presentation
      日本,名古屋
    • Year and Date
      2011-10-04
  • [Presentation] Inspiratory capacity is a new preoperative risk predictor in the patients with lung cancer undergoing surgical resection European Respiratory Society Congress2011

    • Author(s)
      Naozumi Hashimoto
    • Organizer
      オランダ、アムステルダム
    • Place of Presentation
      アムステルダム
    • Year and Date
      2011-09-27
  • [Presentation] Inhibition of Hypoxia-induced phenotype alterations through epithelial-mesenchymal transition(EMT) in lung cancer by gene modulation of phosphorylation sites in tumor suppressor PTEN European Respiratory Society Congress2011

    • Author(s)
      Naozumi Hashimoto
    • Organizer
      オランダ、アムステルダム
    • Place of Presentation
      アムステルダム
    • Year and Date
      2011-09-27
  • [Presentation] A critical involvement of chronic obstructive pulmonary disease as a preo perative risk factor in the patients with lung cancer undergoing surgical resection2011

    • Author(s)
      Naozumi Hashimoto
    • Organizer
      American Thoracic Society 2011
    • Place of Presentation
      アメリカ、デンバー
    • Year and Date
      2011-05-17

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Published: 2013-07-31  

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